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Benralizumab use while Breastfeeding

Drugs containing Benralizumab: Fasenra

Medically reviewed by Drugs.com. Last updated on Sep 30, 2020.

Benralizumab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of benralizumab during breastfeeding. Because benralizumab is a large protein molecule with a molecular weight of about 150,000 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. A task force respiratory experts from Europe, Australia and New Zealand found that benralizumab is possibly safe during breastfeeding.[1] Until more data become available, benralizumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Benralizumab is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[2,3] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[4] None of the studies measured IgG activity.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Asthma) Omalizumab, Mepolizumab

References

1.
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020;55:1901208. [PubMed: 31699837]
2.
Koenig A, de Albuquerque Diniz EM, Barbosa SF, et al. Immunologic factors in human milk: The effects of gestational age and pasteurization. J Hum Lact. 2005;21:439–43. [PubMed: 16280560]
3.
Adhisivam B, Vishnu Bhat B, Rao K, et al. Effect of Holder pasteurization on macronutrients and immunoglobulin profile of pooled donor human milk. J Matern Fetal Neonatal Med. 2019;32:3016–9. [PubMed: 29587541]
4.
Rodríguez-Camejo C, Puyol A, Fazio L, et al. Antibody profile of colostrum and the effect of processing in human milk banks: Implications in immunoregulatory properties. J Hum Lact. 2018;34:137–47. [PubMed: 28586632]

Substance Identification

Substance Name

Benralizumab

CAS Registry Number

1044511-01-4

Drug Class

Breast Feeding

Lactation

Anti-Allergic Agents

Anti-Asthmatic Agents

Antibodies, Monoclonal, Humanized

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Further information

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