Tri-Estarylla and Depression: What Users Say

• sue...
• Taken for 1 to 6 months
• February 3, 2021

For Birth Control "This birth control is horrible. My last birth control was discontinued, so they switched me to this. I got pregnant on this medication, and when I had continued using it after pregnancy, I had the worst depression and anxiety of my life and legit thought I was bipolar. I know everyone is different, but I do not recommend this medication."

• Anonymous
• Taken for 6 months to 1 year
• March 12, 2022

For Birth Control "Wow! This birth control was a true nightmare for me. By the 3rd week, I was feeling every side effect in the book—from depression to anxiety to being irritable in a quick second, tender breasts, cystic breakouts (mind you, I don’t break out other than a pimple here and there). This was full-on cystic acne around my jaw and mouth. I didn’t want to leave the house for weeks. I felt isolated in my thoughts. I have never felt depression like I did on this pill. I tried to stick with this one because I was told it would “regulate,” but after 2 months and 3 days, I broke down in my bed, shaking from anxiety and crying—I made the decision to quit it."

• Gli...
• Taken for less than 1 month
• November 15, 2021

For Birth Control "This pill has the worst side effect ever! Gave me a lot of mouth sores that are very painful, it reached the point where I can’t eat, and my face got swollen. I am a regular 28-day cycle, and my period lasts only for 3 days, the max is 5, but with this pill I’m bleeding more than 10 days, and it looks like fresh blood. The depression is severe too, having a lot of crying spells. I stopped taking it just before the week of placebo because the mouth sores are worsening and the depression too. I know some pills work for different types of bodies, so I guess this pill is not for me. No good benefits and all bad side effects."

• Ano...
• Taken for 1 to 6 months
• October 6, 2020

For Birth Control "I know this has a load of negative reviews, but you need to realize that everyone's experience is different! I was super nervous to take Tri-Estarylla because my body has always had negative reactions to every medication ever, so you should at least give this a try and don’t let the negative reviews scare you too much. I have been on this medication for a month now. I was prescribed by Pill Club to take it because my primary care physician was trying to put me on Nexplanon, which I did not want to be on. The first 2 weeks that I was on Tri-Estarylla were really hard: constant nausea, threw up every single thing that I ate, mood swings, depression, every horrible thing you can think of. But these last 2 weeks though, I feel like I’m on no medication at all. I’m not throwing up anymore, I feel happier, everything has finally lightened up. I’ve tried loads of birth control, but none of them only took 2 weeks to stop hurting me, so I would completely recommend this."

• Sie...
• Taken for 1 to 6 months
• September 13, 2019

For Birth Control "I hate this brand of pill so much-Tri-Estarylla! I've only used it because of The Pill Club. They switched me to this because it was a generic for Tri-Sprintec, but it was honestly the worst couple of months of my life. This pill makes my sex drive absolutely disappear, which is really tough on my relationship. The only upside to it is that I didn't get pregnant with it (probably because I had no sex drive!). It also makes me feel more depressed and fatigued than other brands."

• Kat...
• Taken for 1 to 6 months
• April 9, 2018

For Acne "For the first couple of months, I was so moody and irritable. It got so bad sometimes I almost gave up, but I stuck with it. My acne was not improving, but by the third month, I really started to notice a difference. Five months later, my acne is almost completely cleared up, and I don't suffer from the depression or anxiety I had before starting this pill and in the early stages. It also helped to regulate my periods, which used to be all over the place."

• Anonymous
• Taken for 1 to 6 months
• April 26, 2023

For Birth Control "I was originally on Tri-Sprintec for 8 months before I was switched to Tri-Estarylla because the pharmacy I went to didn't have Tri-Sprintec. I've been on Tri-Estarylla for about 2 months now, and it's been awful. I've noticed a complete decline in my mental health; extremely exhausted, have no energy, am moody and have constant mood swings, am stressed, easily irritable, and the list goes on. I feel depressed and miserable; I haven't been able to eat well, and I don't feel capable of doing things I used to be able to do fine. I'm a student and I have no motivation to go to classes or do my work, so my grades are dropping. Everything that could go wrong has gone wrong. I have never felt this way ever, and I was completely fine on Tri-Sprintec. The only benefits I've gotten are I'm free of pregnancy, and it's been treating my acne, but these are not worth the complete toll it has taken on my mental health."

• Anonymous
• Taken for 1 to 6 months
• April 26, 2023

For Birth Control "I was originally on Tri-Sprintec for 8 months before I was switched to Tri-Estarylla because the pharmacy I went to didn't have Tri-Sprintec. I've been on Tri-Estarylla for about 2 months now, and it's been awful. I've noticed a complete decline in my mental health; extremely exhausted, have no energy, am moody and have constant mood swings, am stressed, easily irritable, and the list goes on. I feel depressed and miserable; I haven't been able to eat well, and I don't feel capable of doing things I used to be able to do fine. I'm a student and I have no motivation to go to classes or do my work, so my grades are dropping. Everything that could go wrong has gone wrong. I have never felt this way ever, and I was completely fine on Tri-Sprintec. The only benefits I've gotten are I'm free of pregnancy, and it's been treating my acne, but these are not worth the complete toll it has taken on my mental health."

