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Isibloom and Depression: What Users Say

Depression: mentioned by 50 users (17.0%)

Based on user experiences from 294 Isibloom reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 36.1%
mood swings 29.3%
cramps 21.8%
depression 17.0%
acne 15.3%
sexual dysfunction 12.2%
sore breasts 11.2%
headaches 10.9%
anxiety 9.2%
weight gain 9.2%

Reviews for Isibloom

Commonly mentioned side effects
  • syd...
  • Taken for 1 to 6 months
  • March 1, 2019

For Birth Control "Literally, the worst pill I have ever taken. I switched from the last pill I was taking because of extreme depression, but I would honestly rather have extreme depression and cry at all hours of the day than take this. The first three months I thought it was great. Then, slowly but surely, I began to get so irritated. Now I cannot stop lashing out at everyone and everything, when I have never been this type of person. I literally feel nothing at times if I'm not feeling angry, and that is downright scary. I feel like a zombie sometimes. I have no care in the world and am an angry, sad person. I gave it the benefit of the doubt and continued with the pill for three more months, but it literally has just gotten worse, and now I feel like I'm losing my mind. Please don't take this. You will have no motivation or joy."

1 / 10
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  • Anonymous
  • May 31, 2019

For Birth Control "I’m 35. I was prescribed Isibloom before beginning IVF. This is the first birth control that I ever had. My experience is just bad! On pill 3, I started having mood swings and what’s worse, I felt like having pressure in my throat (after 6 hours of taking the pill) - all that continued for like 10-12 hours. On day 4 of the pill, I went crazy - uncontrolled aggression, and started having difficulties breathing. Day 5 - I could not sleep, choked. On day 6 of the pill, I had a sleepless night with heart pain and pain in the back (in the area of the heart or lungs). Today, day 7 - I stopped the pill, I cried the whole morning and decided to stop taking the pill. Other side effects were weight loss (4 pounds in 6 days), no appetite, aggression, crying, insomnia, depression, being scared of everything around. It’s horrible for the first experience. But I thought I would let others know. Of course, we are all unique, and maybe what did not fit me will be good for others."

1 / 10
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  • Anonymous
  • March 8, 2021

For Birth Control "I have been on multiple kinds of birth control and switched to this one because the hormones in all of them affected my mood intensely. This one is one of the worst when it comes to mood swings and cravings. I cry at the drop of a hat and have intense emotional breakdowns constantly for literally no reason and go down the overthinking/anxiety birth control side effects rabbit hole of sadness. I highly do NOT recommend this kind. I chose this kind because it had fewer hormones, and my doctor said it would be better for me in the side effects department. I haven't even gotten a full pack in, and within the first week, felt intense side effects. Don't take this if you have ever experienced depression or anxiety."

1 / 10
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  • Hey...
  • Taken for less than 1 month
  • October 4, 2019

For Birth Control "I’ve only been on Isibloom for 8 days. I’m taking it for acne more than I am for actual birth control. The reason why I’m writing this is because in just a few days my mood swings have been INSANE. I have gotten this random anxiety that feels very intense and scary. I normally do not get anxiety or mood swings like this at all, but I get these sudden rushes of rage and depression causing me to sob uncontrollably and act hysterical. I’m scared of how this may affect my life if I continue, because it’s causing me to feel depressed after each moody episode. I’ll continue taking it until the end of the month because I desperately want to clear my acne, but if it’s not 100% clear skin by then I will definitely switch brands."

5 / 10
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  • wel...
  • December 16, 2020

For Birth Control "I used Isibloom for 3 years. I initially got prescribed it at age 16 for hormonal cystic acne, and it immediately perfected my skin. I have not had cystic acne since, and I rarely get pimples. It was great at lightening and regulating my periods to the Wednesday of the placebo week. I did gain weight, but I believe this is not due to the medication and more so to just my body changing for the better over time (I was really skinny, 120 lbs, 5’8 when I started it). The reason I went off it was that I have anxiety, and remembering to take a pill every day was not good for my mental health. My body also did not respond well to the sudden decrease in hormones during the placebo week (I would become very depressed, bloated, and increased anxiety). But again, I did have an anxiety disorder prior to starting this. I switched to Nexplanon, and so far, it has been a lot better for me. But Isibloom is an AMAZING birth control for someone who is alright with taking a pill every day to prevent pregnancy."

