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User Reviews for Medroxyprogesterone to treat Endometriosis (Page 2)

Also known as: Depo-Provera, Provera, depo-subQ provera 104

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Medroxyprogesterone Rating Summary

User Ratings
17% (14)
17% (14)
10% (8)
8% (7)
4% (3)
4% (3)
0% (0)
7% (6)
6% (5)
28% (23)
5.6/10 Average Rating
83 ratings from 86 user reviews

Compare all 76 medications used in the treatment of Endometriosis.

Reviews for Medroxyprogesterone

IZza · Taken for 2 to 5 years June 25, 2018

Depo-Provera (medroxyprogesterone): “I have endometriosis diagnosed 6 yrs ago via laparoscopy, but used depo for birth control at a young age at age 18 yrs old. I used it for 2 years (no periods) gain 30lbs, depression, then had a hard time getting pregnant. I’m not sure if depo had anything to do with getting endometriosis later in life. Now, I’m 40yrs old and I’m taking it again for endometriosis, it helped the pain, no periods, some spotting, but no sex drive, I have mood swings, and hungry all the time. I decided to have a hysterectomy soon, tired of endometriosis and periods. Good luck people.”

7 / 10
sarah June 23, 2018

Depo-Provera (medroxyprogesterone): “I HATE this shot, it ruined my life. I had very severe side affects that started the day after I got the shot, and have not stopped. My old provider refused to admit that my pain was due to the shot. I have constant cramping, constant bleeding, migraines, my hair is falling out, my depression is worse than ever, increased anxiety, insomnia, muscle soreness, joint pain and mood swings. I was told that this shot would stop my period, it did not, it just made my period last for 10 months, and it is still going. I will never get this shot again, and I do not recommend this shot for anyone.”

1 / 10
sarah · Taken for 6 months to 1 year June 21, 2018

Depo-Provera (medroxyprogesterone): “I got the depo shot as an easy form of birth control seven months ago and I hate it. I have had constant bleeding, constant cramping, worsening depression, worsening anxiety, my hair is falling out and I am having migraines frequently. I would not recommend this for anyone, especially not anyone who suffers from anxiety or depression.”

1 / 10
Anonymous · Taken for 2 to 5 years May 25, 2018

Depo-Provera (medroxyprogesterone): “In the past, I have tried various pills and the patch. With the Depo shot, it was nice to only have to get it every 3 months. The first 6 months or so, I had irregular periods, but after that my periods stopped completely. I was on the Depo shot for over 3 years and had more pros than cons. The only downside for me was the weight gain. I stopped taking the shot so my weight would come didn't. I would advise extremely healthy diet and exercise if you want to be on the Depo shot.”

8 / 10
BABWPrincess · Taken for 1 to 6 months January 25, 2018

Depo-Provera (medroxyprogesterone): “I've always had very heavy periods. I have 24/7 severe pelvic pain, worse with periods. I've tried 2 surgeries, 4 rounds of Lupron, & bc pills, none of which helped the pain but pills made periods fewer & Lupron made them stop. Dr recently had me to try Depo & told me I wouldn't have a period! I had 2 periods before 2nd shot. Dr said most people don't have periods but those that do are lighter. I told her they were just as heavy, more painful, & lasting 2-3 weeks! She made me do a 2nd shot. I had another VERY heavy & painful 2 week long period! My PA wanted me to stop the shots & start a 3 month pill pack immediately, even though it wasn't time for my next shot. After 2 pills, my period stopped!”

1 / 10
InPainNoGain December 22, 2017

Depo-Provera (medroxyprogesterone): “I was on the depo for a few months and hated it. I got it to help with my endo and it did help a little. At first I had a heavy period for 6 months they pain was still there but not as bad and I was able to go into work fine. I stopped taking it though because my period kept getting heavier and heavier and I can't afford it without healthcare insurance. Once I stopped getting depo, my period had stopped altogether. I felt so good. Pain was rare. That was eight months straight. Well I recently got my period back. I've actually had 2 heavy periods in ONE month. Like extremely heavy bleeding through all my clothes. I'm changing super tampons every hour. The pain is so much worse than it has ever been before. Idk what to do. ”

