Denosumab and Pain: What Users Say (Page 3)

• Rob...
• Taken for 1 to 6 months
• May 15, 2023

For Osteoporosis "My first injection of Prolia was on January 26, 2023, and it will be my last! Within 1 day of the injection until now (May 14, 2023), I experienced severe body pain, including hip, thigh, groin, swollen knees, severe muscle twitching, blurred vision, hair loss, and the list goes on. So far, I have not experienced ONJ (jaw bone disease). DO NOT USE! I did not research this drug, nor was I informed of the side effects by my doctor. Also, you can't just quit Prolia! You have to relay off with another bisphosphonate in order to not have PROBABLE, not possible, spinal compression fractures!! I will be using IV Reclast as my relay drug."

• Rob...
• Taken for 1 to 6 months
• May 15, 2023

For Osteoporosis "My first injection of Prolia was on January 26, 2023, and it will be my last! Within 1 day of the injection until now (May 14, 2023), I experienced severe body pain, including hip, thigh, groin, swollen knees, severe muscle twitching, blurred vision, hair loss, and the list goes on. So far, I have not experienced ONJ (jaw bone disease). DO NOT USE! I did not research this drug, nor was I informed of the side effects by my doctor. Also, you can't just quit Prolia! You have to relay off with another bisphosphonate in order to not have PROBABLE, not possible, spinal compression fractures!! I will be using IV Reclast as my relay drug."

• Rob...
• Taken for 1 to 6 months
• May 15, 2023

For Osteoporosis "My first injection of Prolia was on January 26, 2023, and it will be my last! Within 1 day of the injection until now (May 14, 2023), I experienced severe body pain, including hip, thigh, groin, swollen knees, severe muscle twitching, blurred vision, hair loss, and the list goes on. So far, I have not experienced ONJ (jaw bone disease). DO NOT USE! I did not research this drug, nor was I informed of the side effects by my doctor. Also, you can't just quit Prolia! You have to relay off with another bisphosphonate in order to not have PROBABLE, not possible, spinal compression fractures!! I will be using IV Reclast as my relay drug."

• G10...
• July 20, 2016

For Osteoporosis "1 shot, due another in August and wondering. Constipation very severe, fatigue, hip pain, upper arm pain and shooting pains in head. I do not know if there are other options available and scared to take second shot in case things get worse."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Cat...
• Taken for 2 to 5 years
• April 29, 2019

For Osteoporosis "I have had 6 Prolia injections. With the first 5 injections, I had muscle pain for a few weeks. This was relieved with ibuprofen. I had my 6th injection in February 2019. One week after the injection, I started experiencing severe hip pain. As the days went on, the pain appeared in my shoulders, hands, feet, ankles, knees, and elbows. The pain is so severe I am having trouble walking. It takes me a minimum of 30 minutes to get out of bed. I have been back to my doctor twice, and she says there is nothing she can do but prescribe pain medication. She said it will take 6 months for the medication to wear off. I have read comments from some saying even after 6 months, the pain does not go away. I have read comments from others saying they have not experienced side effects. You are not safe. Stop taking this drug now. Before this drug, I was a healthy, active woman."

• Nom...
• Taken for 1 to 6 months
• September 7, 2019

For Osteoporosis "After one treatment, severe jaw and hip pain, rashes, and my hair has started falling out. I wasn't told by my doctor that I couldn't stop this medication without risking spinal fractures. This drug shouldn't be on the market. I only gave it a one because 0 wasn't an option."

• Dag...
• Taken for 6 months to 1 year
• June 6, 2019

For Osteoporosis "In May 2018, I had my 1st Prolia injection for mild bone loss. After that, I just had occasional hip pain. Two weeks after my 2nd injection in November 2018, my doctor sent me for physical therapy because of severe lower back pain. The pain moved from the lower back to my thighs. I received a steroid shot into my lower spine without relief. 2 months ago, I underwent arthroscopic spine surgery to clean up discs and remove a bone spur. While my back healed, the back and leg pains persisted. Walking, especially stairs, has become challenging, where I used to walk 3 miles daily, I can now barely walk around the block. My left leg has weakened. Back to physical therapy. According to my surgeon, I should be able to do routine housework, yard work, walking, and other low-level activities without pain. I truly hope that with time, Advil, and a positive outlook, the severity of the pain will lessen, and I can enjoy life again. One thing I know for sure: I will not be getting another injection of Prolia."