• Anonymous
• Taken for 1 to 6 months
• April 26, 2023

For Birth Control "I was originally on Tri-Sprintec for 8 months before I was switched to Tri-Estarylla because the pharmacy I went to didn't have Tri-Sprintec. I've been on Tri-Estarylla for about 2 months now, and it's been awful. I've noticed a complete decline in my mental health; extremely exhausted, have no energy, am moody and have constant mood swings, am stressed, easily irritable, and the list goes on. I feel depressed and miserable; I haven't been able to eat well, and I don't feel capable of doing things I used to be able to do fine. I'm a student and I have no motivation to go to classes or do my work, so my grades are dropping. Everything that could go wrong has gone wrong. I have never felt this way ever, and I was completely fine on Tri-Sprintec. The only benefits I've gotten are I'm free of pregnancy, and it's been treating my acne, but these are not worth the complete toll it has taken on my mental health."

• lex...
• July 29, 2017

For Birth Control "I'm generally not sensitive to medicine at all. I was on Ortho Tri-Cyclen for about 6 years with no side effects. Due to insurance reasons, I was forced to take the generic, Tri-Estarylla. Within a week, my mental health diminished. I felt constant anxiety, depression, paranoia, and moodiness. I was wracking my brain trying to figure out what was different in my daily life but could not identify any other source of stress. So I decided to look up reviews for this horrendous pill. Lo and behold, hundreds of negative reviews with women reporting the same side effects. This is my second month on it, thinking the first month was a fluke. This drug should be taken off the market, period."

• The...
• Taken for less than 1 month
• June 13, 2018

For Abnormal Uterine Bleeding "So, my Dr. switched me to this from Ortho Lo (which I never had an issue with besides some minor sadness) as a couple of months ago I bled for a month straight. She told me to try this BC because it’s the same dosage every day. I have never been so riddled with anxiety and depression. I’m having emotional outbursts, and I cannot fully rationalize why. I am a generally sensitive person, but this is on another level. I’m going back to Ortho Lo or something else because honestly, this put me in such a dark place."

• Car...
• Taken for less than 1 month
• January 30, 2018

For Birth Control "I recently switched to this pill about 4 weeks ago. It was fine until week 2 when I started to get super emotional about everything and get into horrible mood swings. After 4 weeks now, I have severe anxiety over everything, I am depressed for no reason, and I have constant negative thoughts. I am also constantly jittery and worried about everything, and my headaches have gotten so much worse. Horrible, horrible birth control. I would not recommend this to any women."

• Ano...
• Taken for 1 to 2 years
• July 14, 2019

For Abnormal Uterine Bleeding "I was taking this pill on and off for irregular periods between the ages of 15-17 (I am 19 now and recently discovered I have PCOS). While it regulated my periods, man, the side effects were awful! I was depressed to the point of feeling like I was in a dark, dark hole, my anger was out of control, and I gained 40 pounds. There are much more effective pills with fewer side effects out there - glad I switched!"

• Rae...
• Taken for 1 to 6 months
• February 27, 2018

For Birth Control "My experience with this drug has actually been pretty good. I did have mild acne breakouts and some bloating and water weight gain. These all went away pretty quickly, though. The only major side effect I've had is significant bleeding between periods. However, I had fewer and lighter cramps and no ovarian pain like I dealt with before, and no depression/mood swings or any of the other side effects that other users have experienced."

• Mik...
• Taken for 1 to 6 months
• March 12, 2023

For Birth Control "I like that I didn’t get pregnant, didn’t gain weight, and had no acne. However, I have lost any spark or motivation for life that I used to have, and low-key am depressed and just want to give up. Besides that, I’m thriving, I guess - I’m switching."

• Sou...
• Taken for 1 to 2 years
• May 11, 2017

For Birth Control "My pharmacy switched me to this medication, and I never thought twice about it, as I have been on several different BC pills with no side effects. I didn't realize my horrible medical conditions were a result of this medication until I missed starting a new pack 3 weeks ago, and my problems almost immediately went away. For the last year and a half on the medication, I had unbearable migraines all day, 7 days a week. I also experienced constant nausea and dry heaving to the point that I would have to pull off the road when driving to throw up. I would become so dizzy when I was nauseous that all I could do was lay on the bathroom floor. I became very depressed, but can't say if it was due to the medication or being miserable every day."

