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User Reviews for Divalproex sodium to treat Migraine Prevention

Also known as: Depakote, Depakote ER, Depakote Sprinkles

Divalproex sodium has an average rating of 6.2 out of 10 from a total of 74 ratings for the treatment of Migraine Prevention. 51% of users who reviewed this medication reported a positive effect, while 28% reported a negative effect.

Divalproex sodium Rating Summary

6.2/10 average rating

74 ratings from 77 user reviews.

Compare all 58 medications used in the treatment of Migraine Prevention.

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14%
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4%
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3%
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Reviews for Divalproex sodium

Coco · Taken for 5 to 10 years October 25, 2020

Depakote (divalproex sodium): “I was terrified to try Depakote for migraines. I tried a dozen other drugs that didn’t work or eventually lost their effectiveness so I was basically left w/ no choice. I started taking it at night and it really helped w/sleep. In about 1-2 weeks I felt like a new person. My migraines were lessoned as well as the intensity. I monitored my diet faithfully and exercised when I was in less pain. And I never stopped praying it would continue to help me. Please don’t be as terrified as I was. At least try it...”

9 / 10
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Boss Lady · Taken for 1 to 6 months April 27, 2019

Depakote (divalproex sodium): “I was on Depakote 500 mg once a day with no effect on my migraines. BUT I have noticed I’m no longer impulsively spending. So I guess it’s possible that I’m bipolar as well...? My doctor has upped my dose to twice a day and so far so good. No headache this month and adding to my savings every week lol.”

7 / 10
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Rhonda4realestate · Taken for 1 to 6 months December 9, 2020

Depakote (divalproex sodium): “I've had migraines since the age of 12 and I'm in my mid fifties. I had chronic common migraines for years, up to about 15 or more a month. Tried every prophylactic out there with no success until I tried Depakote 500mg ER at night. Took about 2 weeks and I have not had a headache in over a month, and when I do have one I take 50 mg of Sumatriptan and its gone in 10 minutes. Its been a miracle for me and has changed my life! Only side effect is increased hunger but I'm managing that. I take that over pain that took over my life any day!”

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Toban M October 15, 2013

Depakote ER (divalproex sodium): “I've also been trying different preventive medication for migraines with my doctor and so far Depakote is working the best. I started with 250mg a day for the first week, now at 500 mg a day. Before this medication, I would wake up daily with chronic head pain in the neck or behind the eyes. Now I wake up almost every morning with a clear head. I haven't seen any side effects yet at this dosage and I've even lost weight since I've been proactive with daily exercise. I started walking 2 miles daily since taking this medication. With proactive exercise and eating habits, I think anyone can keep potential side effects at bay. Previously, I was on Topamax and had to stop taking it as the nausea/head fuzz was too severe for my line of work.”

9 / 10
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Barb · Taken for 10 years or more January 14, 2020

Depakote (divalproex sodium): “I have been taking Depakote over 20 years for migraines. Tried everything out there and this is the only drug that helped at all. I had no side effects. However, after about 15 years, I had to increase the dose from 500 to 1,000 daily. About four years after that, found that my osteoporosis had significantly worsened. Just a warning if you are a woman nearing menopause or past menopause, keep an eye on bone density as this drug can potentially reduce that with long-term use or high dosage.”

7 / 10
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handclutch May 1, 2009

Depakote (divalproex sodium): “I've suffered with bad migraines as far back as I can remember and finally after 52 years they got so severe I ended up in hospital. A new doctor took my history and decided to try Depakote (500mg) for 2 weeks and then in 2 weeks double the dose. I started with the 500mg and never had to double the dose. This July 2nd 09 it will have been 2 years without any kind of headache. Not even a little one. THANKS Depakote.”

10 / 10
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Anonymous · Taken for 1 to 6 months July 3, 2019

Depakote (divalproex sodium): “My 14 year old son went on Depaokote about 3 months ago for abdominal migraines and head migraines. After trying a number of other migraine medicines Depakote was the only medication that stopped the continual vomiting, nausea and headache he had be experiencing for over 2 months. It did take 4 weeks for the medication to build up in his system to prevent the symptoms. He is now on 750 mg of Depakote and feeling great! The only side effect he is experiencing is weight gain, but we believe with proper diet and exercise he will be able to control that.”

9 / 10
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Becca1248 · Taken for 1 to 6 months August 29, 2014

Depakote (divalproex sodium): “Used this for a few months as recommended to prevent my frequent and painful migraines that I've had since I was 12. Depakote was okay I guess. I still had two major migraines while on it, and didn't give it any extra time because the side effects are awful! I wanted to sleep constantly. Felt depressed and irritable, and hated life! Plus, the weight gain alone I experienced in a couple months was absolutely enough reason for me to not want to be on it anymore.... I gained about 15-20 lbs!”