9 / 10
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  • Bri...
  • Taken for 1 to 6 months
  • December 8, 2021

For Birth Control "The first couple of weeks were fine. A little increase in anxiety, but manageable. Week 3, I started being moody and just not feeling myself. Feeling nothing at all sometimes, or intense anxiety and/or depression. I figured it was just because my period was coming, but it came and went, and I feel the same. The anxiety can get so bad that I am having panic attacks, which I have not had in YEARS. I am NOT an emotional person, but I can cry in an instant now. I was on my phone laughing at something and then immediately started crying. I have cried more in the past 2 weeks than I have in 6 months, and I just feel like I’m going crazy. It has lightened my cycle and shortened it. I got a lot more cramping than with my normal period, though."

3 / 10
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  • Mar...
  • Taken for 6 months to 1 year
  • March 4, 2020

For Birth Control "So I've been on this birth control for 7 months now. It has been awful. I have had nonstop nausea, vomiting, extreme bloating, and mood swings that are horrible. I have also had severe depression and feel constantly sick. Went to the doctor finally. These pills have literally sucked the life out of me. Everyone is different, but I am going to stop taking these, they are horrible for your body. It does its job of preventing pregnancy, but the overall side effects are horrendous."

2 / 10
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  • Gui...
  • June 27, 2021

For Birth Control "I have been on Isibloom since around October of 2019 (a year and 8 months). I got prescribed the pill through the Pill Clubs online service. My first year was phenomenal! However, around November of 2020, I started having terrible constant nausea. I took several pregnancy tests that all came out negative. Around the same time, my depression became a lot worse, my anxiety was through the roof, everything made me cry, I had a never-ending yeast infection, and I lost all my libido (+ intercourse became painful and uncomfortable). Last week, I stopped my birth control to let my period come (it’s been a few months) and all of a sudden I feel like myself. My libido is back, I no longer feel bloated or nauseous, and my mood swings evened out. My period ended 6 days ago, and I’ve been back on the pill, I’m back to feeling completely terrible! Tonight I’m extremely nauseous and can’t even sleep. I’m going to stop taking it!"

4 / 10
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  • Spo...
  • Taken for 1 to 6 months
  • January 14, 2020

For Birth Control "So I have been on birth control since I was 18. I am now 26. I was on only prescription birth control pills for 7 years. When my last prescription ran out and my family doctor had a 3-month wait, I decided to use the pill club.com, they prescribed me Isibloom. I took it for 1 month and 2 weeks. Let me tell you, if you haven’t already started your pack, DO NOT TAKE THE PILLS. My experience on the 2nd week of taking them was awful. For the 1st month, I was nauseous for weeks! I couldn’t get myself out of bed because it made me so depressed. I only dragged myself out of bed when I had to go to work, and on my days off, I was in bed just restless and so emotional. When I was at work, I had moments I would just cry over the littlest things, and when I was at home with my bf, I would act so bipolar and argue over anything and everything! So now I stopped taking the pills for 3 days, and I am back to feeling normal. DO NOT TAKE THIS BRAND. DO NOT ORDER THEM ONLINE."

2 / 10
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  • Jor...
  • Taken for less than 1 month
  • July 2, 2018

For Birth Control "I was on Quasense for five years, starting when I was 14. I should’ve switched a long time ago. It gave me horrible nausea every time I started a new pack, to the point where I started to stop eating the night I took the first pill along with a nausea pill. It gave me acne, weight gain, and depression. It did NOTHING for my abnormally heavy and painful periods. I switched to Isibloom only a week ago, but I already love it. No nausea, I’ve lost 2 pounds and gained a cup size. I’m giving it a 9 because I haven’t been on it long enough to see what it does for my acne or for my periods!"

9 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • May 11, 2021

For Birth Control "I cannot believe the side effects I’ve had on Isibloom. I’ve taken this for about 1 month now. I have never had this bad of depression and anxiety in my entire life. My boyfriend tells me I act different, I feel like I act different. I am an emotional wreck! Listen to your body. I’m quitting tonight, not worth it."

1 / 10
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  • Nic...
  • Taken for 1 to 6 months
  • May 25, 2020

For Birth Control "At first, I was terrified to start taking Isibloom birth control due to all of the horrible reviews I read. However, it is working pretty well for me. It cleared up my acne, I have no weight gain, and I also don’t see any depression side effects. I was nauseous the first few days taking it, but I’m pretty sure that was just my body reacting to something so new. I’ve also been on it for six months."

