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User Reviews for Medroxyprogesterone to treat Endometriosis (Page 3)

Also known as: Depo-Provera, Provera, depo-subQ provera 104

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Medroxyprogesterone Rating Summary

User Ratings
17% (14)
17% (14)
10% (8)
8% (7)
4% (3)
4% (3)
0% (0)
7% (6)
6% (5)
28% (23)
5.6/10 Average Rating
83 ratings from 86 user reviews

Compare all 76 medications used in the treatment of Endometriosis.

Reviews for Medroxyprogesterone

Kay-Rosee October 15, 2015

Depo-Provera (medroxyprogesterone): “I loved how convenient this was, one shot every three months, but, look into ANY birth control before you put anything in your body. I thought all was well for about a week and then I started heavily bleeding. I bled nonstop for the whole three months, and my gyno told me that the bleeding wouldn't stop anytime soon, even if I switch birth control. I've read that the bleeding is caused by the progesterone only in the shot, so some women need an estrogen supplement or a different method of birth control that contains estrogen (I'm on the patch now) to counteract the bleeding. My cramps were not as bad on the shot, but, they were still there and occurred more often than before I started on the shot.”

3 / 10
Shell7seas · Taken for 2 to 5 years August 27, 2015

Depo-Provera (medroxyprogesterone): “I started on the shot in 2013 to help with the pain from endometriosis my cycle was pretty regular but I was in constant pain. The first year went pretty good with no side effects after the first year I started bleeding heavily and continued to for three months I was put on estrogen and the depot shot went from every twelve weeks to ten weeks after three months of this I under went a uterine ablation the bleeding stopped but the pain from the endometriosis is still an every day problem and I have put on 45lbs my blood pressure has went up. My doctor and I have decided the depot shot is no longer an option. the shot worked I suggest monitoring your health while on it.”

Allishaew August 13, 2015

Depo-Provera (medroxyprogesterone): “I have been on the shot for almost two months and I absolutely hate it. When I got the shot I was actually due for my period and never got it. I ended up getting my period about 2 weeks ago and have not stopped bleeding. I can not have sex, I can't wear white pants because it's so heavy, I can't go to the bathroom ( number 1 or number 2) because it hurts so bad, I have had horrible cramps, I don't sleep, I'm exhausted all the time, and I am constantly feeling grumpy. At this point I almost feel like nothing is going to help my endometeriosis, I'm 22 years old and due to be married in a month and I can't even have sex because it hurts so bad.... I would not recamend this shot, it's a waste of time and causes false hope.”

1 / 10
darlastarbuck July 16, 2015

Provera (medroxyprogesterone): “I took Provera pills daily to stop my periods to kill the monthly pain. I chose pills over the shot so I could have control of deciding when/if I wanted to stop. I took the pills for 6 months. The first month I had lots of breakthrough bleeding - basically I was slowly bleeding for a few weeks. After that I had no period, no spotting, no cramps - that part was FANTASTIC! However, for me the side effects were severe and unlivable. I had insomnia (waking in the night) every night. I had night sweats every night. I gained a little weight. I had extreme vaginal dryness/painful intercourse which was a first ever for me. My sex drive was non-existent and my acne and facial hair (PCOS) got much worse.”

3 / 10
thunderseed July 16, 2015

Depo-Provera (medroxyprogesterone): “I've been taking Depo for about 15 years and it's never given me any negative symptoms. I went on it very young because I had painful abnormal periods. I haven't had any menstral cycles the whole time, which means no pain. I've never struggled with weight gain. My bones are healthy and strong, in fact I've never had a broken bone in my entire life. It's highly effective as a birth control and I am very happy with it.”

10 / 10
n1723 April 9, 2015

Depo-Provera (medroxyprogesterone): “I was diagnosed with stage 4 endometriosis at 17 years old. After being on Lupron for 6 months, my doctor proceeded to put me on Depo for the rest of my life until I decide to have kids, and then back on the shot afterwards. I am now on my 5th shot and I've had horrible endometriosis pain(not cramps, very different pain) and have had my period for 2 weeks. I am not sure the Depo is working correctly with my body but other than that, the previous shots have made almost all pain from my endometriosis go away.”

7 / 10
Megaphone1220 April 5, 2015

Depo-Provera (medroxyprogesterone): “I started my first injection over a month ago for my severe endometriosis. The day after I started noticing terrible mood swings, as did my family. I would get angry and freak out at the tiniest things. Usually cry over nothing. It lasted for about 4 weeks and my moods have simmered down, but not as much as they should. He said to consider Zoloft, because my hormone levels aren't normal and I have anxiety. I have been spotting everyday for the whole month, and still notice some pain, but not as bad as it was before I started the injections. My obg said this was normal, and assured me after the third injection this would go away. Hopefully it does. I can now say I'm not living in hell 12 times a year.”

