Goserelin and Fatigue: What Users Say

• Wig...
• Taken for 6 months to 1 year
• June 15, 2016

For Endometriosis "Brittle nails, hair loss, severe depression, memory problems, difficulty concentrating, skin rash, hot flushes, sleepless nights, short temperament, intolerance to alcohol, joint pains, nausea, fatigue, IBS, low libido, painful sex... This drug compromised my mental well-being for a few months of pain relief, it cost me my relationship and almost my job, not worth it at all!"

• Wit...
• February 15, 2016

For Prostate Cancer "My partner has been on and off Zoladex for nearly 6 years, with PSA first detected at 4000 and soaring between 0 - 600 - 50, but with 12-month breaks in treatment. He takes a regime of ganoderma mushroom extract, he believes this has also helped him stay very healthy and free of cancer symptoms. The only side effects and illness he suffers is from Zoladex. It probably has contributed to saving his life, but it has changed that life forever. He has huge mood swings, confusion, memory loss, fatigue, total loss of sexual function. In short, it keeps him alive but keeps him alive and completely altered. If you have low testosterone levels, then the side effects are mild. If you have high levels, it is personality changing."

• kik...
• March 1, 2010

For Breast Cancer, Palliative "I am 32 years old, and I have to take Zoladex for 3 years with the medicine Tamoxifen for 5 years. I have been on Zoladex for about a year now. Some of my side effects include severe mood swings, hot flashes, loss of menstrual cycle, weight gain (28 pounds so far), loss of energy, swelling of hands, and forgetfulness."

• Pet...
• May 28, 2012

For Endometriosis "I've been on Zoladex for 8 months now, I'm just having my 9th injection this week. Positive effects: endometriosis is not inflamed anymore, which increases chances of getting pregnant. No periods, therefore no pain. Side effects: where do I start? The worst is significant weight gain, tiredness, hot flushes, sleepless nights, and low energy levels. Plus, no sex drive whatsoever. But anything to have a baby."

• Ska...
• Taken for 1 to 6 months
• September 3, 2019

For Endometriosis "I’m on my 5th out of 6 monthly implants and am unlikely to be swayed to go on Zoladex again, as the side effects - particularly severe joint pain, extreme mood drops, and chronic fatigue - are more difficult for me to cope with than the endo. I had a recent diagnosis of Stage 4 endometriosis and adenomyosis, so the Zoladex implants were prescribed by a leading surgeon after he performed successful excision surgery and removed the left ovary. The Zoladex is used in conjunction with a Mirena. Within the first month of treatment, I was having hot flushes and consistent low-grade headaches, so then was also prescribed Livial to deal with those side effects. I was being treated for anxiety and depression before the Zoladex, but my psychiatrist doubled the dose of Citalopram to 40mg about three months in to deal with the sudden mood drops. I feel like I’ve been hurdling into menopause and am aging rapidly beyond my 42 years."

• Lev...
• Taken for 1 to 6 months
• October 23, 2019

For Endometriosis "On my 3rd and final monthly injection of Zoladex for endometriosis. Suffered from mild headaches, very frequent hot flushes, fatigue, low libido, and feeling a bit grumpy some days, but... no more Endo pain, which feels amazing. The side effects were not constant and were totally manageable. Hot flushes were the worst side effect, and although I have about 1 an hour, they only last a couple of minutes. Not looking forward to coming off it."

• col...
• Taken for 1 to 6 months
• March 7, 2023

For Prostate Cancer "Early-stage prostate cancer. Now on the third session of the Zoladex implant. PSA rapidly reduced. No night sweats or mood swings. Definite muscle and energy loss despite regular visits to the gym to try and keep fit. Small price to pay."

• Anonymous
• Taken for 1 to 6 months
• September 7, 2018

For Endometriosis "I had a laparoscopy to treat endometriosis a month before beginning the course of treatment. Monthly dose. On implant 3 of 6. The first month was the most difficult. No period after the first month. Chronic pelvic pain has subsided. Pain and bleeding on the injection site, bloating, nausea, fatigue, lethargy, dizziness, aches and pains, a heavy feeling in the chest, and pelvic cramps for a few days after injection. Hot flushes and night sweats gradually became more intense and frequent after the first month. They’re bothersome. Emotionally up and down throughout treatment with bouts of depression, anxiety, and panic attacks (have a history). Headaches, a possible cause of sleep deprivation in combination with the drug. Weight, appetite, skin, and hair - normal. I’m conflicted with how I feel about the drug. I can say not having chronic pelvic pain and a period has been relieving."

• Mol...
• March 5, 2017

For Bleeding Disorder "Stopped periods as expected, great news, no more heavy bleeding, stopped chronic pain that dropped me to my knees when standing or moving. Downsides are memory loss, chronic fatigue, bone pain, loss of hair, sore breasts. I'm on Zoladex 3.6 once a month with HRT injection number 4. Overall, I'm in less pain but still struggling with everyday tasks and to carry on working as a normal, healthy 36-year-old woman should. I should be able to roll on coming off this drug and having my hysterectomy."

• Mar...
• Taken for 1 to 6 months
• January 15, 2022

For Endometriosis "Have had the 3rd Zoladex implant, and the side effects are ramping up. Was born with uterine didelphys, so had issues for years - heavy bleeding, pain, endometriosis, and horrific PMDD (like PMS but so much worse). Unsuccessful endometrial ablation, so started Zoladex to see how I cope with no hormones. Wow. Mental health greatly improved. Side effects only start after 5 weeks, and now they’re pretty intense - hot flashes, insomnia, weight gain, fatigue, vaginal dryness, and, grossly enough - leaking of urine! The last side effect has made me quite alarmed, but it can happen, my gynae says. Hopefully, have a hysterectomy soon where they’ll take the ovaries too. The benefits to my mental health far outweigh the annoyance of the side effects."

• CBL...
• Taken for 6 months to 1 year
• January 25, 2022

For Endometriosis "Diagnosed at 29, Zoladex for 6 months. Endo pain only subsided since you do not get periods while taking this drug. However, I experienced terrible inflammation and water weight gain, my clothes stopped fitting after the second injection. I work out and eat healthy, mind you. I am constantly fatigued and lack motivation. Brain fog is real on this drug. The hot flashes are so miserable, couple it with the insomnia and it has been a miserable 5 months. The cellulite and weight gain have been the hardest for me since I am into fitness. I feel like I’m in someone else’s body. I get headaches daily and usually suffer a migraine within 24 hours of a dosed injection. I’m on my last dose and I’m hoping after I can get back to my normal self. I dealt with sciatic pain with the endo, it’s not as bad but still around. I’m still trying to figure out if this treatment has been worth it. We shall see by April."

• Swi...
• Taken for 1 to 6 months
• March 29, 2022

For Endometriosis "This is my second month for this injection, the first month was so bad. I had too many side effects. The night after my injection, I had hot flashes and painful bones, especially on my ankles. Day after day, it gets worse, I had dizziness every day, constant tiredness without reason, and super fatigue, muscle pain, super vaginal dryness, and couldn’t walk longer because my feet and legs hurt so bad. But there are also good side effects, like I’m totally no more bleeding/period or even spotting, so it means no pain."