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depo-subQ provera 104 and Spotting: What Users Say

Spotting: mentioned by 7 users (20.0%)

Based on user experiences from 35 depo-subQ provera 104 reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

bleeding 31.4%
weight gain 31.4%
spotting 20.0%
cramps 11.4%
mood swings 11.4%
sexual dysfunction 11.4%
irregular periods 8.6%

Reviews for depo-subQ provera 104

Commonly mentioned side effects
  • cla...
  • January 10, 2013

For Endometriosis "I got on this as a teenager for my endometriosis. Besides spotting for the first four months, I have had no ill effects. No weight gain. In fact, it's hard to keep weight on. I got off of it to have my kids. Now I'm back on it. It's so much easier raising toddlers without cramps and random bleeding. I recommend it highly. Don't let bad experiences scare you. I actually had a horrible time with the pill. I love my Depo shots!"

10 / 10
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  • Ckw...
  • Taken for 6 months to 1 year
  • May 6, 2016

For Endometriosis "I have been on many birth control pills and hardly any of them were beneficial to me. I switched to this injection and I'm so happy I did. I started birth control when I was 15 bc my cramps were unbearable. Endometriosis runs in the fam. I also had bad acne, so I was trying to alleviate both of those issues. The depo shot didn't affect my acne in any way, but it has almost completely diminished my cramps. The first 3 months were rough. didn't bleed for a month and a half after getting it, but then I bled until it was time for my next shot. I got my second shot and didn't have my period for three months. It was awesome. Spotting around the due date for the next shot is normal. Oh, and the shots are painless. Stick through the rough first months!"

9 / 10
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19 Report
  • Anonymous
  • September 26, 2011

For Endometriosis "I've only taken one shot, it has been somewhat of a last-ditch effort to provide some pain relief from endometriosis and polycystic ovaries. The first month was great, no pain and very little spotting. The second month has been horrible, I had a period for 2 1/2 weeks, and the other 1 1/2 I had spotting along with horrible (at times) pain that even Lortab won't fully control. The doctor gave me estrogen to stop bleeding, and that took a week. As of now, I am not taking another shot. I told my husband that I can feel this bad for free. If this third month goes okay, I may reconsider. I've tried everything, and it's bad... looks like hysterectomy is the next step."

1 / 10
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19 Report

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Frequently asked questions

  • Meg...
  • April 5, 2015

For Endometriosis "I started my first injection over a month ago for my severe endometriosis. The day after, I started noticing terrible mood swings, as did my family. I would get angry and freak out at the tiniest things. Usually cry over nothing. It lasted for about 4 weeks, and my moods have simmered down, but not as much as they should. He said to consider Zoloft because my hormone levels aren't normal, and I have anxiety. I have been spotting every day for the whole month and still notice some pain, but not as bad as it was before I started the injections. My ob-gyn said this was normal and assured me after the third injection this would go away. Hopefully, it does. I can now say I'm not living in hell 12 times a year."

7 / 10
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  • Hat...
  • Taken for 1 to 6 months
  • November 2, 2016

For Birth Control "I took the depo-subQ Provera 104 shot twice, one shot every 3 months, right after high school. While I did not get pregnant, I gained 50 pounds. I had always been a tiny person. I was 100 pounds when I graduated, and after that 6 months, I was 150. No change in diet, and I was actually more active. After I decided to get off of it, I was unable to lose the weight, and I didn't get my period for 9 months and was not able to get pregnant for a year and 9 months, which actually was failed (blighted ovum), and I finally am pregnant 2 and a half years later. All from 2 shots. My whole life, I had very regular, light periods. After the shot, they were random and fluctuated in flow from heavy to only spotting. I would never recommend this birth control."

4 / 10
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  • Emm...
  • January 18, 2018

For Birth Control "I loved it. I was on it a little over 2 years and have just stopped at the suggestion of the doctor due to the bone loss. I am struggling to find another birth control that could ever be as good for me personally as this one. I didn't have a period unless I was in my window for another shot (every 3 months). There were times where there was light spotting, but nothing bothersome. No cramps, mood swings, and no weight gain that I can tie to it. I hope I can find another that works so well with my body."

10 / 10
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  • nev...
  • Taken for 1 to 6 months
  • February 25, 2023

For Birth Control "I have had two shots and, 5 months in, have had spotting every single day. I have also had UTIs, probably from the hormone flux. I won't be taking it again."

2 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.