• Dag...
• Taken for 6 months to 1 year
• June 6, 2019

For Osteoporosis "In May 2018, I had my 1st Prolia injection for mild bone loss. After that, I just had occasional hip pain. Two weeks after my 2nd injection in November 2018, my doctor sent me for physical therapy because of severe lower back pain. The pain moved from the lower back to my thighs. I received a steroid shot into my lower spine without relief. 2 months ago, I underwent arthroscopic spine surgery to clean up discs and remove a bone spur. While my back healed, the back and leg pains persisted. Walking, especially stairs, has become challenging, where I used to walk 3 miles daily, I can now barely walk around the block. My left leg has weakened. Back to physical therapy. According to my surgeon, I should be able to do routine housework, yard work, walking, and other low-level activities without pain. I truly hope that with time, Advil, and a positive outlook, the severity of the pain will lessen, and I can enjoy life again. One thing I know for sure: I will not be getting another injection of Prolia."

• Tri...
• Taken for 6 months to 1 year
• September 23, 2019

For Osteoporosis "I had my 2nd Prolia injection two months ago, the second stage of a two-year research study. Five days ago I woke up with the worst pain of my life, starting in my hip and extending down my leg. Until now, I have been a very active 66-year-old, with absolutely no health problems. Oh, how I wish I had never signed on to the study. The osteoporosis that made me eligible to participate was minimal; this pain is atrocious. I trusted the doctor heading the research to, first of all, do no harm. She apparently did not deserve that trust. She did not warn me that I could suffer serious debilitation as a result of Prolia, even after I spoke of a new, nagging hip pain that started after the first injection."

• mus...
• Taken for 5 to 10 years
• October 5, 2019

For Osteoporosis "I was diagnosed with fibro (Epstein Barr) 20+ years ago, so a lot of the side effects from Prolia, I blamed on that. I have been getting more severe pain (shoulder, arm, wrist, fingers, femur, knees, feet, etc. - you get the picture). I was in so much pain before the last injection, but was warned about the consequences by the PCP and Endro docs, waited an extra month and felt great so went ahead and had another injection of Prolia. I am 4 months in on that and in so much pain I can hardly function. The docs all act like it is worth taking. Boy, they must be getting a bundle from big Pharma!! #NOMOREPROLIA"

• sde...
• Taken for 1 to 6 months
• June 18, 2021

For Osteoporosis "After one injection in April 2021, I have been miserable! My hair is coming out in clumps (I am so depressed), I have muscle aches, night sweats, jaw pain, and headaches. I feel like a bone on the outside of my foot broke just from walking. I will never take another Prolia injection! I feel like I’m on my own with medical care, as I have lost confidence in my doctor after this horrible experience!"

• Ach...
• December 9, 2019

For Osteoporosis "I have all the side effect symptoms of what Prolia can cause as written in Amgen's literature. I have had tests to check if there are any other health problems, and have discussed at length with my GP. I did contact Amgen to ask if I stop the Prolia injections, will the aches and pains cease, and how long will it take. The person I spoke to said he would pass on my questions, and they would contact me. BUT alas, NO REPLY (the contact I made was six weeks ago), and you guessed, I am NOT impressed."

• Ter...
• January 28, 2017

For Osteoporosis "I love the twice a year shot. The company is awesome and very helpful. But... 1st shot no side effects, 2nd shot left groin pain for about a week, 3rd shot and now right-sided groin pain since October that goes to my thigh, hip, and pelvic bone. Pain is severe at times. Also, thyroid problem is worse (not sure if related) and right side lower back pain. I can no longer take the medication."

• Ter...
• January 28, 2017

For Osteoporosis "I love the twice a year shot. The company is awesome and very helpful. But... 1st shot no side effects, 2nd shot left groin pain for about a week, 3rd shot and now right-sided groin pain since October that goes to my thigh, hip, and pelvic bone. Pain is severe at times. Also, thyroid problem is worse (not sure if related) and right side lower back pain. I can no longer take the medication."

