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Medroxyprogesterone for Endometriosis User Reviews (Page 3)

Brand names: Provera, Depo Provera, depo-subQ provera 104

Medroxyprogesterone has an average rating of 5.7 out of 10 from a total of 91 reviews for the treatment of Endometriosis. 44% of reviewers reported a positive experience, while 40% reported a negative experience.

Reviews for Medroxyprogesterone

  • sarah
  • June 23, 2018

Depo Provera (medroxyprogesterone) "I HATE this shot, it ruined my life. I had very severe side affects that started the day after I got the shot, and have not stopped. My old provider refused to admit that my pain was due to the shot. I have constant cramping, constant bleeding, migraines, my hair is falling out, my depression is worse than ever, increased anxiety, insomnia, muscle soreness, joint pain and mood swings. I was told that this shot would stop my period, it did not, it just made my period last for 10 months, and it is still going. I will never get this shot again, and I do not recommend this shot for anyone."

1 / 10
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  • Ellis...
  • March 1, 2016

Depo-subQ provera 104 (medroxyprogesterone) "Was on depo shot for 9 months. First I had lighter periods and the endometriosis pain was better. Second month I had light period but it was all month. And then after that the pain was less and there was no bleeding. I started to gain weight. Almost 50 pounds. I already have back pain from herniated disk so I did not go and get my last shot. Endometriosis pain is back ten times worse. And I have been bleeding almost nonstop since September 2015 and it is now March 1 2016. I'm gonna go back to the Dr and have a hysterectomy. I can not stand the bleeding or the pain"

1 / 10
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  • n1723
  • April 9, 2015

Depo-subQ provera 104 (medroxyprogesterone) "I was diagnosed with stage 4 endometriosis at 17 years old. After being on Lupron for 6 months, my doctor proceeded to put me on Depo for the rest of my life until I decide to have kids, and then back on the shot afterwards. I am now on my 5th shot and I've had horrible endometriosis pain(not cramps, very different pain) and have had my period for 2 weeks. I am not sure the Depo is working correctly with my body but other than that, the previous shots have made almost all pain from my endometriosis go away."

7 / 10
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Frequently asked questions

  • Faye
  • Taken for 1 to 6 months
  • April 8, 2019

Depo Provera (medroxyprogesterone) "I have so many mixed feelings!! Too start with the good side effects, my cystic acne is gone!!!!!!! So amazed! I've been struggling so long. My endo pain has gone down tremendously and I'm honestly surprised because I forgot what it felt like to not be severely hurting. I hear a lot that this makes people gain weight but so far I've lost 5 pounds! Now, this why I'm just torn between staying on this or not. I'm only in month one so maybe the negative side effects with go away but they are BRUTAL! It has given me such severe exhaustion that I can't keep my eyes majority of the day (even if I get plenty if sleep)!!! I'm so scared to drive and work is difficult because I will randomly fall asleep! I have to drink so much Caffeine to just barely make it through my day. Also, nausea is BAD! I hardly throw up from it but it is definitely uncomfortable! Also, my mood swings are INSANE! Im honestly embarrassed about it and it's ruining everything right now."

6 / 10
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  • Anonxxx
  • August 23, 2016

Depo Provera (medroxyprogesterone) "Got recommended by the surgeon that did my laparoscopy to try Depo out after severe pain and bleeding being bed bound for atleast 4 days every month and suffering daily from the endo and interstitial cystitis which I have alongside. It has been a god send for me, it does take a toll with mood swings and energy but I think the conditions contribute to that themselves also! I have probably 10 days tops every 3 months before the shot is due that I'll get very bloated (a good 4/5lbs worth on the scales!!) and feel sicky and not right with spotting but as soon as I have the shot again all gone! I'm happy with feeling a bit rubbish once every three months with much less pain rather than every couple of weeks doubled over!! Thank god for depo!!!"

9 / 10
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Are you taking this medicine?

