Evolocumab for High Cholesterol User Reviews (Page 5)

• Mr ...
• Taken for 1 to 6 months
• June 13, 2016

"I have muscle aches with statins. I tried Repatha and did fine for a month or so. It lowered total cholesterol to 120. Then, one day after an injection in my right leg, I got severe right leg cramps. It took two more injections to tie the leg pain to the injections. I thought it might be gout. An orthopedic doctor said it was a torn tendon in the knee. Pain was at a level of 2-8, and I could hardly walk. It settled in the knees. I'm about 10 days since the last injection, and the pain is less every day. I'm definitely sure it's the drug as I have never had knee problems. I hope there is no permanent damage."

• Red...
• Taken for 1 to 6 months
• December 1, 2018

"I put my experience up some time ago, and now I have taken my 7th injection. My neck is hurting so bad I don't think I can continue on this medication. Dizziness is bad, and back pain. Going to contact my cardiologist to try and stop this nonsense."

• Ano...
• Taken for 2 to 5 years
• July 30, 2025

"High cholesterol runs in my immediate family. I was next to the oldest of six children. To date we have lost 3 of them. Two definitely had high cholesterol. My two sisters died of it, and the 3rd sibling drowned in a kayak accident. My mom died of a heart condition, and my dad lived on until 95. My maternal grandfather died of heart issues, my grandmother from lung disease. My cholesterol was over 300, and so was the lip something. There wasn't much I could tolerate, so I was hopeless until my doctor prescribed Repatha. The only problem I am having after about 3 years on it is the injection itself. Sometimes it does not work. In fact, I collected 4 injections that I am returning because they do not work. I waited half an hour after taking them out of the refrigerator. In any case, my cholesterol dropped well below 200, maybe 140, and so did my triple, etc. reading. My younger sister is now on it."

• duh...
• July 5, 2021

"I have taken 4 statins in the past five years, all leaving me with leg pain, which gets worse with walking. Stopped each pill within weeks, as I would rather have quality of life. Physician recommended Repatha. No leg pain for two months, however, I experienced constantly being tired. Blamed it on old age (80). After my last injection, I couldn't walk 50 feet without being out of breath. I decided to check side effects, and of course, the #1 is trouble breathing. A little farther down the list is tired and drowsy. I'll live with the cholesterol. I pray the effects go away, I still have them a week later."

• Jms...
• Taken for 1 to 6 months
• July 6, 2021

"I have gained weight on every statin I've been on. My NP said I want you to try Repatha. I've read and have had great reports with people who can't take statins like yourself. So I was happy there was hope for my condition. I went home, looked up weight gain as a side effect. Researched all I could. I started it 8 weeks ago. I had back surgery the week prior. I've been gaining weight. I finally looked up 'I have been gaining weight on Repatha.' I couldn't believe it. It is a side effect. I've also read it only helps 1 out of 66 people from having a heart attack or stroke. What!! I will take my chances. I have also felt very uneasy, not myself, short with my family, gaining weight, body aches, thinning hair, and earaches!!!"

• Poi...
• Taken for 6 months to 1 year
• December 15, 2019

"Call Amgen, who makes this poison. It takes months before it’s out of your system. This is horrible, this Repatha is so bad for all of us. Please, everyone, call the FDA, file a report, they need to know all these side effects. Look at the poor person who has stage 4 lung cancer."

• Rex...
• Taken for 1 to 6 months
• December 2, 2023

"One month after two two-week injections of Repatha, blood test shows great control of LDL and general cholesterol, but a significant rise in A1C, neutropenia, upper respiratory infection, especially in both nostrils responsive to Bacitracin, general muscle fatigue, terrible low mood, and social withdrawal, significant cognitive/psychosocial impairment. Physicians never tell patients what to expect, they just write the prescription and wish you luck."

• Net...
• Taken for 1 to 2 years
• October 22, 2019

"After taking Repatha for a year and a half, my cholesterol was lowered dramatically. But I had sinus infections that got worse, respiratory infections, and was diagnosed with COPD 1 year ago after taking Repatha faithfully. I have always had sinus problems and seasonal asthma, and bronchitis, maybe once a year I had to use an inhaler. Since being on Repatha, I have had asthma attacks and pneumonia so bad I had to be hospitalized. Exactly 4 times in a year. I never smoked, and now I am on 3 inhalers and a nebulizer. I have always had a pneumonia shot every 5 years and never got pneumonia for over 15 years. I am fatigued and have muscle pain. I decided to stop Repatha on my own and see what happens."