7 / 10
Judii47 March 6, 2015

Depo-Provera (medroxyprogesterone): “I've had endometriosis my whole life... Six surgeries.. I was on Lupron 2x.... Birth control pills.... Finally the depo was my last resort.... The first time it made me bleed everyday for 7 months... I didn't give up on it... It made me gain weight because it increases your appetite and u don't realize it until u go off of it.... I still didn't give up... I've been on it now for 5 years and I have joined weight watchers and increased excercise..... I have not had a period in 5 years..... I don't miss the agony ... The pain... The hospital visits.... Being bed ridden for 3 days a month.... I love the Depo...and now I'm making progress with losing weight so I'm happy...”

10 / 10
Lea31 November 14, 2014

Depo-Provera (medroxyprogesterone): “I have been on it now for 10 yrs & love it. Before I would be in bed for weeks with bad cramps, it was destroying my life. I get little cramping well the shot is due but I can live with that.”

8 / 10
Cytogirl · Taken for less than 1 month June 6, 2014

Depo-Provera (medroxyprogesterone): “I refused to get the shot because I had researched Depo for a paper in college, but it came down to Depo or severe anemia. So I received the shot and the next morning I was praising Jesus because the shot got rid of the almost constant back pain I'd had for 2 years since delivering my twins. Doctors kept telling me it was a sprained muscle only it never healed, now I believe it was endometriosis.”

10 / 10
Alexandria R March 24, 2014

Depo-Provera (medroxyprogesterone): “I've only had one shot so far, but it has now been almost two months since I got the shot. I heard good things about this shot, and I was hoping it would take care of my really severe cramps! I skipped my period the month after I got the shot, but then the month after that, it came back. I would say my period is a lot lighter now, but it has lasted twice as long as it normally does. My cramps have been better, as they are now tolerable. But, they are still there. I have noticed a really big change in mood swings and emotions. I get in cranky moods WAY more often. At least once a day. I also have noticed that I cry super easily now, even over little things. Again though, it has only been two months. Maybe things will start to get better.”

7 / 10
TN mom March 5, 2014

Depo-Provera (medroxyprogesterone): “I was hesitant to try this but I really didn't want to have a hysterectomy. I've already had one ovary/tube out due to my endometriosis. I was recently diagnosed with also have adenomyosis now. It was Depo-Provera, Lupron or a hysterectomy. I read so many terrible reviews that it had me nervous but I tried it anyway. I've gained a few pounds but am also 45 and lazy so that may be the more likely culprit. My acne is actually gone. I've had no endometrosis symptoms. My hair is slightly thicker. For me it's been a miracle. We're hoping to be able to have these results until menopause hits.”

9 / 10
nkb · Taken for 1 to 2 years February 8, 2014

Depo-Provera (medroxyprogesterone): “My doctor put my on Depo-Provera after laproscopy for endometriosis. I had irregular periods after the first shot and after the second I remember I had one period that seemed to last for a month. This is a known side effect and as promised it went away after the third shot. I haven't had my period now in about a year. I also haven't had any debilitating endometriosis symptoms either. I think I gained about 5 lbs total but then again I'm also in my 40s and that could simply be a part of aging. I am a big fan. It gave me nearly total relief after getting through the first 6 months.”

9 / 10
missbones · Taken for 1 to 6 months January 12, 2014

Depo-Provera (medroxyprogesterone): “I have severe endometriosis and a lot of scar tissue from laparoscopic surgery four years ago when they removed two large cysts that were wrapped around my fallopian tube, which I lost. Then last year my right ovary hemorrhaged and I bled internally for two days, two weeks ago I had a cyst rupture on my ride side. I am SO done with being in pain. I've been in non stop monthly HELL for the past 4 years! So I got back on the Depo-Provera shot. I took it when I was a teenager for two years for my endo pain. And I loved it. I am so glad to be back on it. I am also on a seizure medicine that makes birth control ineffective, but has no effect on the Depo shot, so that is another plus.”

10 / 10
Scarlettsky November 7, 2013

Depo-Provera (medroxyprogesterone): “When I was 7 I started puberty, I started my periods and all the other signs of becoming a "young woman" and I have been having pain since then on, I've had 2 operations, abnormal periods and extensive ones that have lasted 8 weeks and 21 weeks. I'm 18 and have I've been on this injection for nearly 2 months and I've had nothing but pain, I'm heavier on my period than I've ever been and I'm constantly tired, moody, emotional and sick. I can't hold a meal down and I've lost 2 stone because of this and am now classed as underweight. I can't even hold anti-sickness tablets down. I was told to continue to take the pill and then during my break I shouldn't get my period, but I have and they've been causing that much pain can't even walk properly”

2 / 10
Upward Spiral · Taken for 10 years or more October 13, 2013

Depo-Provera (medroxyprogesterone): “I have been on Depo now for over 20 years - I should be paid to be their poster child. It was the miracle medicine for me and my body. After 10 horrific years of monthly hell, I started Depo. Immediately, the periods went away, my hormones balanced and I literally regained my life. I have had no long term effects, no weight gain, no side effects at all. For the right person, this works amazingly well. For others, it does not. But it IS worth a try!”