3 / 10
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Overhead January 1, 2020

Depakote (divalproex sodium): “In 1994 I was in a Semi truck collision. A one ton Ford hit my Semi flatbed loaded with three fork lifts. I received whip lash side ways then the fork lifts broke the tie downs the force started to throw me through the Cab over windshield my seat belt sat me down. I received whip lash front to back. I did not hit my head or get knocked out, as one Doctor stated. I had sharp severe headache's. For months I was allowed to take 10 aspirin a day, 300 a months. A year later I went to Portland Oregon, I found Dr. Christina Peterson she told me I was having rebound headache's. She put me on Depakote twice a day maybe 250 mg not positive. It was a miracle. I was able to work again.”

10 / 10
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Cowboy 61 June 22, 2014

Depakote ER (divalproex sodium): “I have only been taking Depakote ER 500 mg for 10 days now, or maybe I should say nights. I take it at bed time, & was supposed to start taking it twice a day after a week but the upset stomach, the shakes, (or extra nervousness), no sign of relief of my migraines, & I haven't been able to sleep at night either.. I'm going to tell my Dr. that I just can't take it any more.”

1 / 10
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soccerbjsweetie April 3, 2015

Depakote (divalproex sodium): “I have been having migraines for 3 years. I took a beta blocker that didn't work. Then got put on Depakote for migraines. I was on it for a month with no big migraines unless I had my trigger food. Then I realized I gained 5 pounds, was tried all the time and broke out like I had never been before. Medicine works for migraines but has terrible side effects. Had to stop taking”

10 / 10
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Anonymous April 11, 2012

Depakote ER (divalproex sodium): “I had used this medication for more than 15 years, before it stopped preventing my chronic migraine headaches. I was taking it up to 2000 mg per: night daily and didn't have any side effects of it since the very beginning of taking it (in lower dose, of course) and even when took max dose as described. Had a very easy adjusting to it, also and no unpleasanties whatsoever.”

10 / 10
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YDP · Taken for less than 1 month May 11, 2013

Depakote (divalproex sodium): “I've always suffered from migraines. I take 500 ER twice a day and gained 16lbs in less than 3 weeks. Since I'm already overweight this caused severe back pain in which I can barely walk and my legs are numb. Works wonders for my migraine but the side effects aren't worth it!”

4 / 10
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simkitkat66 · Taken for 1 to 2 years April 1, 2018

Depakote (divalproex sodium): “I have a migraine 4 to 6 times per week. I have tried Maxalt, OTC drugs such as Acetaminophen, Excedrin, Advil, PM meds like Advil PM, amitriptyline, and now Depakote. Depakote has done nothing at all to improve my migraines. At this point, I wonder if anything is going to ever help my migraines. All of the meds I mentioned above do not help. I'm at my wit's end. I tried Topamax too a few years ago and it made me so nauseous and didn't help my migraines. I had an MRI done, and the ENT doctor said there were no brain abnormalities seen on the MRI disc. I don't want to be a guinea pig ( hey, try this), or a medical mystery. All I want is some pain relief. Caffeine doesn't help, nor does alcohol. Does anyone have any advice? Thanks!”

1 / 10
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kygent November 17, 2010

Depakote (divalproex sodium): “I have had migraines most of my 67 years. 5 yrs ago I found a Doctor who prescribed Depakote 250 mg. My migraines decreased from one per month to maybe five in the past five years. Taken in combination with sumatriptan succinate tablets (only when I feel the onset of a migraine) I have a life mostly without pain.”

8 / 10
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Cpcmom · Taken for 1 to 6 months July 23, 2014

Depakote (divalproex sodium): “I have struggled with migraines for 14 years. I have tried so many medications over the years. The past 3 years my migraines have gotten worse. I have been put in the hospital for a week to a week and a half at a time. The last time I went to the neurologist they added Depakote twice a day to see if it would help cut back on the number of migraines I was having. I would have at least one a day. I was currently on Topamax twice a day, Fioricet, Zofran. When I started Depakote I noticed my weight was going up well I have been on the medication 3 months now and I have gained 40 pounds. This is so crazy. I used to weigh 298lbs. And I don't want to go back there. When my scale started going over the 200 mark again.”

