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Mepolizumab use while Breastfeeding

Drugs containing Mepolizumab: Nucala

Medically reviewed by Drugs.com. Last updated on Sep 21, 2020.

Mepolizumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of mepolizumab during breastfeeding. Because mepolizumab is a large protein molecule with a molecular weight of 149,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. A task force respiratory experts from Europe, Australia and New Zealand found that mepolizumab is possibly acceptable during breastfeeding.[1] Until more data become available, mepolizumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Asthma) Benralizumab, Omalizumab

References

1.
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020;55:1901208. [PubMed: 31699837]

Substance Identification

Substance Name

Mepolizumab

CAS Registry Number

196078-29-2

Drug Class

Breast Feeding

Lactation

Anti-Allergic Agents

Anti-Asthmatic Agents

Antibodies, Monoclonal, Humanized

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Further information

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