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User Reviews for depo-subQ provera 104

depo-subQ provera 104 has an average rating of 6.0 out of 10 from a total of 30 ratings on Drugs.com. 45% of reviewers reported a positive experience, while 39% reported a negative experience.

Condition Avg. Rating Reviews Compare
Birth Control  
4.5
15 reviews 341 medications
Endometriosis  
7.6
15 reviews 101 medications
Summary of depo-subQ provera 104 reviews 6.0 30 reviews

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Reviews for depo-subQ provera 104

clarissa ann · January 10, 2013

For Endometriosis: “I got on this as a teenager for my endometriosis. Besides spotting for the first four months I have had no ill effects. No weight gain. In fact its hard to keep weight on. I got off of it to have my kids. Now I'm back on it. It's so much easier raising toddlers without cramps and random bleeding. I recommend it highly. Don't let bad experiences scare you. I actually had a horrible time with the pill. I love my Depo shots!”

10 / 10
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TN mom · March 5, 2014

For Endometriosis: “I was hesitant to try this but I really didn't want to have a hysterectomy. I've already had one ovary/tube out due to my endometriosis. I was recently diagnosed with also have adenomyosis now. It was Depo-subQ, Lupron or a hysterectomy. I read so many terrible reviews that it had me nervous but I tried it anyway. I've gained a few pounds but am also 45 and lazy so that may be the more likely culprit. My acne is actually gone. I've had no endometriosis symptoms. My hair is slightly thicker. For me it's been a miracle. We're hoping to be able to have these results until menopause hits.”

9 / 10
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nkb · Taken for 1 to 2 years · February 8, 2014

For Endometriosis: “My doctor put my on Depo-Provera after laproscopy for endometriosis. I had irregular periods after the first shot and after the second I remember I had one period that seemed to last for a month. This is a known side effect and as promised it went away after the third shot. I haven't had my period now in about a year. I also haven't had any debilitating endometriosis symptoms either. I think I gained about 5 lbs total but then again I'm also in my 40s and that could simply be a part of aging. I am a big fan. It gave me nearly total relief after getting through the first 6 months.”

9 / 10
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missbones · Taken for 1 to 6 months · January 12, 2014

For Endometriosis: “I have severe endometriosis and a lot of scar tissue from laparoscopic surgery four years ago when they removed two large cysts that were wrapped around my fallopian tube, which I lost. Then last year my right ovary hemorrhaged and I bled internally for two days, two weeks ago I had a cyst rupture on my ride side. I am SO done with being in pain. I've been in non stop monthly HELL for the past 4 years! So I got back on the Depo-Provera shot. I took it when I was a teenager for two years for my endo pain. And I loved it. I am so glad to be back on it. I am also on a seizure medicine that makes birth control ineffective, but has no effect on the Depo shot, so that is another plus.”

10 / 10
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Emmamp · Taken for 1 to 2 years · January 23, 2019

For Endometriosis: “I have been on this for almost 2 years now, it was working great no side effects and also keeping my endometriosis under control (the main reason it’s all I can use). Suddenly I started having large gushes of blood while not on a period with the depo-subQ provera . I would spot for a few days then stop then a large gush, heavy enough to bleed through my oversize pad and my clothing. I have had many ultra sounds, MRI, and still no answer to why this started after being on it for so long. If anyone else has experienced that I would love to know if you have found a cure. I need the depo to help my endometriosis so unfortunately I can’t use any other form of birth control.”

7 / 10
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Judii47 · March 6, 2015

For Endometriosis: “I've had endometriosis my whole life... Six surgeries.. I was on Lupron 2x.... Birth control pills.... Finally the depo was my last resort.... The first time it made me bleed everyday for 7 months... I didn't give up on it... It made me gain weight because it increases your appetite and u don't realize it until u go off of it.... I still didn't give up... I've been on it now for 5 years and I have joined weight watchers and increased excercise..... I have not had a period in 5 years..... I don't miss the agony ... The pain... The hospital visits.... Being bed ridden for 3 days a month.... I love the Depo...and now I'm making progress with losing weight so I'm happy...”

10 / 10
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Cytogirl · Taken for less than 1 month · June 6, 2014

For Endometriosis: “I refused to get the shot because I had researched Depo for a paper in college, but it came down to Depo or severe anemia. So I received the shot and the next morning I was praising Jesus because the shot got rid of the almost constant back pain I'd had for 2 years since delivering my twins. Doctors kept telling me it was a sprained muscle only it never healed, now I believe it was endometriosis.”