8 / 10
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Manny05 March 10, 2016

Depakote (divalproex sodium): “Started having migraines about ten years ago. The only treatment that has ever worked for me is Depakote. Everybody is different, but for me this was a Godsend. Nothing worked and Topomax was only a temporary solution. The thing is that after a two month regiment my headaches completely went away. I stopped taking the medication for two or three years before my migraines returned. I went on another regiment and again I went several years without a headache. Yes, I did have slight weight gain, and yes it did affect my ability to perform sexually, but I did not have to continue taking it for more than 3 months. Cysticercosis as a child and a catalyst of factors cause my headaches. Depakote works.”

10 / 10
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CharlotteRosa May 21, 2013

Depakote ER (divalproex sodium): “Medication was very effective at controlling silent migraines but long term use (more than 10 years) has resulted in a 60 pound weight gain, hair loss and shakiness. Recently have felt very fatigued and confused. ”

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Anonymous · Taken for 6 months to 1 year December 14, 2012

Depakote (divalproex sodium): “Before Depakote, I've tried vitamin B2, verapamil, and Topamax, but for one reason or another none of them have worked. About 6 months ago, my doctor started me on Depakote. Once I started using it, my daily headaches became a lot more tolerable, but haven't gone away completely, and my severe migraines are at about once a month. However, like many others, there was a noticeable weight gain--about 20 pounds--soon after I started, and it's been pretty steady since. I've also had a bout of depression recently, but it's hard to tell how that's related to the medicine because it isn't my first time. As of right now, I'm not sure the minor benefits are worth the side effects.”

5 / 10
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PamelaCosta February 5, 2014

Depakote ER (divalproex sodium): “After being on Depakote Er for 8 months, it was really effective in reducing the migraines. As side effects, I never gained one single pound, but the hair loss was just unbearable. I lost half of all my hair. I had to stop taking it, unfortunately. I have always had headaches, since I was a child. Before Depakote, I stayed one month having headaches every single day, had to stay in bed, couldn't even walk, and I felt like I reached the lowest point in my life, I wouldn't be able to live with the pain anymore, I had no life. After 2 weeks on Depakote er 500mg I started getting better. I was having only 8/10 per month. Now I'm on topiramate for 2 weeks, the hair is still falling a lot and the migraines are back, almost everyday.”

8 / 10
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SFLDiver September 8, 2009

Depakote ER (divalproex sodium): “I have been taking Depakote ER for approximately 4 weeks now with good results. Prior to this medication, I was experiencing frequent dull pressure type headaches, some lasting several days, and occasional short duration sharp migraines. Since using Depakote ER, I have had no migraines and only a couple of very mild and short duration pressure headaches. I realize it's only been a short amount of time on this medication, but the relief has been quite noticeable for me. I have also not experienced any sudden weight gain side effects, however, just prior to starting this medication, I commenced a health eating regimen, which has actually caused me to lose several pounds, and which may be contributing to my weight situation.”

9 / 10
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VADiesel February 22, 2017

Depakote (divalproex sodium): “50 Year old male, 6'5" 210 lbs, I have had migraines for ten plus years. I am on 100mgs of Topamax twice a day which gave me four to five migraine a month. Doctor put me on 250mgs Depakote and so far I am down to one migraine a month with no side effects from the Depakote - that I can tell. I call that a win!”

9 / 10
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dfbdar November 12, 2009

Depakote (divalproex sodium): “After years of migraines which continued to get worse. I was getting them almost everyday, and ending up in the ER several times Depakote has come to the rescue. I tried Neurontin, and Topamax both did nothing. It's been several weeks and no headache...what a relief this has been for me. I am praying this continues to work.”

8 / 10
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seanhanamom February 6, 2012

Depakote ER (divalproex sodium): “My 12 year old son has been having migraines for 2 years now. At first it was only once every few months. However, it progressed to once or twice a week - with vision aura and speech disturbance. I took him to a Pediatric Neurologist and he said it was likely from puberty. He prescribed 500 mg of Depakote ER. It seemed to start working right away. It has been almost 2 months now and he has only had one migraine now in almost 2 months. Far better than before. He hasn't had any of the noticeable side effects - hair loss, weight gain. He takes it before bedtime. It is hard to get him up in the morning but don't know if that is from the medicine or from going to bed too late!”

9 / 10
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Jim · Taken for 5 to 10 years April 25, 2018

Depakote (divalproex sodium): “I have been suffering from migraines for about 15 years. On average I would have a migraine at least weekly sometimes more. About 8 years ago I started on Depakote. I went from having migraines at least monthly to 1 or 2 a year. The last count was I hadn't had any for over 2 years. Now just recently I started having migraines more frequently. I have experienced some weight gain but not sure if it's the aging process or the meds.”

9 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.