• Dav...
• Taken for 6 months to 1 year
• December 29, 2018

"I used Repatha for 12 months and was pain-free for the first 8 months. Thereafter, pain started growing in the right leg just below and above the right knee. The muscle in this area became so sore that by the 11th month of use I could not walk without a limp. On the 12th and final month, I discontinued the Repatha as I could no longer climb a stairway with my damaged right leg muscle. Two weeks have passed since my last Repatha dose, and my leg muscle pain is 95% gone. The Repatha did lower my LDL to 52, which was great, but what damage it was doing to my leg muscle, and any other parts of my body I'm not aware of, I just don't know. It is virtually the same to my body as was any of the statins I tried. None of them worked for me at age 77 years, male, and in very good health other than high cholesterol."

• Ver...
• Taken for 2 to 5 years
• December 1, 2019

"Just like all of you, I have been on Repatha, and my quality of life has failed, so I stopped it and still have all the side effects. I now read that the FDA has 8 reports, including 2 deaths with lung cancer. So really, they are aware and not doing anything about this drug. We need to all call the FDA and file an adverse report, so hopefully, they remove it from the market, which is highly unlikely. Just like someone said, it’s about the money. And also report it to Amgen Pharm +1-888-463-6332. What is wrong with this FDA?"

• Che...
• Taken for 2 to 5 years
• February 19, 2020

"I have had very high cholesterol, and I cannot take statins. My cholesterol doctor recommended Repatha. I have been taking it for about two years now. My cholesterol is better, not perfect. The only side effects I have experienced are some back pain and some insomnia. I can walk two miles without increased pain. My blood work has been good so far. For the most part, I seem to be able to tolerate Repatha much better than statin pills."

• jdw...
• June 25, 2021

"I have been on Repatha for 2 months, and I have had 4 injections. I am allergic to statins. No side effects at first, but eventually, I began to feel anxious/nervous. These are issues I have not dealt with in the past, prior to Repatha, and nothing has changed in my life that might explain these feelings. As I reviewed the formal list of possible side effects, I saw nothing listed for feelings of anxiety or nervousness, so I decided to give it more time. More time has resulted in no improvement, so I googled my issues and found this site. While not as common as side effects with muscle pain and cough/cold-like symptoms, I have read of some experiences similar to mine. I will be having my cholesterol checked soon. After that, I will stop taking Repatha to see if my anxiety goes away."

• Cga...
• May 16, 2021

"I started Repatha because statins were causing heartburn, muscle aches, and dry mouth. After the first dose, I was OK, but after the second dose, I had a nosebleed that soaked several paper towels and lasted about 15 minutes. I googled to find out if that is normal and found that nosebleeds are common in women over 60, which I am. I also had constant nose dripping like water and fatigue so bad that I could hardly make it to my mailbox. Some shortness of breath as well. After several unexpected nosebleeds at very inopportune times, I stopped it."

• Pop...
• Taken for less than 1 month
• December 14, 2019

"Took two Repatha injections (over a two-week period) and then went to the ER and spent 4 days in the hospital. Two weeks later, I am still in severe pain. Lower back, in the liver area, feels very sharp and burning pain. Shingle-like pain throughout the upper body. I thought I was having a heart attack at one point. Taking pain pills every 4 hours just to exist. Terrible, evil drug."

• shi...
• October 13, 2022

"Repatha is dangerous with muscle and joint, sinus, yeast infections, runny nose continue every day. The worst is muscle and joint after 6 injections in Oct. 2022. I quit, I would rather die. This should be reported. Do not take it, doctors lie to you."

• Tak...
• Taken for 6 months to 1 year
• August 31, 2018

"I have been on Repatha for about eight months because I cannot take statins. I have had some bad side effects: joint pain, back pain, and continuous sinus drainage. Can go to sleep, fatigue bad. High blood sugar. And I feel it has eaten my stomach lining out. I can't eat much of anything. I have been off of it for 30 days and hope and pray this medicine gets out of my system before 3 months. I will have to see if I can keep my cholesterol down with diet. This stuff feels like it is killing me. Would never recommend it at all."

• San...
• Taken for 1 to 6 months
• June 30, 2018

"I am a 71-year-old male and in relatively good shape. I was working out and riding my bike 10-15 miles a day. I have chronic high cholesterol (300 overall). I cannot tolerate statins. I started taking Repatha on March 3, 2018. Shortly after the second injection, I developed sinus issues (bloody nasal discharge), headaches, muscle/joint pain, muscle weakness, arrhythmia, diarrhea, and severe debilitating back pain. I did not immediately make the correlation with the Repatha injections. I made an appointment with my GP, and he took me off Repatha. My last injection was May 13, 2018. The symptoms have improved but are still present. I only hope the side effects are reversible. The quality of my life has been significantly impacted. I am disappointed. Repatha did lower my cholesterol, but the side effects are hardly worth it. Research this drug before you inject it."