3 / 10
Jamielees00 · Taken for 5 to 10 years October 29, 2017

Depo-Provera (medroxyprogesterone): “DO NOT TAKE THIS DRUG!!! From 1999-2005 I was on depo for birth control. Being young I thought this was the easiest solution and a better alternative to the pill everyday. I injection every 3 months. Sounds great right. Well, in 2005 Pfizer legally had to put a black label warning on their product warning that it may cause osteoporosis. Fast forward to today and I am now diagnosed with MS, there have been claims and speculation about Depo that it’s linked to neurological problems. I am 36 years old and in the next year or so I will have to remove all my teeth and get dentures because there is so much bone density loss in my mouth. Two months ago I had surgery for endometriosis. Osteoporosis testing tomorrow, this drug is not the solution.”

1 / 10
Sunshine1541 · Taken for less than 1 month August 17, 2017

“I've missed periods for 2 years since stopping birth control and now been diagnosed with PCOS, and recently after an appendectomy, surgeon noticed signs of endometriosis. The idiotic new obgyn I went to had No idea what Either were. While even training a student, I heard a Lonng 45 min+ conversation between her and a head doctor who was trying to teach her what is was..while I was trying to leave, she came in and said endo was blood that gets stuck internally in wrong places... uggh my friend knew MUCH more about it and informed me the textbook definition etc. I've been on the 10 day med. to prompt a period so my lining doesn't build up too thick n cause cancer it's not working tho two 10 day scripts and nothing but sore huge breasts. I think its called methohydroxidone”

1 / 10
FriedaKahlo · Taken for 6 months to 1 year July 5, 2017

Depo-Provera (medroxyprogesterone): “This is the only medicine that I've tried that controls my endometriosis symptoms. It has been a MIRACLE. The first shot caused intense hunger that lasted about a month. But I have not experienced any weight gain and have in fact lost 10 pounds with diet and exercise while on depo. The first month also caused some bad adult acne but I got that under control with acne washes. I've had some occasional light spotting that requires an ultra thin pad for a day or two. There was 1 bad period when I was due for the second shot, but since then, I haven't had any periods at all. It's been 6 months and this shot allows me to live a normal life, make plans, and work a normal job without having to miss numerous days.”

10 / 10
Loune June 29, 2017

Depo-Provera (medroxyprogesterone): “I recently tried depo provera for my endo, and it worked great for my heavy periods and also the pain. I barely have any flare ups like before. But my hormones are going crazy or I'm going crazy. I'm irritable all the time and I get so mad over nothing. Wondering whats worse to go through pain or the damn moods swings.....”

7 / 10
Jojo Toews March 10, 2017

Depo-Provera (medroxyprogesterone): “I have been on depo for a year and 3 months and have had no issue until now. It worked perfectly after I had my laparoscopy when I was diagnosed with stage I endometriosis. Now after this past month I've had bleeding and I have had 4 flare ups.... more than I had before my laparoscopy had been done. Went to the doctor with severe abdominal pain, nonstop bleeding and he had to take every gynecological test your mind can come up with, all of them came back negative. Doc is suggesting I go onto Lupron with add-back therapy since it's a lot stronger. Didn't have any side effects with the depo at all. I just hope with my new medicine administration of Lupron on the 24th of this month I will feel some much needed relief”

2 / 10
CokoPicasso · Taken for 6 months to 1 year February 3, 2017

Depo-Provera (medroxyprogesterone): “Suffered with super heavy, painful periods for YEARS. Was finally diagnosed with Endometriosis and an ovarian cyst 9 months ago. Absolutely NO cramping after 2nd shot, no more periods, and I'd probably rate this a 10 if it wasn't for the weight gain (not massive, but still . . . ) and low sex drive. Never had an issue with naturally occurring lubrication (if that's what you want to call it) but I do now. And I don't have orgasms like I used to. Worth it? Definitely YES, because like I said, no more menstrual pain AND I don't have to buy tampons anymore when I was used to using super plus size ones at least 6-10 times a day. FYI my insurance wouldn't cover it for a medical condition, but DOES cover it for birth control. Go figure.”