• Ter...
• Taken for 2 to 5 years
• June 21, 2022

For Birth Control "I started taking this as a generic replacement for my original prescription 3 months into trying birth control to regulate my period. Previfem wasn’t too bad, but I did notice a lot of changes. When I got Tri-Estarylla instead, I just assumed it had a similar adjustment period. However, I’ve been on Tri-Estarylla now for two years and 3 months. Since starting this medication, I’ve become depressed, anxious, constantly nauseous, constantly tired, and constantly having headaches of varying severity. There were many days when I would avoid driving because my headaches were so bad that I had problems seeing and focusing. I have also gained 38 lbs during this time, which has not helped at all with all the other issues this drug caused. I’ve become an emotional mess with mood swings that make no sense at all. After taking it, I cry out of nowhere, for no reason at all. Everyone is different, but I do not recommend. I followed instructions to a T and never skipped a day."

• lol...
• October 14, 2017

For Birth Control "I didn’t like this pill. I stayed on it a full 3 months, but it made me crazy. The week before my period, I became even more crazy and depressed and anxious. Pretty much sad every day. Then I started getting my period the last week of my active pill and acne all over my chin. Switched pills."

• lol...
• October 14, 2017

For Birth Control "I didn’t like this pill. I stayed on it a full 3 months, but it made me crazy. The week before my period, I became even more crazy and depressed and anxious. Pretty much sad every day. Then I started getting my period the last week of my active pill and acne all over my chin. Switched pills."

• Awf...
• Taken for 6 months to 1 year
• January 5, 2022

For Birth Control "I was switched onto Tri-Estarylla from Tri-Sprintec (which was generic for Tri-Previfem) for whatever reason. The pharmacy didn't tell me, but I assumed it was a rebrand and the same thing as Tri-Sprintec, but it is NOT the same. Tri-Estarylla has been awful for me. Very depressed, withdrawn, lethargic, and severe weight gain, like 20 pounds weight gain. The weight gain adds to the depression too. And I eat fairly healthy and exercise 5-6 times a week, but the weight kept going on no matter what I did. I don't like this pill, and I have requested my doctor and pharmacy to make a note to never replace Tri-Sprintec with this Tri-Estarylla ever again. This pill prevented pregnancy and lightened my period, but I am so unhappy with the weight gain and tiredness I experienced. I get to go back on Tri-Sprintec now thankfully."

• Jam...
• Taken for 1 to 6 months
• November 8, 2021

For Birth Control "Switched from the generic form of Junel 1/20 (was on it for 6 months). I've been on Tri-Estarylla for about 2 months now. So far, no significant side effects besides bloating and weight gain (that could be a new relationship though, lol). Junel 1/20 gave me intense side effects such as acne/rash, depression, mood swings, loss of sex drive, bloating 24/7, and breakthrough bleeding for 2 out of 4 weeks a month. With Tri-Estarylla, my period is heavier though and lasts 4 days mid-placebo pills with cramps starting the last week of active pills all the way through the end of the placebo week. Haven't seen much improvement in acne, but I haven't been on it for too long to see that. My sex drive has improved, and I haven't had any breakthrough bleeding or mood swings. My discharge is much heavier/thicker, but it's white and not dark brown like with my last birth control. No pregnancy scares, and this is the only form of birth control my partner and I use."

• Eil...
• Taken for 1 to 6 months
• August 28, 2022

For Birth Control "Nurx switched me from Tri-Lo Sprintec to this Tri-Estarylla. Now, 5 months in, and each month I sink deeper into low energy and am constantly hungry. I know to take vitamin D and B to help fend off side effects, but this pill is winning. Now, I'm noticing the depression, having fits of irritability, and I ache all the time. I'm 36, and the last time I went through this mood, I was on another generic about 10 years ago. Generics changing the 'inactive' ingredients are just as important as the hormones."

• Mel...
• Taken for 1 to 6 months
• August 24, 2021

For Birth Control "I took this pill for 3 months because the pill club switched me to it. The first month was fine, nothing that I can think of had changed. But the second month, 2-4 days before my period, I got very bad anxiety and depression to the point I was having muscle spasms in my body. I couldn’t sleep and cried all the time. I didn’t know what was happening. After my period, it slowly started getting better. Then the third month, same thing, 2-4 days before my period, bad anxiety and depression. I stopped taking it right away when I saw all the reviews of others experiencing the same as me."

• DON...
• Taken for less than 1 month
• February 2, 2018

For Birth Control "I only took this medication for two weeks before it drove me so crazy I had to get off of it. It was my first-ever birth control, and within four days, I was already exhausted, breaking out like crazy, experiencing bad cramping, and my depressive symptoms that I had been doing well with for months came back full force. My boyfriend thought I was having a breakdown, I was so emotional and moody. I had zero motivation to do anything and no attention span. Definitely not worth it. Do a different generic or a brand name."

• DON...
• Taken for less than 1 month
• February 2, 2018

For Birth Control "I only took this medication for two weeks before it drove me so crazy I had to get off of it. It was my first-ever birth control, and within four days, I was already exhausted, breaking out like crazy, experiencing bad cramping, and my depressive symptoms that I had been doing well with for months came back full force. My boyfriend thought I was having a breakdown, I was so emotional and moody. I had zero motivation to do anything and no attention span. Definitely not worth it. Do a different generic or a brand name."