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User Reviews for Synthroid to treat Underactive Thyroid

Synthroid has an average rating of 6.2 out of 10 from a total of 75 ratings for the treatment of Underactive Thyroid. 53% of users who reviewed this medication reported a positive effect, while 35% reported a negative effect.

Synthroid Rating Summary

6.2/10 average rating

75 ratings from 86 user reviews.

Compare all 54 medications used in the treatment of Underactive Thyroid.

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Reviews for Synthroid

Wonttakesynthroid · Taken for 10 years or more February 16, 2019

“I was on Synthroid for 10 years. I was in so much pain in my joints, I couldn't function. This is a known side effect of this medicine. My numbers were where they were supposed to be per the doctors, but I still felt tired and my hair was still falling out. After my husband and I did research, we worked with my doctor and switched to Armour Thyroid. Within 6 weeks my pain was gone, I felt better. I wasn't tired and my hair was falling out. No matter what medicine you use - you know how you should feel. Do the research and work with your doctor. Only you know how you should feel. Don't depend on the doctor to tell you.”

1 / 10
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Robert2013 March 11, 2013

“Synthroid saved my life....been taking it for almost four years now. I had all of the worst symptoms in the worst way of a basically dead thyroid. I was feeling better within a week of taking it and continued to feel better and better every day for about the next six months. That's when it leveled off and I've been happy (and grateful) ever since. It took about a year or so to lose all of the weight I gained as a result of crummy thyroid. The weight just came right off after taking Synthroid. I'm on 225Mcg per day with very minimal side effects...so minimal that I can't recall what they are at the moment.”

10 / 10
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sharonc2006 · Taken for 10 years or more January 19, 2014

“Reading all the posts/comments on here - PEOPLE - if you are still feeling bad and not noticing relief from symptoms of an underactive thryoid PLEASE TELL YOUR doctor. If your doctor disagrees with you then find an ENDOCRINOLOGIST to get a second opinion. They specialize in endocrine issues which the thyroid falls under. You know your own body better than your doctor - research the symptoms of an underactive thryoid and if you are still feeling them - then get a second opinion. Never stop taking this medication on your own, it takes 4 to 6 And be aware that when you start this m weeks to notice a difference in your body. Also, ask your doctor to write DISPENSE AS WRITTEN on your prescription to avoid the pharmacy giving generic”

10 / 10
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laura April 24, 2021

“Amazing!! I started on 25 mcg brand Synthroid then 50 mcg and now I'm on 75 mcg I almost feel like the old me my TSH went from 11 to 1.7 I wake up 4 am take my medicine and go back to sleep till my 6am alarm I have a cup of coffee when I get up to start my day.”

10 / 10
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Anonymous · Taken for less than 1 month March 17, 2013

“Only been on this medicine for 4 days and it has already made a huge difference in how I feel. The depression was awful and the intolerance to the cold was bone chilling. I hope things continue to look up. So far so good!”

10 / 10
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Retazlaw · Taken for 1 to 6 months January 21, 2019

“To be honest I'm not a person who has ever taken medications. So when my physician told me I had a under active thyroid I didn't really know what to think because I didn't feel as though I had any of the common symptoms. I just thought the symptoms the doctor mentioned were just normal ageing since I am 55 years old. I have been taking this medication now for a little over 4 months and have started to see some noticeable changes. 1) my hair stopped falling out. 2) nails started growing faster and stronger. 3) All around much more energy. 4) Able to focus better. So far I have been very happy with the results. I cannot give this a total 10 because everything has room for improvement.”

9 / 10
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ccgv6 October 23, 2016

“I was falling a sleep every time I sat down - even at the computer, rocking a baby, in a car ride. I was trying to lose weight, but gaining instead. Someone would touch me and I would start sweating. I am 58. I have been on Synthroid (not generic) for 6 days now. I too am feeling a whole lot better. I was at 202 lbs 10 days ago. Today I am at 187.6 lbs. I did fall a sleep at the computer again last night, but my energy level is coming back.”

8 / 10
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Frequently asked questions

John jacob July 9, 2016

“I can almost guarantee that most of these negative reviews are due to either 1. Taking the medication incorrectly (generic works for some not all), too close to food or iron,calcium, some antidepressants interfere) 2. Taking the incorrect dose 3. Not being consistent(must be close to the same time daily ) I had gone through many changes before finally getting it right. Seems to be working good after getting on brand name and taking it seriously.”

