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Xhance Nasal Spray

Generic name: fluticasone nasalfloo-TIK-a-sone ]
Drug class: Nasal steroids

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 23, 2023.

What is Xhance?

Xhance is a nasal spray containing fluticasone propionate. Fluticasone propionate is a corticosteroid that prevents the release of substances in the body that cause inflammation.

Xhance nasal spray is a prescription medicine used to treat nasal polyps in adults.

It is not known if Xhance is safe and effective in children.


Before using Xhance Nasal Spray, tell your doctor if you have glaucoma or cataracts, liver disease, diabetes, herpes simplex virus of your eyes, tuberculosis or any other infection, sores or ulcers inside your nose, or if you have recently had injury of or surgery on your nose.

Fluticasone can lower blood cells that help your body fight infections. Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using Xhance nasal spray.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Do not use Xhance Nasal Spray in a person younger than 18 years old.

Before taking this medicine

You should not use Xhance if you are allergic to fluticasone.

Fluticasone can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

To make sure Xhance is safe for you, tell your doctor if you have ever had:

  • sores or ulcers inside your nose;

  • injury of or surgery on your nose;

  • glaucoma or cataracts;

  • liver disease;

  • diabetes;

  • a weak immune system; or

  • any type of infection (bacterial, fungal, viral, or parasitic).

Tell your doctor if you are pregnant or breast-feeding.

How should I use Xhance?

Use Xhance exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not share this medicine with another person, even if they have the same symptoms you have.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Shake the nasal spray just before each use.

If you switched to fluticasone from another steroid medicine, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.

It may take several days before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after a week of treatment.

Store Xhance in an upright position at room temperature, away from moisture and heat. Throw the spray bottle away after you have used 120 sprays, even if there is still medicine left in the bottle.

Dosing information

Usual Adult Dose for Nasal Polyps: The recommended dosage of Xhance nasal spray is 1 spray (93 mcg of fluticasone propionate per spray) in each nostril twice daily (total daily dose, 372 mcg).

A dose of 2 sprays (93mcg of fluticasone propionate per spray) in each nostril twice daily may also be effective in some patients (total daily dose, 744 mcg).

The maximum total daily dosage should not exceed 2 sprays in each nostril twice daily (total daily dose, 744 mcg).

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of fluticasone is not expected to produce life threatening symptoms. Long term use of steroid medicine can lead to glaucoma, cataracts, thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using Xhance nasal spray?

Avoid getting the spray in your eyes or mouth. If this does happen, rinse with water.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Xhance.

Xhance side effects

Get emergency medical help if you have signs of an allergic reaction to Xhance: hives, rash; feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or ongoing nosebleeds;

  • noisy breathing, runny nose, or crusting around your nostrils;

  • redness, sores, or white patches in your mouth or throat;

  • fever, chills, body aches;

  • blurred vision, eye pain, or seeing halos around lights;

  • any wound that will not heal; or

  • signs of a hormonal disorder - worsening tiredness or muscle weakness, feeling light-headed, nausea, vomiting.

Steroid medicine can affect growth in children. Do not use Xhance in a child under 18 years old.

Common Xhance side effects may include:

  • minor nosebleed, burning or itching in your nose;

  • sores or white patches inside or around your nose;

  • cough, trouble breathing;

  • headache, back pain;

  • sinus pain, sore throat, fever; or

  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xhance?

Tell your doctor about all your other medicines, especially:

  • antifungal medicine; or

  • antiviral medicine to treat hepatis C or HIV/AIDS.

This list is not complete. Other drugs may interact with fluticasone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Xhance is a prescription nasal spray used to treat nasal polyps in adults. Flonase Allergy Relief is an over-the-counter (OTC) nasal spray for treatment of allergy symptoms in adults and children 4 years and older. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xhance only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.