Mepolizumab and Muscle Spasms: What Users Say

• Nic...
• August 6, 2019

Mepolizumab for Asthma "I have been on Nucala for 2 years. I am 41 years old. I’ve had several sinus infections, coughing like crazy, reflux. When the Dr. discovered I had Eosinophilic allergic asthma, he put me on Nucala. About 10 minutes after my injection, I had severe back pain & fatigue. As time goes by, I’m noticing more side effects. I’ve lost 30% of my hair. Severe dry skin on face. Arthritic pain. Headaches. Nucala has helped me tremendously, but I’m so upset about all my thinning/lost hair. I’ve had every blood test done. Thyroid checked. All good. Has to be a side effect. Everyone, PLEASE REPORT ALL YOUR SIDE EFFECTS!!! They need to know so many people are suffering from hair loss, joint pain, fatigue, headaches, muscle spasms, etc. I have to meet with my Dr. again to go over all this."

• Alw...
• Taken for 1 to 2 years
• January 24, 2020

Mepolizumab for Asthma "After two years on Nucala, I have had enough. For the past three months, I have had excruciating joint pain in my knees, ankles, wrists, elbows, and fingers to the point that I cannot run at all or even walk without pain. While on Nucala, my joints have always been hurting, but now it's just so much worse. I've also suffered from headaches, sore throat, muscle spasms, chest and back pain, and some eczema. I lost half of my hair in the last two months and some of my eyebrows as well. The weird thing is, all was well for over a year and a half, except for some minor joint ache, but then suddenly everything went bad really fast. Now I have to wait for a few months for Nucala to leave my system, and hopefully things will return to normal. It did help with my asthma and nasal polyps, but now the side effects are just too much."

• wre...
• June 21, 2021

Mepolizumab for Asthma "I feel like I have been poisoned! It only works for about three weeks, but I still have asthma symptoms. My hair is falling out like I am on chemo, and I have terrible muscle spasms that paralyze my legs. I am stopping this awful medicine. The benefits do not override the risks. I'm done!!!"

• suy...
• Taken for 1 to 6 months
• September 8, 2019

Mepolizumab for Asthma "I had my first Nucala shot in June 2019, and it seems to help my asthma. I completely stopped taking prednisone, which was amazing because I have become totally dependent on it to breathe. My second Nucala shot, I started to notice several side effects: severe back pain, stomach pain, urinary tract infection, and the final straw was severe muscle pain and spasms. The pain I experience from the muscle spasms is so bad I cry. I had to discontinue this drug. I was very hopeful this would be the answer to my asthma, so now I am back on prednisone."

• Mar...
• Taken for 1 to 6 months
• February 6, 2022

Mepolizumab for Asthma "I wanted to thank everyone for taking the time to write their experiences. In particular, one person wrote about the different asthma medications with the same effects. My asthma has been under control while on Xolair, Dupixent, forget Fasenra, and now Nucala. I’ve had muscle and joint pain with all of them, but this is my third month on Nucala, and the muscle and joint pains are worse. I’m having a real hard time with my thumbs, severe pain even when I’m not using my hands. I’ve developed a bone spur on my left thumb that is extremely painful to the touch. I’m not sure if I now have arthritis. I’m so confused about what to do next. I guess I’ll stay on Nucala until it’s obvious beyond any doubt that it is the cause of it all, and I’m unable to manage the pain. Back, neck, spine, hands, muscle spasm on my calves, etc. I forgot to mention my eosinophils were so high I was hospitalized, another reason why I was switched over to Nucala. I hope some will benefit!"

• Lil...
• July 2, 2021

Mepolizumab for Asthma "I will definitely start reporting again as the symptoms are similar to others. It’s definitely making my asthma better, but I have side effects of lower back pain, earaches, and muscle spasms, which are real with this injection. Please report your side effects, guys, the better data they gather from the community, the better for the next person."

• Anonymous
• Taken for 1 to 6 months
• February 27, 2020

Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis "I have been getting the Nucala injections for about 6 months now, and for the first couple of months, I could breathe okay but developed a sinus/ear infection that caused a complete blockage in my ear. I have still been having to use my nebulizer treatments and rescue inhaler and have severe fatigue, headaches, muscle spasms, and back pain. I will not be getting any more of these injections."

• Bha...
• Taken for less than 1 month
• October 20, 2021

For Hypereosinophilic Syndrome "My 17-year-old got her 3 shots today. We don't know how soon we will see results, but she has back spasms and injection site pain. Anyone know how long it takes for the back pain to go?"