9 / 10
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Jaybee63 May 24, 2017

“I have been on synthroid for approx 10 years. Here are several points that I have learned: 1. You may initially start feeling better in a couple weeks but It takes MONTHS to see the full effects. 2. Depending on your TSH levels, your Dr should start you at a low dosage and gradually increase as needed. Starting with too high of a dosage is shock to your body and will even make you feel more tired as your body is working overtime. 3. See a Physician who is very familiar with thyroid issues. If you are not seeing positive results with family Dr. see an Endocrinologist! Many of the negative comments I have read may be a result of your Dr not understanding this disorder. 4. There are alternatives if this medicine is not working.”

6 / 10
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Hyper by Nature · Taken for 10 years or more November 23, 2019

“I am a 57 year old women who has hypothyroidism been taking 100mcg of synthroid for 10yrs I dread taking this pill every morning I feel like I have a out of body experience blood rushes to your brain and the anxiety hair loss now experience muscle and joint pains itch all over brain fog insomnia. For the past week I have been cutting it in half I will be stopping this crazy cycle I have lost so much weight just from the anxiety and insomnia I do not want to have to live off a synthetic pill and Klonopin and be told I am depressed I feel better without it”

4 / 10
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Vinayyyyy070709 March 16, 2016

“I just started this medicine about a month ago. It is making such a big difference in my appetite and my energy. I am a fairly young man at 23 years old. I knew something wasn't right with my body over the last few years, as I had gained about 30 pounds over the course of just a few months and felt so sluggish. It turns out, like many of you reading this, I have an underactive thyroid. I have heard that three drugs help with the thyroid hormones. Synthroid (T4 hormone), Cytomel (T3 hormone), and Armour Thyroid (T4 & T3 Hormones). Synthroid has gotten a bad rap because it's synthetic and it only covers the T4. Well, the T4 is most likely all you need because a T3 deficiency is rare. Synthroid is great. Stomach upset went away in 1-2 weeks.”

9 / 10
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Marbunk June 17, 2021

“I have taken Synthroid (branded) since 2005 (dose .075) with no issues or side effects, have kept annual notes on TSH t3 t4 test results since that date. Recently, my TSH dropped to .25 with t3 and t4 in normal range. Doc switched me to .50 from .075 because my TSH was low. The side effects were absolutely awful for 5 weeks with the worst being muscular pain throughout my whole body afraid my legs would give out. I stopped taking after 5 weeks for 2 days while waiting to see Doc to see whats happening. Within 1.5 days, the symptoms relieved without any pain medication. I believe there is some change to the drug and have contacted Abbvie (waiting for an answer) to see if the fillers (which are numerous) have been changed from 1 dosage to another. If you are having any side effects, you must call them and report it, especially if they are long term or severe as mine were. I am back on .075 with no issues...... something is wrong here. Will keep posted.”

1 / 10
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Spudth November 13, 2019

“Mine is a long story. I began taking synthroid in 1993 after a required dr visit. All I can say is WOW! It was not a sudden boost but a lifetime of feeling listless and tired was gone. I have been on the medication now for about 22 years. If I miss a dose, generally doesn't feel bad. Miss it for several days and I start getting tired etc. Can't imagine being without it. Certainly changed my life. Didn't do it overnight but it sure did take away that sleepy feeling. In 1997 the doctor told me it was known to be uncommon for men to have thyroid issues. Well, I think thats because men aren't tested as much. Now in 2019 I believe the treatment rate for men is probably just below that for women. Good deal. Never had a real bad experience. Not sure though where the meds come from and the whole concept of changing brands. I'm sloppy in taking it as I do it in the morning then drink coffee and often can eat breakfast right away as well. Good Luck to all.”

10 / 10
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Tramag823 · Taken for 1 to 6 months July 3, 2013

“I started taking Synthroid about 6 months ago and I feel really good. I went from feeling like a zombie to feeling like my normal self again. Before starting on Synthroid I had most of the typical hypothyroid symptoms...tiredness, dry skin, cold intolerance, puffy face, etc. Now the only symptom that still bothers me is water retention. My Dr. just increased my dose so hopefully that goes away soon.”

10 / 10
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Pebbles · Taken for 5 to 10 years October 25, 2019

“I do not notice any difference with the medicine, I’m still suffering from depression and I have extreme hair loss and weight gain even if I don’t eat more than 1500 calories a day. High protein, low carbs”

1 / 10
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Annette · Taken for 2 to 5 years May 2, 2018

“I was taking Synthroid for three years. I was extremely ill during that time and it worsened. I could not eat, walk without falling, gained 30 pounds and my numbers did not go down. Finally my endocrinologist agreed to put me on Armour Thyroid medication. I lost all the weight I had gained in two weeks, could eat and walk. My whole life changed dramatically. Doctors are giving Armour a bad name, but I can tell you from my experience, it changed my life.”