10 / 10
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Frequently asked questions

Ckw56 · Taken for 6 months to 1 year · May 6, 2016

For Endometriosis: “I have been on MANY birth control pills and hardly any of them were beneficial to me. I switched to this injection and I'm so happy I did. I started birth control when I was 15 bc my cramps were unbearable. Endometriosis runs in the fam. I also had bad acne so I was trying to alleviate both of those issues. The depo shot didn't affect my acne in any way but it has almost completely diminished my cramps. The first 3 months were rough. didn't bleed for a month and 1/2 after getting it, but then I bled until it was time for my next shot. I got my second shot and didn't have my period for three months. It was AWESOME. Spotting around the due date for next shot is normal. Oh and the shots are painless. Stick through the rough first months!”

9 / 10
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Niki · Taken for 6 months to 1 year · August 1, 2020

For Endometriosis: “I have been having the depo injection as I have endometriosis. It has worked wonders for me, after the first 2 injections I was spotting a lot, but after the third it stopped my periods completely- which were so heavy and painful. The only down sides are when I first get the injection I am really grumpy for the first few weeks. My sex drive is no where near as high as it used to be and I have gained weight, which the doctors tell you will only happen if you eat more. I find this not to be true, I have been exercising more than I ever have and eat so healthy all of the time. No matter what I am doing I can’t seem to loose the weight.”

8 / 10
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Anonymous · September 26, 2011

For Endometriosis: “I've only taken one shot, it has been somewhat of a last ditch effort to provide some pain relief from endometriosis and polycystic ovaries. The first month was great, no pain and very little spotting. The second month has been horrible, I had a period for 2 1/2 weeks and the other 1 1/2 I had spotting along with horrible (at times) pain that even Lortab won't fully control. Doctor gave me estrogen to stop bleeding and that took a week. As of now I am not taking another shot. I told my husband that I can feel this bad for free. If this third month goes okay I may reconsider. I've tried everything and its bad...looks like hysterectomy is next step.”

1 / 10
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Anonymous · October 1, 2011

For Endometriosis: “I've had endometriosis for over 20 years and have had about enough of the pain and the accompanying anemia from blood loss. In the last 5 years my blood loss from the endometriosis has increased tenfold and I have developed severe iron deficiency anemia. My OB/GYN and I decided to try Depo again (last time was in the early 90s) and I had my first shot in July of 2011. August was HEAVEN! No period and my iron levels tested almost normal. I was human again! Now it's September and I have had a "period" (in quotes, because it's more like a normal woman's period) for over 15 days and I feel like I have been hit by a Mac truck. No endometriosis pain, but my iron levels are so low from bleeding that all I can do is sleep. When it works, it's fantastic.”

8 / 10
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Ellis maye · March 1, 2016

For Endometriosis: “Was on depo shot for 9 months. First I had lighter periods and the endometriosis pain was better. Second month I had light period but it was all month. And then after that the pain was less and there was no bleeding. I started to gain weight. Almost 50 pounds. I already have back pain from herniated disk so I did not go and get my last shot. Endometriosis pain is back ten times worse. And I have been bleeding almost nonstop since September 2015 and it is now March 1 2016. I'm gonna go back to the Dr and have a hysterectomy. I can not stand the bleeding or the pain”

1 / 10
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n1723 · April 9, 2015

For Endometriosis: “I was diagnosed with stage 4 endometriosis at 17 years old. After being on Lupron for 6 months, my doctor proceeded to put me on Depo for the rest of my life until I decide to have kids, and then back on the shot afterwards. I am now on my 5th shot and I've had horrible endometriosis pain(not cramps, very different pain) and have had my period for 2 weeks. I am not sure the Depo is working correctly with my body but other than that, the previous shots have made almost all pain from my endometriosis go away.”

7 / 10
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Megaphone1220 · April 5, 2015

For Endometriosis: “I started my first injection over a month ago for my severe endometriosis. The day after I started noticing terrible mood swings, as did my family. I would get angry and freak out at the tiniest things. Usually cry over nothing. It lasted for about 4 weeks and my moods have simmered down, but not as much as they should. He said to consider Zoloft, because my hormone levels aren't normal and I have anxiety. I have been spotting everyday for the whole month, and still notice some pain, but not as bad as it was before I started the injections. My obg said this was normal, and assured me after the third injection this would go away. Hopefully it does. I can now say I'm not living in hell 12 times a year.”

7 / 10
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Shell7seas · Taken for 2 to 5 years · August 27, 2015

For Endometriosis: “I started on the shot in 2013 to help with the pain from endometriosis my cycle was pretty regular but I was in constant pain. The first year went pretty good with no side effects after the first year I started bleeding heavily and continued to for three months I was put on estrogen and the depot shot went from every twelve weeks to ten weeks after three months of this I under went a uterine ablation the bleeding stopped but the pain from the endometriosis is still an every day problem and I have put on 45lbs my blood pressure has went up. My doctor and I have decided the depot shot is no longer an option. the shot worked I suggest monitoring your health while on it.”