• sal...
• Taken for 1 to 6 months
• September 22, 2018

For Osteoporosis "Received my second shot of Prolia one month ago. Within a week, I experienced thigh pain during the night. Pain has increased to the point of making it difficult to bend my leg during the night without experiencing terrible pain from my knee to groin area. Once on my feet, pain lessens but is a constant. Woke this morning to the same pain, but also pain in my upper arms and back as well. When I called my doctor - as suggested in the brochure - his response was to make an appointment with an orthopedist as it did not likely have anything to do with the medication. I am a healthy active woman who walks daily and maintains my own home. Don't know what is more frustrating - the pain or his response! After reading the comments by others, my symptoms are not unique. I will most likely discontinue this medication. Should also add, I am not taking any other medication."

• sal...
• Taken for 1 to 6 months
• September 22, 2018

For Osteoporosis "Received my second shot of Prolia one month ago. Within a week, I experienced thigh pain during the night. Pain has increased to the point of making it difficult to bend my leg during the night without experiencing terrible pain from my knee to groin area. Once on my feet, pain lessens but is a constant. Woke this morning to the same pain, but also pain in my upper arms and back as well. When I called my doctor - as suggested in the brochure - his response was to make an appointment with an orthopedist as it did not likely have anything to do with the medication. I am a healthy active woman who walks daily and maintains my own home. Don't know what is more frustrating - the pain or his response! After reading the comments by others, my symptoms are not unique. I will most likely discontinue this medication. Should also add, I am not taking any other medication."

• Ste...
• Taken for 1 to 2 years
• June 15, 2019

For Osteoporosis "I’m on my third round of Prolia. First round, I had no side effects. Second round, pain in hips and jaw on both sides of hip and jaw. Spoke to a nurse and was told they did not have any negative feedback to date. Third round, hip pain is present and now bone pain in left arm. The bone pain in all three locations is aching bone pain. It gets your attention. I’m just turning 50, not overweight, have osteoporosis on a low level. I’m now deciding I need to find an alternative. It is difficult to determine what is the Prolia side effects and other aspects of aging and some fibromyalgia that I have but I do feel, after reading other's experience, Prolia is causing further pain that was nonexistent prior to the shots."

• Ste...
• Taken for 1 to 2 years
• June 15, 2019

For Osteoporosis "I’m on my third round of Prolia. First round, I had no side effects. Second round, pain in hips and jaw on both sides of hip and jaw. Spoke to a nurse and was told they did not have any negative feedback to date. Third round, hip pain is present and now bone pain in left arm. The bone pain in all three locations is aching bone pain. It gets your attention. I’m just turning 50, not overweight, have osteoporosis on a low level. I’m now deciding I need to find an alternative. It is difficult to determine what is the Prolia side effects and other aspects of aging and some fibromyalgia that I have but I do feel, after reading other's experience, Prolia is causing further pain that was nonexistent prior to the shots."

• Jus...
• Taken for 1 to 6 months
• October 24, 2019

For Osteoporosis "I took my first shot of Prolia in July 2019. I sure wished that I had seen this site prior to taking the shot. I had just trusted my GP and did not do any research. My legs are so weak and I have so much pain in my legs that I am finding it difficult to do anything. I work for 5 minutes and then rest for 5 minutes. I have already told my GP that I will not take any more shots. I am praying that my legs will eventually heal as I have always been active, and now I hurt so much that I just can't do what I normally do."

• CFa...
• Taken for 1 to 6 months
• November 30, 2019

For Osteoporosis "I started to have muscular pain within a week, which increased to the point of pain at rest enough to disturb my sleep. It is now six months since I had the injection, and the pain has decreased over the past month. I won’t have it again as it doesn’t agree with my body for some reason. However, my friend has been having it for some time with no ill effect and an actual increase in bone density. We are both in our mid-sixties."

• san...
• Taken for 1 to 6 months
• September 11, 2018

For Osteoporosis "I was fine on July 5, 2018, at my RA doctor's check. I had no pain. I got the Prolia shot and was in excruciating pain at a level 10 in less than 12 hours. It has been 2 months, and I am still experiencing severe effects. I haven't been the same since. I called the doctor 4 times, went in, and received two steroid shots in my shoulders, but they are denying it could be from the Prolia shot."