1 / 10
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CatB · Taken for 10 years or more November 27, 2020

“I have been on Synthroid since 1993. Prior to starting it, I couldn't lose weight no matter what I did. It was and is the help I needed. After being on Synthroid for about a decade, my insurance requested I switch to a generic. After a couple of months, my TSH levels were no longer balanced and my dose was increased. After nearly a year of no control, no matter what dose I was on, my levels and symptoms wouldn't stabilize. My doctor and I realized the change happened when I was switched to the generic. It took several months back on the Synthroid before I was stable again. No more generics for me, now it's my wallet getting lighter because of how expensive it is. But at least my levels are stable.”

10 / 10
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Tia4life August 22, 2013

“Although Synthroid keeps my test results "normal" I still have all of the hypothyroid symptoms. Severe exhaustion, sensitivity to cold, trouble concentrating, etc...like I haven't experienced since before I found out I had hypothyroidism. I was only put on Synthroid since the medication I am normally prescribed is no longer available.”

3 / 10
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gfmissouri · Taken for 10 years or more February 2, 2013

“I have been taking this medication for almost 22yrs. My thyroid is dead the Dr. said due to child birth. I started out on the lowest dosage. Dr. didn't want to shock my body I had to cut them in half for 2 weeks and then slowly went up from there. I am now taking 200mg now have been for several yrs now. Medication works good for me. If I miss a day I can tell and I feel really tired.”

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irene2004 October 27, 2011

“I have been on synthroid for about 7 years. I am 43 now. I still feel very tired, I have no energy. No motivation. My bones feel weak. I have been telling my doctor maybe I need a higher dosage. He said no. I told him maybe I need to change it he said no I'm fine but I know my body. My hair is falling, it's thin. Maybe a new doctor can help me.”

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Less Than Human September 11, 2011

“Been on this medicine about 9 months after discovering my thyroid was starting to malfunction. I have had no weight gain or mood changes, and not a problem to speak of. My hair stopped falling out so much, it started growing like crazy along with my nails. I know I metabolize food more quickly, I will spare you the details. My skin isn't as dry, and I have been having an easier time with my mood in combination with other medications.”

10 / 10
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Anonymous February 27, 2008

“If you boil up balsom tea every day for one month you will cut your colestral and your thyroid down to where you dont have to take drugs. Its no quick fix but its a lot better than taking drugs. My wife is going off a lot of drugs and feels a lot better.”

1 / 10
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bbynekomata · Taken for less than 1 month November 14, 2016

“I was just diagnosed with hypothyroidism on the last days of October of this year.. My doctor prescribed me 50mcg levothyroxine distributed by Mylan. I was only on the medication for 3 days! The medicine made me so fatigued and tired I could hardly go through my day without wanting to pass out and go to sleep. And not only that but my chest was feeling really uncomfortable. It felt like someone had put 20 pounds on my chest and overall having difficulty taking a deep breathe. My doctor then prescribed me the brand name Synthroid with only 25mcg. I had energy like I havent had in a year, but on the third day i was having shortness of breath, my heart was beating so hard& fast &I felt so lightheaded. Seriously, scariest experience i have had.”

3 / 10
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Kimroid · Taken for 1 to 6 months July 6, 2021

“I have been taking random dosage of levothyroxine for 1 year now and my endocrinologist and I still haven’t found my perfect dose. I switched over to synthroid at 125 MCG and I’ve been on it for about 2 weeks now. I know it takes about 4-6 weeks to hit its peek. But I am just so impatient and tired of it not being my proper dose. I’m 27yrs and my left eyebrow hairs started to turn white and by bottom lashes are all white and now my top lashes are starting to turn white too. It’s very concerning I was told it’s from my autoimmune disorder. Is anyone else going through this?”

1 / 10
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sd21 · Taken for less than 1 month March 4, 2015

“I began taking my Synthroid three weeks ago and I feel great. First I began breaking my 25 mcg pills into quarters and started out taking only a 1/4 pill. I do this in the morning with a glass of water. I am now taking one 25 mcg pill. My sleeping has improved, I have more energy, my skin looks better and my face does not look tired,. I refused to take this drug initially when I was first diagnosed in 2011 because of a bad scare taking the generic brand, so I let my new meds sit for six months before trying this brand. It works wonders for me and being a life-long gym and karate guy, I have more energy to do laps in the pool and do weights too. I have taken iodine and it works ok, but nothing like my Synthroid. Time will tell.”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.