An Unhappy Customer December 22, 2016

Depo-Provera (medroxyprogesterone): “This has been a nightmare. I got the shot to ease pelvic pain my provider suspected was due to endometriosis. At first, I felt like I had the flu for a week or two. Almost exactly a month after getting the shot, I started getting a lot of spotting, and had to wear a pad constantly. After a week of spotting, it became a full-blown, heavy period, and my pelvic pain came back worse than ever before along with severe cramps, muscle aches, and even trouble using the bathroom because of the pain. The pain is far worse at night. I can't sleep. Ibuprofen and heat packs no longer help. It's been three weeks. My doctor isn't sure what to do, and others I've talked to said it took several months for the pain from the depo shot to go away. I'm in agony.”

1 / 10
ydavis · Taken for 1 to 6 months November 8, 2016

Provera (medroxyprogesterone): “I have been on Provera 10mg for almost 3 months now. My first monthly period was painful and heavy. My second was a regular plus I clotted a lot. With my 3 rd cycle I only spotted off and on for 3 days. I haven;t seen a cycle since. Besides the cramps and the spotting every now and then. I highly recommend this medicine. I have to take provera 10mg daily for 6 months to remove pre cancerous cell off my uterus. I have a 12yrs old son and now me and my husband are praying for another child which will be his first biological child. Has anyone besides me missed a cycle while on Provera. I have taken two home pregnancy tests a week apart and they both said the same thing ( Negative)”

8 / 10
Thestruggleiswhat? · Taken for 1 to 6 months October 21, 2016

Depo-Provera (medroxyprogesterone): “For starters, I've been living through endo for 9 years now. But, after two surgeries for ectopic pregnancies my periods and pelvic pain hit an all time high so I decided to give the depo shot a go. Day three after getting the shot the bleeding/spotting started and never let up. I was constantly wearing a pad or panty liner. No bueno. Along with the spotting was off and on cramping, GI issues, and an insatiable appetite. I was basically having my period every single day. This went on for 4-5 months and let me just say to women worried about gaining weight, NO! Try something else. I gained 23 freaking pounds and now my body doesn't want to let go of that weight. All in all this did nothing but make my severe periods moderate and constant.”

5 / 10
Caliblue7 · Taken for 1 to 2 years September 27, 2016

“I've been on the pill form (Provera), 30mg once a day for almost 15 months now and have gained nearly 100 lbs. I kid you not. My doctor thought it was my thyroid but it was not. All of my hormone levels were normal when tested. It has to be the medicine. It has a bad reputation for weight gain and I have never struggled with weight in my entire life before getting on this med. I was put on it for endometriosis and ovarian cysts, but I am going to talk to my Obgyn about switching to something else because I am almost positive it at least contributed to my rapid weight gain. Like others said, I am also tired all day every day. Very little energy. I haven't gotten a period since a month or two after I started taking it. Not worth it though.”

1 / 10
Anonxxx August 23, 2016

Depo-Provera (medroxyprogesterone): “Got recommended by the surgeon that did my laparoscopy to try Depo out after severe pain and bleeding being bed bound for atleast 4 days every month and suffering daily from the endo and interstitial cystitis which I have alongside. It has been a god send for me, it does take a toll with mood swings and energy but I think the conditions contribute to that themselves also! I have probably 10 days tops every 3 months before the shot is due that I'll get very bloated (a good 4/5lbs worth on the scales!!) and feel sicky and not right with spotting but as soon as I have the shot again all gone! I'm happy with feeling a bit rubbish once every three months with much less pain rather than every couple of weeks doubled over!! Thank god for depo!!!”

9 / 10
Ckw56 · Taken for 6 months to 1 year May 6, 2016

Depo-Provera (medroxyprogesterone): “I have been on MANY birth control pills and hardly any of them were beneficial to me. I switched to this injection and I'm so happy I did. I started birth control when I was 15 bc my cramps were unbearable. Endometriosis runs in the fam. I also had bad acne so I was trying to alleviate both of those issues. The depo shot didn't affect my acne in any way but it has almost completely diminished my cramps. The first 3 months were rough. didn't bleed for a month and 1/2 after getting it, but then I bled until it was time for my next shot. I got my second shot and didn't have my period for three months. It was AWESOME. Spotting around the due date for next shot is normal. Oh and the shots are painless. Stick through the rough first months!”