10 / 10
Sammmm · Taken for 1 to 2 years June 30, 2013

Depo-Provera (medroxyprogesterone): “I got on the shot in April 2012 for many reasons. 1. I worked at the YMCA in the pool & I didn't want to worry about bleeding 2. My cramps were torture! I wouldn't be able to get out of bed. During the first month or so I did spot and have some cramps but they eventually stopped. I love the shot. I did gain some weight but that was some what my fault because I stayed unactive. But with a good diet and some exercise you won't gain weight! Recommend it to everyone!”

9 / 10
Refinnejean April 18, 2013

Depo-Provera (medroxyprogesterone): “I love the Depo shot. No side effects at all. I read so many negative reviews before I took my first shot. I have experienced none of the side effects I read about in the reviews. I have not had any break through bleeding as many people described. I have had no periods after the first shot. Before Depo, I had painful cramps before and during my period. No pain and no weight gain. I am so pleased with this form of birth control.”

10 / 10
clarissa ann January 10, 2013

Depo-Provera (medroxyprogesterone): “I got on this as a teenager for my endometriosis. Besides spotting for the first four months I have had no ill effects. No weight gain. In fact its hard to keep weight on. I got off of it to have my kids. Now I'm back on it. It's so much easier raising toddlers without cramps and random bleeding. I recommend it highly. Don't let bad experiences scare you. I actually had a horrible time with the pill. I love my Depo shots!”

10 / 10
Melly ke · Taken for 2 to 5 years January 3, 2013

Depo-Provera (medroxyprogesterone): “On Depo for approximately 10 yrs go. No problems or side-effects. No period for 3 yrs-HEAVEN! Got off of it. Doctor said since I had no bleeding last time would be okay to do again. Got shot a month ago-the week I was supposed to start. First week was great. No bleeding but have had continual spotting every day since (3wks). Hopefully it will stop soon. ”

8 / 10
annajw July 25, 2012

Depo-Provera (medroxyprogesterone): “It has been almost 6 months since my shot and I have been on my period the whole time. I gained 45 pounds and I was the most depressed I've ever been. I went insane with mood swings, my already bad pain got worse, and I had head splitting migraines among other things. I don't recommend it to anyone. It should come with a prescription for Xanax and some weight loss pills to try to stay on top of things.”

1 / 10
Anonymous · Taken for 1 to 2 years June 9, 2012

Depo-Provera (medroxyprogesterone): “After two months on the shot I started to bleed, spotting and breakthrough bleeding is not uncommon but this was much more. My doctor kept telling me to stick it out that it can take up to 12 months to stop, after 13 months of almost everyday bleeding we decided to call it quits. It does wonders for some but didn't for me.”

1 / 10
Anonymous October 1, 2011

Depo-Provera (medroxyprogesterone): “I've had endometriosis for over 20 years and have had about enough of the pain and the accompanying anemia from blood loss. In the last 5 years my blood loss from the endometriosis has increased tenfold and I have developed severe iron deficiency anemia. My OB/GYN and I decided to try Depo again (last time was in the early 90s) and I had my first shot in July of 2011. August was HEAVEN! No period and my iron levels tested almost normal. I was human again! Now it's September and I have had a "period" (in quotes, because it's more like a normal woman's period) for over 15 days and I feel like I have been hit by a Mac truck. No endometriosis pain, but my iron levels are so low from bleeding that all I can do is sleep. When it works, it's fantastic.”

8 / 10
Anonymous September 26, 2011

Depo-Provera (medroxyprogesterone): “I've only taken one shot, it has been somewhat of a last ditch effort to provide some pain relief from endometriosis and polycystic ovaries. The first month was great, no pain and very little spotting. The second month has been horrible, I had a period for 2 1/2 weeks and the other 1 1/2 I had spotting along with horrible (at times) pain that even Lortab won't fully control. Doctor gave me estrogen to stop bleeding and that took a week. As of now I am not taking another shot. I told my husband that I can feel this bad for free. If this third month goes okay I may reconsider. I've tried everything and its bad...looks like hysterectomy is next step.”

1 / 10
mattert September 8, 2011

“I have irregular periods due to the endometriosis. I can bleed for weeks and heavy. My doctor gave me the prescription for medroxyprogesterone a long time ago and it was like a miracle for me. By the third day out of the ten that I had to take it for my long awaited bleeding stopped. I have never encountered any side effects from the medication at all and I have had to take it on many occasions. I am very grateful for the manufacturer of this medicine. I don't know where I would be without it today. So thank you so much.”

10 / 10

Learn more about Endometriosis

IBM Watson Micromedex

Symptoms and treatments

Mayo Clinic Reference

ICD-10 CM Clinical Codes (External)