  • ydavis
  • Taken for 1 to 6 months
  • November 8, 2016

Provera (medroxyprogesterone) "I have been on Provera 10mg for almost 3 months now. My first monthly period was painful and heavy. My second was a regular plus I clotted a lot. With my 3 rd cycle I only spotted off and on for 3 days. I haven;t seen a cycle since. Besides the cramps and the spotting every now and then. I highly recommend this medicine. I have to take provera 10mg daily for 6 months to remove pre cancerous cell off my uterus. I have a 12yrs old son and now me and my husband are praying for another child which will be his first biological child. Has anyone besides me missed a cycle while on Provera. I have taken two home pregnancy tests a week apart and they both said the same thing ( Negative)"

8 / 10
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  • Shell...
  • Taken for 2 to 5 years
  • August 27, 2015

Depo-subQ provera 104 (medroxyprogesterone) "I started on the shot in 2013 to help with the pain from endometriosis my cycle was pretty regular but I was in constant pain. The first year went pretty good with no side effects after the first year I started bleeding heavily and continued to for three months I was put on estrogen and the depot shot went from every twelve weeks to ten weeks after three months of this I under went a uterine ablation the bleeding stopped but the pain from the endometriosis is still an every day problem and I have put on 45lbs my blood pressure has went up. My doctor and I have decided the depot shot is no longer an option. the shot worked I suggest monitoring your health while on it."

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  • Megap...
  • April 5, 2015

Depo-subQ provera 104 (medroxyprogesterone) "I started my first injection over a month ago for my severe endometriosis. The day after I started noticing terrible mood swings, as did my family. I would get angry and freak out at the tiniest things. Usually cry over nothing. It lasted for about 4 weeks and my moods have simmered down, but not as much as they should. He said to consider Zoloft, because my hormone levels aren't normal and I have anxiety. I have been spotting everyday for the whole month, and still notice some pain, but not as bad as it was before I started the injections. My obg said this was normal, and assured me after the third injection this would go away. Hopefully it does. I can now say I'm not living in hell 12 times a year."

7 / 10
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  • lisa
  • Taken for 1 to 6 months
  • April 16, 2019

Depo Provera (medroxyprogesterone) "I had Depo-Provera for only 6 months. It was the worst thing literally. I got it in the first place to get rid of my period since lately I wouldn’t be able to go out of the bed and I was missing too much work and daily activities because of it, so my doctor recommended it. In less than a month, my weight went up to 10lbs out of nowhere, even if I tried to exercise and eat healthier, my weight would still be going up. I had terrible acne that left me scars on my face, no sexual drive at all, total dryness down there, horrible bone/joint pain (even while taking the corresponding dose of calcium supplements), even depression. The only good thing was being able to not suffer from my periods at all but now my body is a disaster. I wouldn’t recommend it to anyone"

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  • Katie
  • Taken for 1 to 2 years
  • August 8, 2021

Depo Provera (medroxyprogesterone) "I freaked out reading reviews the first time I got the injection, but I've had a great experience. We're all different, and I just happen to be someone who didn't have a good experience with nexplanon, but loves Depo. I'm going on my second year now, and I've gained no weight. Most importantly, my endo pain is finally gone, and I feel myself. It even helped my insomnia, which I had no idea was related to hormones. The two side effects I've dealt with was smaller breasts for a couple months after the first injection, and irritability the day after I get the injection. That's really the worst of it."

10 / 10
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  • HML
  • Taken for 1 to 6 months
  • December 7, 2015

Depo Provera (medroxyprogesterone) "I was recently put on depo provera as a last-ditch effort prior to undergoing a full hysterectomy to relieve serious pain from endometriosis. While it has been effective for relieving the pain, I have been heavily spotting or more for over 2 months now... every day. I decided not to get another shot and I am now experiencing random horrible stabbing pains in my ovary (not like the endometriosis pain). Pain aside... 2 months of feeling too gross to have sex - I feel bad for my husband! I was on depo for years during my younger years and never had any issues. I stopped taking it because I thought I was going to be able to have children; that turned out to not be the case, so I thought it couldn't hurt to try it again... bad choice!"

2 / 10
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  • bek
  • Taken for 6 months to 1 year
  • August 22, 2021

Depo Provera (medroxyprogesterone) "I got my first injection in January this year for extreme periods (lasting months at a time) and cramping (so bad that I used to faint), doctors didn’t want to do endometriosis discovery surgery so they put me on the depo-provera instead. Within 2 weeks of the first injection, my personality completed changed; severe depression, zero sex drive, anxious, irritable, gained 35 pounds, extreme fatigue - the list goes on. I stayed on the injection because there was nothing else the doctor would do. I can’t leave the house without putting in an “emergency tampon” in case I start gushing blood in the grocery store. I still have severe cramps and crazy random bleeding and the depression is getting worse. I finally switched doctors and have started transitioning off the injection and onto 5mg progesterone instead. Do not get this injection unless ABSOLUTELY necessary. Totally ruined a year of my life."

