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Mepolizumab and Fatigue: What Users Say

Brand names: Nucala

Fatigue: mentioned by 6 users (5.6%)

Based on user experiences from 108 Mepolizumab reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

back pain 13.9%
hair loss 10.2%
headaches 9.3%
tiredness 9.3%
muscle spasms 7.4%
pain 7.4%
joint pain 6.5%
fatigue 5.6%
flu-like symptoms 5.6%
shortness of breath 5.6%

Reviews for Mepolizumab

Commonly mentioned side effects
  • Nic...
  • August 6, 2019

For Asthma "I have been on Nucala for 2 years. I am 41 years old. I’ve had several sinus infections, coughing like crazy, reflux. When the Dr. discovered I had Eosinophilic allergic asthma, he put me on Nucala. About 10 minutes after my injection, I had severe back pain & fatigue. As time goes by, I’m noticing more side effects. I’ve lost 30% of my hair. Severe dry skin on face. Arthritic pain. Headaches. Nucala has helped me tremendously, but I’m so upset about all my thinning/lost hair. I’ve had every blood test done. Thyroid checked. All good. Has to be a side effect. Everyone, PLEASE REPORT ALL YOUR SIDE EFFECTS!!! They need to know so many people are suffering from hair loss, joint pain, fatigue, headaches, muscle spasms, etc. I have to meet with my Dr. again to go over all this."

7 / 10
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  • Lex...
  • March 27, 2017

For Asthma "I've always had bad asthma as a kid. I was constantly put on steroids. My doctor did an IgE test, and mine was over 1,500 (less than 100 is normal). I was put on Nucala for 5 months. At the time of the first injection, my lung function was at 86%, at the time of the fifth injection, I was at around 35%. While on this drug, I felt so sick! Back pain, headache, nausea, fatigue. I felt like I had the flu every day! We decided to stop the drug. (I am still looking for a new treatment option)"

1 / 10
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59 Report
  • Anonymous
  • Taken for 1 to 6 months
  • February 27, 2020

For Eosinophilic Granulomatosis with Polyangiitis "I have been getting the Nucala injections for about 6 months now, and for the first couple of months, I could breathe okay but developed a sinus/ear infection that caused a complete blockage in my ear. I have still been having to use my nebulizer treatments and rescue inhaler and have severe fatigue, headaches, muscle spasms, and back pain. I will not be getting any more of these injections."

2 / 10
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13 Report

Frequently asked questions

  • Sca...
  • August 23, 2020

For Asthma "I have just started Nucala after being on Fasenra for a year (to which I suffered severe side effects), just like what is mentioned in other reviews about Nucala. After reading many reviews, I'm not sure about this drug. I had some fatigue and body aches after the first injection, but not really bad. So I will wait until the next injection to see how it affects me. Hopefully better than the Fasenra."

7 / 10
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  • cou...
  • Taken for 6 months to 1 year
  • February 5, 2021

For Eosinophilic Granulomatosis with Polyangiitis "I've been on Nucala for almost a year now. I did initially notice fatigue and hair loss, but my doctor didn't seem to think it was related and was more due to work stress, however, that has all passed now. I will say that I went from uncontrollable coughing and being unable to breathe after doing minor things (like walking), and now I am inhaler-free! Overall, I have had a good experience so far."

10 / 10
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  • Mor...
  • Taken for 5 to 10 years
  • April 6, 2022

For Eosinophilic Granulomatosis with Polyangiitis "On Nucala ~5 years for Eosinophilic Granulomatosis with Polyangiitis (EGPA). EGPA manifests like asthma, I suspect it is more nuanced. Close enough! I have only used a month-long steroid inhaler to get a handle on a rare extreme seasonal flare-up 2x during the past ~5 years. The source of any side effects is hard to attribute because they require going off meds to narrow the true cause. That is not practical for me. Skin rashes preceded first injections by months and about 2 years of inconclusive dermatology investigations before it abated. Recurs occasionally. Rash vaguely resembles early shingles, and I can't say it's the Nucala, but it may be a component. A general malaise during autumn and winter is common (in my experience). This might be EGPA-related, boosting prednisone for 2 weeks sets things right. I am reactive to prednisone, and it has its own downside. Currently: more frequent aches/back pains this year. COVID shutdown = poor muscle tone could be exacerbating it as much as any drug."

9 / 10
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