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CombiPatch and Spotting: What Users Say

Spotting: mentioned by 5 users (8.5%)

Based on user experiences from 59 CombiPatch reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 22.0%
anxiety 16.9%
bleeding 13.6%
insomnia 11.9%
night sweats 10.2%
spotting 8.5%
cramps 6.8%
vaginal issues 6.8%
bloating 5.1%
depression 5.1%

Reviews for CombiPatch

  • Anonymous
  • Taken for 1 to 6 months
  • August 19, 2022

For Postmenopausal Symptoms "I've been on this patch for a month now. Within 2 weeks, I started spotting. Within 3 weeks, full-on bleeding like I had as a 16-year-old. Constant cramping of my thighs and uterus every day, living on Advil. My body does not seem to like any type of progesterone. How do you determine biopsy negative? My doctor tells me to just keep wearing the patch, my body will adjust. Is this true? And if so, how long does this take? I can't take much more of this. I will say all the menopause symptoms are completely gone, but I'm bleeding, cramping, and have diarrhea every day, so where's the trade-off? Anybody help? Thank you."

9 / 10
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25 Report
  • Sal...
  • Taken for 1 to 6 months
  • February 11, 2022

For Postmenopausal Symptoms "Works great for me. No more hot flashes! Vaginal prolapse is less bothersome! Some minor spotting weeks 3-5, but not enough to use a liner or pad. The adhesive sticks fine and does not cause me skin irritation. I am 3 years post-menopausal and wish I had started CombiPatch sooner!"

10 / 10
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12 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 5, 2015

For Postmenopausal Symptoms "My symptoms were slight, including flashes at night and some insomnia. Vaginal dryness was another concern. The patch has really helped. It's been almost a year since I started the patch. Early on, I had some spotting, but that has stopped. I am having some puffiness in the application area."

10 / 10
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22 Report
  • Lyn...
  • Taken for 1 to 6 months
  • February 22, 2018

For Atrophic Vaginitis "I have been on the patch for 4 months after trying to use estrogen cream, which did not work and made the burning and pain worse. I did not want to try anything else in my vaginal area, so I suggested the patch to my doctor. I like that it is transdermal and does not go directly through my liver. I am on the higher progestin dose, but am now experiencing spotting. I had a uterine biopsy that was negative, but still am spotting. My OBGYN is considering changing my HRT, but I have had success with this patch. Burning and pain that I experienced every day were gone in just 1 week. I used a vaginal moisturizer for a week or so to help speed up the process. I no longer use a vaginal moisturizer. The hot flashes I had are gone, and I can sleep all night without waking up, no more night sweats. It's convenient, but the patch leaves a sticky residue you have to scrub off, but well worth the benefits. My insurance did cover this at a $75.00 co-pay, but the coupon online brought it down to $25.00."

10 / 10
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16 Report
  • Kri...
  • Taken for 6 months to 1 year
  • November 9, 2021

For Postmenopausal Symptoms "I’m 48, have been using CombiPatch for almost a year now. Last period was July 2018. I had been suffering with progressively worse night sweats and daytime hot flashes to the point where it was affecting my quality of life. It was a few weeks before I noticed fewer hot flashes, and after a month or so, I no longer had any. I did have spotting and about 4-5 periods within the first six months of using it (brownish red in color, not red like pre-menopause). I went in for regular check-ups with my doctor while this was happening and had a transvaginal ultrasound as a precaution, and everything checked out. I did gain some belly weight and have some hair thinning, but this could have been normal menopause that caused it vs. the patch. I’ve always been healthy, eat well, and exercise regularly. I would highly recommend it. It did not do much for the painful menopause sex, but together with Vagifem inserts, it’s been a lifesaver. Coupon online that makes it $25/month with my insurance."

9 / 10
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5 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.