8 / 10
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  • BEW...
  • January 15, 2020

For Birth Control "I started this BC 3 months ago after losing insurance, it was cheaper than the NuvaRing. After finishing my 3rd pack of hormonal pills, I started having withdrawal symptoms (jaw pain, shaking, hot flashes, heart palpitations, anxiety, depression, panic attacks, extreme mood swings). These symptoms lasted for 1 week straight, 24 hr/day. I wasn't feeling like myself, and I took myself to the ER 2x in 24 hours due to side effects. You know it was bad when I went to the ER 2x with NO INSURANCE! After my placebo week, I started back on the NuvaRing and feel 100x better and like myself again. I was prescribed anxiety medication to help me through this awful week. I've never had anxiety or depression before, or heart palpitations. I'm having a heart monitor put on for a month when I get health insurance to ensure that I'm no longer experiencing heart rates of 90-175 EVERY DAY. Figured out this medicine is double the dosage of hormones compared to the NuvaRing. This explains withdrawal symptoms. Beware."

1 / 10
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  • Jos...
  • Taken for 1 to 2 years
  • February 26, 2023

For Birth Control "I (20 yr) was on Isibloom for 2 years. It cleared my acne and lightened my periods, but I didn't realize until I got off how depressed I was. I was just always constantly a little sad. Now that I'm off, I have forgotten how good life can feel, though my acne has made a horrible comeback."

3 / 10
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  • Vid...
  • June 2, 2021

For Birth Control "I was really excited to start taking birth control. I was almost 19, in a relationship, and wanted to be safe. Plus, there were other benefits to taking birth control, such as lighter, regular periods and improvement in acne. When I first started taking Isibloom, I felt myself getting nauseous sometimes and cramps in my pelvic area. About a week after I started, I had gotten a cramping feeling in both of my calves, so I had to take ultrasounds to make sure there was no clotting. Nothing there, and I continued to use it. I noticed myself getting more sensitive and very irritable, but I figured it was a side effect. I would get sad for no reason. I would get really anxious sometimes. I disconnected with a lot around me. I didn’t have the energy that I did pre-birth control, and I definitely did not feel like myself. It progressively got worse, and my mental health was bad. Everyone’s experience is different. I stopped the birth control a week ago, and now I feel more like myself!"

3 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • May 14, 2019

For Birth Control "I was switched from Cyred to Isibloom, and TBH, I hate it. I’ve been having really intense mood swings/depression. I feel like a different person. I have no motivation to do anything and have had a noticeable loss of interest in my hobbies and even just going out to see friends. I also have been experiencing fatigue. I’m soooo tired all the time. I’ve been having to take 2-5 hour naps in the middle of the day."

2 / 10
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  • Anonymous
  • Taken for less than 1 month
  • June 6, 2019

For Birth Control "I haven't even been taking this pill for two weeks. In this time, I am having extreme trouble sleeping (even with the help of sleep aid pills), back pain, horrible cramping, and not to mention mood swings. I have been extremely irritated. I will be fine one minute, then start crying for absolutely no reason. I have no desire to be on a medication that completely alters my personality. This kind of depression is not okay, and in my opinion, not worth it."

2 / 10
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  • Dez...
  • Taken for 1 to 6 months
  • July 13, 2019

For Birth Control "This pill Isibloom started out great with little to no side effects and seemingly does its job considering I’m not pregnant. However, after 3 months, I began to experience severe mood swings. I cry all the time over little things and sometimes nothing. I also get uncontrollably angry and lash out on everyone. I have no motivation and I’m depressed most of the time. Some other side effects I’ve noticed were painful periods, nausea (to the point that I actually fainted), weight gain, and bloating. This pill is not worth taking, it greatly affected my mental health. After today, I will no longer be taking Isibloom. I absolutely DO NOT recommend."

2 / 10
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  • Sug...
  • September 30, 2019

For Birth Control "Everyone's bodies will react differently, so keep that in mind while you're reading through these reviews. I've been taking this for 2 months now, about to start my third pack. My first month wasn't bad, I practically had no side effects. I cried a couple of times, but I was also going through a lot of changes in my life at that time, so I have no idea if the pills amplified my emotions or not. The second month was pretty horrible. I had really bad nausea that I've never experienced before. I would be sitting there, and I'd constantly feel like throwing up. That eventually went away, but then the sadness/mood swings came back. Again, I don't know if I can blame the pills because I do struggle with mental health, but I feel like it amplified that sadness. It was more like once a week. But now that I'm starting my third pack, it hasn't been as bad. In summary, I experienced some nasty side effects, but they weren't every day, and they didn't last too long."