• Lyn...
• Taken for 1 to 2 years
• September 26, 2018

"I started using this on 5/17. Effects after first taking were very bad. Got very sick, like the flu. Wasn’t going to take any more, but I talked to a pharmacist who suggested I give it another try. I couldn’t take statins, so this was prescribed. My cholesterol was over 300. Side effects seemed to be not as bad. My cholesterol went to perfect numbers. But now, over a year on this, my blood platelets have dropped. A lot of bruising. My red blood cells have enlarged and fewer of them. I have stopped taking this drug. Hoping my blood levels can be restored. Have been referred to a hematologist. Do not recommend. Wish I had done more research instead of just listening to my doctors."

• Ste...
• Taken for 1 to 6 months
• October 21, 2017

"I am 69 years old. I have been an athlete all my life and have run over forty thousand miles. I do not tolerate statins due to severe muscle pain. I was walking 6 miles a day prior to taking Repatha. After three shots of Repatha, I developed debilitating pain and weakness in my back and right leg. 9 on the pain scale. I still, three weeks later, have difficulty walking. It seems to be improving somewhat, with better days followed by a more difficult day. This has had a terrible impact on my quality of life. DO NOT TAKE this drug!"

• Bet...
• Taken for 1 to 6 months
• May 3, 2019

"I have had 3 Repatha injections so far. My 3rd injection was on a Friday. That night I woke up with chest pains. I am a heart patient. Have 1 stent. I thought maybe my heart was acting up again. Went to my doctor, told him. I asked if it could be the Repatha. He said he really didn't know. Wasn't a lot of info on it yet. He only has 3 patients on it. That weekend, still had pinches in my heart and nausea, where I vomited. (No, it wasn't a heart attack.) By Tuesday, no more pinches in my heart. I really think it was the Repatha. Scared to take another injection in case it does make me have a heart attack."

• Can...
• Taken for 1 to 6 months
• September 9, 2018

"I took Repatha for 6 weeks and started to feel lethargic. I also had lower back pain and was lightheaded with bouts of dizziness. After discontinuing Repatha, it took 6 weeks to start to feel better. Repatha was very effective at reducing my cholesterol, but I could not handle the side effects. I just hope that I will eventually feel normal."

• njb...
• Taken for 1 to 6 months
• August 30, 2017

"Took 3 shots of Repatha. OK after the first one, but after the 2nd and 3rd, I began to feel bad. Had back aches, soreness in hips and knees. Difficulty in climbing stairs. Blood work showed that it did lower my total cholesterol and LDL. However, I feel that this drug is not worth the serious side effects which I experienced."

• Jkw...
• Taken for 1 to 6 months
• August 13, 2025

"I’ve had high cholesterol since I was a child, it’s genetic and runs in my family. I’ve been on and off statins throughout the years and developed a severe reaction to them about six years ago. It took two years to diagnose the issue, and I had to stop statins immediately upon diagnosis – my cholesterol, at best, on statins was 245. Obviously, it skyrocketed after stopping statins. Both of my doctors decided I should try Repatha, and I started it in February 2025 with my overall cholesterol being 319, highest at 388. I had minimal hopes and was not thrilled about a biweekly injection, but at my six-month follow-up today, for the first time in as long as I can remember, my overall cholesterol was 171, with everything falling in the normal range. I honestly can’t remember the last time my cholesterol was in the normal range, not just part of it but all of it. I have had zero side effects, a little adaptation to remembering the injection, but am overall thrilled with this medication."

• Edd...
• Taken for 6 months to 1 year
• August 13, 2025

"Finally, something that works and doesn’t hurt my back or legs. I take it when I take my Ozempic. My cholesterol is low now, and I have one less thing to worry about. Insurance is covering it, and I got to stop my Crestor that was hurting my back."

• Min...
• March 8, 2019

"My mother took Repatha. If you are taking this medication, watch for memory loss, having a hard time walking, anything not normal. This medication just about killed my mother. From heart problems to liver. Her memory confusion started mild, along with the walking problems. She went from walking on her own to a cane to a walker. She is 3 weeks from the last shot, and finally, she can walk with the walker again, and yet she had been really bad last month and a half. Thought we were going to lose her. Please be careful with Repatha."