9 / 10
Moody24 · Taken for 1 to 6 months April 19, 2016

Depo-Provera (medroxyprogesterone): “I've had a horrible experience with this shot. I only wish I have read all of the horror reviews before getting it to save myself a year of hormonal problems and a scarred face from a cystic acne breakout. Once I got the shot I got online and started reading the reviews and was horrified because part of me knew I made a huge mistake- and oh did I. I bled for 6 months straight! I was practically drinking liquid iron by glasses because of how much blood I was losing after getting the shot. I got the shot BECAUSE of painful and heavy bleeding periods! But it only made it much much worse. I finally went back to my docs, they put me on patch that stopped the bleeding”

1 / 10
Ellis maye March 1, 2016

Depo-Provera (medroxyprogesterone): “Was on depo shot for 9 months. First I had lighter periods and the endometriosis pain was better. Second month I had light period but it was all month. And then after that the pain was less and there was no bleeding. I started to gain weight. Almost 50 pounds. I already have back pain from herniated disk so I did not go and get my last shot. Endometriosis pain is back ten times worse. And I have been bleeding almost nonstop since September 2015 and it is now March 1 2016. I'm gonna go back to the Dr and have a hysterectomy. I can not stand the bleeding or the pain”

1 / 10
Tae-Tae December 9, 2015

Depo-Provera (medroxyprogesterone): “I have was dx with endometrosis back in 2010. I have had 4 chest tubes surgeries within 3 years. I was also dx with catamenial puemothorax which you can google to get more info about but it has a lot to do with my period etc it all goes together. But I have been on birth control pills, lupron and now on the depo. And I must say the only think that helps was the lupron , besides of the side effects of hot flashes, cold sweats etc. But the pill was a no go. I didn't like how it made me feel and I have been on the depo shots for a few months but I must say it worked in the 1st few months but now i have been bleeding for he last 4 months nonstop and I am just stop everything cause I'm so over with trying different things - its so frustrating.”

5 / 10
HML1226 · Taken for 1 to 6 months December 7, 2015

Depo-Provera (medroxyprogesterone): “I was recently put on depo provera as a last-ditch effort prior to undergoing a full hysterectomy to relieve serious pain from endometriosis. While it has been effective for relieving the pain, I have been heavily spotting or more for over 2 months now... every day. I decided not to get another shot and I am now experiencing random horrible stabbing pains in my ovary (not like the endometriosis pain). Pain aside... 2 months of feeling too gross to have sex - I feel bad for my husband! I was on depo for years during my younger years and never had any issues. I stopped taking it because I thought I was going to be able to have children; that turned out to not be the case, so I thought it couldn't hurt to try it again... bad choice!”

2 / 10
Rocky birds December 2, 2015

Depo-Provera (medroxyprogesterone): “Do not get this shot! It tried to ruin my life. Heavy sporadic bleeding, mood swings, depression, headaches, body aches, NO sex drive, terrible cramps, I have little/no emotion for almost everything. I only had 2 shots. I just want to get back to my normal :(”

2 / 10
OodlesOPoodles November 30, 2015

“I took this medication two years ago and only received three shots before having to quit due to migraines. It thinned my hair, my bones, made me a raging lunatic. I still suffer from migraines. This drug did NOTHING to stop my endo. While on it, I needed to have 3 lapex surgeries and was always on Vicodin or Percocet for pain. If your doctor says to try this medication, I would RUN not walk to the nearest exit and go get a second opinion.”

1 / 10
kateeee1704 · Taken for 1 to 2 years November 17, 2015

Depo-Provera (medroxyprogesterone): “I've been on depo for almost two years now and have not had a period since i got the injection. i no longer have the debilitating cramps that i would get each month which is a godsend. after i'm first given the shot, i have about 5-7 days of being a little more emotional than usual but it's usually due to my hormones being balanced and changing a little, but it just means a bit of crying and basically how i used to be emotionally before a period. i have noticed that some nights i wake up with a really extreme cramp out of nowhere, but i believe that that might be an issue that's more to due with my hormone levels etc. either way, depo has definitely spared me from weeks spent in bed because of the painful cramps!”

9 / 10

Learn more about Endometriosis

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Symptoms and treatments

Mayo Clinic Reference

ICD-10 CM Clinical Codes (External)