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Mesia · Taken for 2 to 5 years · December 11, 2019

For Abnormal Uterine Bleeding: “I don't know what to do anymore because I'm staying with my husband 24/7, we can't have sex because I'm bleeding nonstop. It has been 3 months now I would like to know if there is something I can do to stop it”

1 / 10
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AnonMD · April 17, 2014

For Birth Control: “Just recently have got Depo subQ provera for the first time--(at the same time my best friend has gotten the regular Depo-Provera shot)--I haven't had any side effects: no mood swings, no weight gaining, nothing. While she's had some mood swings going on. I don't know if it's because it's a different Depo or just because I'm a different person, but I'd recommend this to people. Plus it's a much smaller needle that goes in your stomach instead of your arm.”

10 / 10
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dawn19825 · Taken for 1 to 6 months · March 11, 2018

For Birth Control: “DON'T get this shot, because if it hurts your body. It's's not like you can stop taking this drug. It causes a wide array of problems, and you don't know if they will effect you until you get the shot. I have had pretty good experiences with changing birth control before, and had no abnormal bleeding, no painful periods, no nothing, so I thought it would be OK. Literally the day I got the shot, I started my period again (it had just ended, too) and I didn't stop bleeding for 90 days. For the entire 3 months my entire uterus and vaginal opening was in complete agony. I couldn't stand being touched, and my husband got really angsty. I had the worst cramps of my life, too. The DAY the shot wore off, everything was better.”

1 / 10
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Anonymous · September 8, 2011

For Birth Control: “I highly recommend depo-subQ provera 104. I was on it for a little over 2 years (which is not recommended). I didn't have a period, which I loved, and I only had to go in and get it every three months, which was also very nice. The only reason I stopped Depo was in order to try and get pregnant. Once I am done having kids/take a break from having kids, I will definitely go back to Depo. I also didn't have many side effects from Depo, just breakthrough bleeding some months.”

10 / 10
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Reshma · Taken for 1 to 6 months · December 7, 2019

“Hello everyone. Please never go for the depo-subQ provera 104. I've been bleeding since I stopped my first depo. I feel like I've been bleeding since forever. I know my husband isn't happy with that since we cannot have sex like before but then he is very much understanding. Thank goodness. But I wonder when is the bleeding going to stop. Unaccountable number of pads, I am so sick and I feel frustrated.... Doctor prescribed me with some pills. It works but next period again is the same. I don't want to take pills over and again.. What am I going to do. How am I going to make it stop. I am so sick of it... Tired... Frustrated.....angry....”

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Crys1922 · June 25, 2016

For Birth Control: “Never use this shot it makes your discharge thick and white after it wears off. You don't have a period for 2 years and it throws off the pH causing BV and frequent yeast infections also get a lot of head aches and low sex drive”

1 / 10
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Kelllllc · February 20, 2018

For Birth Control: “Worst decision I ever made! I gained weight and bloated sooo bad even when I didn’t eat I bloated! I stopped taking it and I am still trying hard to lose the weight. I have always been petite but now I look pregnant because I am so bloated! I had no period which was nice but had no sex drive. It works for my friend but for me I hated it!!!”

1 / 10
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Hate it · Taken for 1 to 6 months · November 2, 2016

For Birth Control: “I took the depo-subQ provera 104 shot twice, one shot every 3 months, right after high school. While I did not get pregnant i gained 50 pounds. I had always been a tiny person. I was 100 pounds when I graduated and after that 6 months I was 150. No change in diet and I was actually more active. AFTER I decided to get off of it I was unable to lose the weight and I didn't get my period for 9 months and was not able to get pregnant for a year and 9 months, which actually was failed (blighted ovum) and I finally am pregnant 2 and a half years later. All from 2 shots. My whole life I had very regular light periods. After the shot they were random and fluctuated in flow from heavy to only spotting. I would never recommend this birth control.”

4 / 10
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Dee · October 23, 2019

“I took this crappy depo-subQ provera 104 after I miscarried my son in 2004. They gave me the Depo in February 2004 and I didn't stop bleeding until September! Every time I thought it was going away.....BOOM I'm bleeding heavy all over again to the point that my iron became low it was way too much bleeding. 7 months SMH and I see it hasn't changed years later”

1 / 10
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Non · Taken for 10 years or more · July 26, 2019

For Birth Control: “I had the depo injection after my youngest daughter was born - she is now 25 - I have not had a period since - not gained weight - best thing I ever did - only thing now is I don’t know if I have been through menopause as I am now 49 - I asked if it was okay to not have any period or spotting but docs do not really have an answer - can only have it until I’m 50”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.