1 / 10
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  • Jacinta
  • Taken for 6 months to 1 year
  • October 23, 2019

Depo Provera (medroxyprogesterone) "Have used used depo provera for 9 months without any side effect but after stopping using it March 2019 haven't received back my period up to October 2019 where I have seen some blood spotting for like 17 days but not continuous. My question is when will I get my normal periods back because I want to conceive??"

9 / 10
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  • Tae-Tae
  • December 9, 2015

Depo Provera (medroxyprogesterone) "I have was dx with endometrosis back in 2010. I have had 4 chest tubes surgeries within 3 years. I was also dx with catamenial puemothorax which you can google to get more info about but it has a lot to do with my period etc it all goes together. But I have been on birth control pills, lupron and now on the depo. And I must say the only think that helps was the lupron , besides of the side effects of hot flashes, cold sweats etc. But the pill was a no go. I didn't like how it made me feel and I have been on the depo shots for a few months but I must say it worked in the 1st few months but now i have been bleeding for he last 4 months nonstop and I am just stop everything cause I'm so over with trying different things - its so frustrating."

5 / 10
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  • Jojo...
  • March 10, 2017

Depo Provera (medroxyprogesterone) "I have been on depo for a year and 3 months and have had no issue until now. It worked perfectly after I had my laparoscopy when I was diagnosed with stage I endometriosis. Now after this past month I've had bleeding and I have had 4 flare ups.... more than I had before my laparoscopy had been done. Went to the doctor with severe abdominal pain, nonstop bleeding and he had to take every gynecological test your mind can come up with, all of them came back negative. Doc is suggesting I go onto Lupron with add-back therapy since it's a lot stronger. Didn't have any side effects with the depo at all. I just hope with my new medicine administration of Lupron on the 24th of this month I will feel some much needed relief"

2 / 10
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  • Anonymous
  • April 1, 2010

Depo Provera (medroxyprogesterone) "I have been on this for the better part of the last 10 years! I loved the convenience of only having to deal with it 4 times per year. I also was lucky enough to rarely have a period (maybe light spotting once a year). However in the last 6 months, I've been having heavy, irregular periods so I am looking into different treatment but I will miss the ease of the shot!"

9 / 10
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  • IZza
  • Taken for 2 to 5 years
  • June 25, 2018

Depo Provera (medroxyprogesterone) "I have endometriosis diagnosed 6 yrs ago via laparoscopy, but used depo for birth control at a young age at age 18 yrs old. I used it for 2 years (no periods) gain 30lbs, depression, then had a hard time getting pregnant. I’m not sure if depo had anything to do with getting endometriosis later in life. Now, I’m 40yrs old and I’m taking it again for endometriosis, it helped the pain, no periods, some spotting, but no sex drive, I have mood swings, and hungry all the time. I decided to have a hysterectomy soon, tired of endometriosis and periods. Good luck people."

7 / 10
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  • Thest...
  • Taken for 1 to 6 months
  • October 21, 2016

Depo Provera (medroxyprogesterone) "For starters, I've been living through endo for 9 years now. But, after two surgeries for ectopic pregnancies my periods and pelvic pain hit an all time high so I decided to give the depo shot a go. Day three after getting the shot the bleeding/spotting started and never let up. I was constantly wearing a pad or panty liner. No bueno. Along with the spotting was off and on cramping, GI issues, and an insatiable appetite. I was basically having my period every single day. This went on for 4-5 months and let me just say to women worried about gaining weight, NO! Try something else. I gained 23 freaking pounds and now my body doesn't want to let go of that weight. All in all this did nothing but make my severe periods moderate and constant."

5 / 10
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  • Moody
  • Taken for 1 to 6 months
  • April 19, 2016

Depo Provera (medroxyprogesterone) "I've had a horrible experience with this shot. I only wish I have read all of the horror reviews before getting it to save myself a year of hormonal problems and a scarred face from a cystic acne breakout. Once I got the shot I got online and started reading the reviews and was horrified because part of me knew I made a huge mistake- and oh did I. I bled for 6 months straight! I was practically drinking liquid iron by glasses because of how much blood I was losing after getting the shot. I got the shot BECAUSE of painful and heavy bleeding periods! But it only made it much much worse. I finally went back to my docs, they put me on patch that stopped the bleeding"

1 / 10
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  • Purpl...
  • Taken for 6 months to 1 year
  • September 25, 2021