8 / 10
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  • Dix...
  • Taken for 6 months to 1 year
  • June 9, 2019

For Birth Control "I was originally taking Cyred EQ. Then, for some odd reason I don't know, my birth control provider switched me to one of the generics, Isibloom. At first, it wasn't bad. It made my skin clearer. I never got pregnant. It didn't really affect my sex drive. But on Cyred EQ, it let me skip my periods by not taking the placebo. I still got my periods once in a while. They weren't painful but annoying. You miss just one pill on Isibloom and BAM! Period. And I developed some of the NASTIEST mood swings. I could be in the best mood ever, and the next second, something so small would set me off. I'd get unreasonably angry and aggressive, and I would start to scream at people. Even at loved ones, like my mom. It gave me really bad depression. I'd get upset and cry over little things. Once in a while, I would have really depressed dark thoughts. I just took my last pill tonight and I'm throwing the rest away. I'm done."

3 / 10
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  • Coc...
  • Taken for 1 to 6 months
  • October 7, 2021

For Birth Control "I switched to this from Sprintec, hoping that it would be better in terms of helping my sex drive because I have absolutely none, but this made it even worse. It made me not even want to be touched, hugged, or kissed by my husband. It is ruining my marriage, and I am going to switch to something else ASAP. I’ve taken it for 3 months, and it’s been awful every single day. I feel like I’m going crazy. It has given me severe nausea and headaches EVERY SINGLE DAY, no joke, no exaggeration. I have not been able to get rid of the headache since I started it. I have been taking ibuprofen, Tylenol, and Excedrin like it’s all M&Ms or something. I am miserable. It has made my anxiety and depression 10x worse than what it was. I was doing really well before starting this, and now I feel like I’ve taken 100 steps back and have to repeat the process all over again. It has given me extreme insomnia. I haven’t slept more than 5 hours each night since taking this. Do not recommend."

1 / 10
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  • Ang...
  • December 16, 2020

For Birth Control "I started taking Isibloom in June 2019, the first month or two was horrible for mood swings, etc. Mainly PMS symptoms. It took me about 6 to 9 months of being on it for my periods to not come every month. I don't do the green pills in the pack, I just keep going with the orange pills. I'm now at the point where I just get my period every 2 to 3 months. I have not gained weight from what I can tell. Also, I haven't had any effects with acne, if anything, my skin might be clearer? The bad side effects of this, though, is that I believe it has made me a lot more depressed and anxious. I tend to be more sensitive to things people say and cry more often. Also, beware it might get rid of your sex drive. I used to have a very high sex drive, and then when I went on Isibloom, it's like nothing arouses me and, to put it frankly, I'm never horny anymore. I may switch to an IUD, but I've heard those are even worse. For now, though, I will stick with Isibloom."

7 / 10
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  • KJa...
  • Taken for less than 1 month
  • May 2, 2019

For Birth Control "Isibloom made me very depressed, and I only used it for two weeks. I felt the need to cry about everything and have just been overwhelmingly sad. It also made my boobs extremely tender and my vagina very sensitive to where, if I wiped, it would hurt. This is ridiculous."

1 / 10
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  • Roz...
  • Taken for 1 to 2 years
  • April 30, 2019

For Birth Control "Horrible little pill (Isibloom)... I have zero desire to have sex, or even kiss my partner. It is causing a major rift in our relationship. I have been irritable to the extreme and more depressed than ever before. I feel completely unmotivated, worthless, and hopeless. Breast tenderness is just a minute detail compared to the others, but another side effect worth mentioning. Any pill that cancels out your desire to live is not worth taking. Oh, and this pill is somehow linked to brown sun spots forming on my face (melasma). I'm so done with Isibloom."

1 / 10
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  • Roz...
  • Taken for 1 to 2 years
  • April 30, 2019

For Birth Control "Horrible little pill (Isibloom)... I have zero desire to have sex, or even kiss my partner. It is causing a major rift in our relationship. I have been irritable to the extreme and more depressed than ever before. I feel completely unmotivated, worthless, and hopeless. Breast tenderness is just a minute detail compared to the others, but another side effect worth mentioning. Any pill that cancels out your desire to live is not worth taking. Oh, and this pill is somehow linked to brown sun spots forming on my face (melasma). I'm so done with Isibloom."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.