Provera (medroxyprogesterone) "I am 48 years old and have been on Provera on and off for a year. About a year ago I had my period and it wouldn't stop it was very heavy with large blood clots so the doctor prescribe Provera to help stop the bleeding it did two days after taking it. My Obgyn suggested that I have the Mirena IUD. I did so and have had spot bleeding sometimes really heavy since having it placed in. I had to have it removed a month after due to the fact that my body was rejecting it and I started breaking out in rashes. That was on Sept 17 and I have been on Provera 10mg one a day its been 7 days and I am still bleeding heavily with huge clots. I contacted my OBGYN and she said to give it a couple of more days and if it doesn't stop I am going to call her back I am so done with this .I have been bleeding non-stop since August 6th. I feel like I have no life I'm attached to the toilet constantly and constantly having to shower because it smells so bad and I feel so dirty. I hope Provera starts to help soon."

4 / 10
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  • Kay-R...
  • October 15, 2015

Depo Provera (medroxyprogesterone) "I loved how convenient this was, one shot every three months, but, look into ANY birth control before you put anything in your body. I thought all was well for about a week and then I started heavily bleeding. I bled nonstop for the whole three months, and my gyno told me that the bleeding wouldn't stop anytime soon, even if I switch birth control. I've read that the bleeding is caused by the progesterone only in the shot, so some women need an estrogen supplement or a different method of birth control that contains estrogen (I'm on the patch now) to counteract the bleeding. My cramps were not as bad on the shot, but, they were still there and occurred more often than before I started on the shot."

3 / 10
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  • Bleedy...
  • Taken for 1 to 6 months
  • December 11, 2019

Depo Provera (medroxyprogesterone) "NEVER EVER TAKING THIS INJECTION AGAIN. I AM BLEEDING SO BAD IDON'T THINK I WILL HAVE ANY BLOOD LEFT & IT WONT STOP. I had the shot in November 2019. I have other symptoms as well. Pls pls pls stop bleeding & for me I've loathed periods & this is causing my life to be miserable. And like all the others my sex drive gone. I will NOT get the 2nd shot & will be telling my Dr "Imagine bleeding from your butt & wearing multiply pads everyday to ensure no accidents happen & for this to last non stop". My Dr said by the 2nd & 3rd shot your period would stop, WHAT ?WOULD HE PUT UP WITH THAT!!. "

1 / 10
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  • InPai...
  • December 22, 2017

Depo Provera (medroxyprogesterone) "I was on the depo for a few months and hated it. I got it to help with my endo and it did help a little. At first I had a heavy period for 6 months they pain was still there but not as bad and I was able to go into work fine. I stopped taking it though because my period kept getting heavier and heavier and I can't afford it without healthcare insurance. Once I stopped getting depo, my period had stopped altogether. I felt so good. Pain was rare. That was eight months straight. Well I recently got my period back. I've actually had 2 heavy periods in ONE month. Like extremely heavy bleeding through all my clothes. I'm changing super tampons every hour. The pain is so much worse than it has ever been before. Idk what to do. "

3 / 10
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  • BABWP...
  • Taken for 1 to 6 months
  • January 25, 2018

Depo Provera (medroxyprogesterone) "I've always had very heavy periods. I have 24/7 severe pelvic pain, worse with periods. I've tried 2 surgeries, 4 rounds of Lupron, & bc pills, none of which helped the pain but pills made periods fewer & Lupron made them stop. Dr recently had me to try Depo & told me I wouldn't have a period! I had 2 periods before 2nd shot. Dr said most people don't have periods but those that do are lighter. I told her they were just as heavy, more painful, & lasting 2-3 weeks! She made me do a 2nd shot. I had another VERY heavy & painful 2 week long period! My PA wanted me to stop the shots & start a 3 month pill pack immediately, even though it wasn't time for my next shot. After 2 pills, my period stopped!"

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  • Birdly
  • Taken for less than 1 month
  • January 9, 2022

Depo Provera (medroxyprogesterone) "Although my Depo experience was in 2008, I thought I would chime in. I did not want to go on depo provera, I had been suffering with endometriosis for years and I had major concerns as I also suffer from multiple mood issues. I finally relented and booked a desperate appointment. I was to have 6 injections. When the nurse injected my first dose, her exact words were “you’re going to go crazy for the first few weeks.” WOW, great to know now that you’ve just injected me. Exactly 2 weeks after my injection without thinking I had a suicide attempt. I had also written a suicide note which I have no memory of. I’m not sure how, but I woke up the next day. Although very sick, I faked health to family and friends but could not get out bed. I was rushed to emerg a day later where the doctors where shocked I was alive. Took a year to recover."

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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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