Denosumab and Pain: What Users Say (Page 2)

• Jan...
• Taken for 1 to 6 months
• May 20, 2023

For Osteoporosis "I have found my back pain is worse than ever, my immune system has declined, my cholesterol went way up, I developed a skin rash, and I still have a lack of appetite, muscle pain, headaches, nausea, swelling, jaw pain, chills, mouth and legs tingling, pain in my arms, sore throat, trouble sleeping, and more pain. I do not recommend the Prolia injection. It is bad, bad, bad, you start feeling miserable because the pain is unbearable."

• Lay...
• July 28, 2016

For Osteoporosis "After two shots, I had swelling in both elbows, a stiff neck, and pain. I am not sure if Prolia is the cause, but I will not risk it again or any drugs for osteoporosis. My immune system was compromised, and I have had several illnesses. I went from an active, fit person to not being able to perform simple everyday tasks without significant pain. I have had the worst 6 months of my life. Avoid this medication!"

• Ver...
• Taken for 1 to 6 months
• January 20, 2020

For Osteoporosis "My GP recommended I have the Prolia injection for my bone density. I read about the side effects but hadn’t seen this website, so went ahead on 5 Nov 2019. Within 24 hours, I experienced terrible pain in my left arm. The pain was in the bone. This occurred two days running before it subsided. I saw my GP two days later and told her of the pain and I said never again will I have this injection. She agreed. The pain went away but other symptoms attacked me. Extreme irritability, lethargy, bloating, loss of appetite. I visited my GP twice about the side effects. The second time (10 days ago), she recommended a strong probiotic. I took it and in two days the bloating had gone and my appetite began to return. The Prolia drug had attacked the good bacteria in my gut. After 10 days on the probiotic, I feel normal again. Three months and two weeks later, and it is out of my system."

• fir...
• February 6, 2017

For Osteoporosis "I received two Prolia shots because I was prescribed Femara after breast cancer. Prolia was supposed to offset the bone loss caused by Femara. I had a lot of pain in my muscles and bones after the first injection but thought I would get used to it. After the 2nd injection, I could hardly walk. It has been 7 months since the injection, and if anything, the pain is debilitating. I can't walk without a walker or cane, cannot turn over in bed at night. As far as the bone loss, I have no idea if it helped, but one thing I do know, I will never take another injection of Prolia. I would prefer the bone loss to the constant pain. I believe if I took the 3rd, I would die. I was a very active 71-year-old, mowed the yard, trimmed bushes, NOT NOW."

• BJa...
• Taken for 1 to 6 months
• December 26, 2019

For Osteoporosis "I am a 76-year-old female. First shot of Prolia on Nov 1, 2019. Side effects started after 3 days. I have always had very low BP. I felt so bad for 2 weeks, someone took my BP and it was very high. Other side effects include joint, shoulder, neck, and knee pain. Day and night sweats are very severe. My side effects aren't nearly as bad as some, so I shouldn't complain. Will not get a second shot."

• BJa...
• Taken for 1 to 6 months
• December 26, 2019

For Osteoporosis "I am a 76-year-old female. First shot of Prolia on Nov 1, 2019. Side effects started after 3 days. I have always had very low BP. I felt so bad for 2 weeks, someone took my BP and it was very high. Other side effects include joint, shoulder, neck, and knee pain. Day and night sweats are very severe. My side effects aren't nearly as bad as some, so I shouldn't complain. Will not get a second shot."

• Sto...
• Taken for 2 to 5 years
• February 16, 2021

For Osteoporosis "Had my fifth shot of Prolia on December 8th, 2020. Will definitely not be taking this drug again. I found that with each passing injection, the symptoms became more severe. I have gone from being a very fit person to being totally disabled. Muscle weakness in thigh muscles and arms. Extreme pain in shoulders and arms. Very tight rib cage muscles. No energy. Extreme nausea. Discomfort in my throat. Dry cough at night. Muscle stiffness, twitching, cramps, and spasms. Severe right hip pain and sciatica pain. All of these started after taking Prolia."

• M H...
• Taken for 1 to 2 years
• April 17, 2016

For Osteoporosis "Prolia shot given July 26, 2012! Immediately had every dermatological problem listed in the ad: Itching, rash all over body except for face, extreme pain, dry skin, repeated biopsies, thousands of dollars for doctors, prescriptions, lotions, and potions. Left calf's skin completely peeled off like the bark of a tree and has never recovered four years later!! Even now it is again broken out in oozing rashes around the ankle, but the entire leg hurts. I must keep the hair on my legs shaved very close or when I am exercising in the Y pool, the leg is painful just with the movement of the tiny hairs in the water. The pain is inside as well as on the surface of my skin. These bad side effects continue! Have pictures of early rash available."

• sha...
• March 11, 2017

For Osteoporosis "My mom got this shot a month ago and her life has been hell. Extreme pain that she ended up in the hospital getting injections for pain and on morphine. Extreme headaches to where she cannot function, along with godawful headaches. Jaw pain, muscle cramps, fevers, stomach issues, bladder issues, short-term memory issues, and with all this happening she is now depressed from all the issues which now gives her anxiety wondering if these will go away or not. The sad thing is that not all the symptoms show up right after the shot. They show up weeks later and no one can tell you how long they will last."

• sha...
• March 11, 2017

For Osteoporosis "My mom got this shot a month ago and her life has been hell. Extreme pain that she ended up in the hospital getting injections for pain and on morphine. Extreme headaches to where she cannot function, along with godawful headaches. Jaw pain, muscle cramps, fevers, stomach issues, bladder issues, short-term memory issues, and with all this happening she is now depressed from all the issues which now gives her anxiety wondering if these will go away or not. The sad thing is that not all the symptoms show up right after the shot. They show up weeks later and no one can tell you how long they will last."

• Lak...
• Taken for 1 to 2 years
• July 10, 2016

For Osteoporosis "Various side effects including fractures in both feet and bad pain and aching in right leg making it almost impossible to walk and keeping me awake and in pain. It is time for my third Prolia shot and I have suffered from this for two months and am no better. This has not been a positive experience but a bad and painful one leaving me unable to get out and perform any daily tasks or functions."

• Lac...
• November 24, 2019

For Osteoporosis "I’m so sorry I ever took Prolia shots. After 4 injections, I am in constant terrible pain. I am 66 years old and was so healthy and mobile before the Prolia. Now, leg, hip, arm, and jaw pain. Barely walking now. Taking physical therapy but no relief. This drug should NOT be on the market!! Does anyone know if, after discontinuing the Prolia, this stuff ever leaves our bodies?"

• Til...
• May 30, 2017

For Osteoporosis "Three days after receiving my first Prolia injection, I developed a cough which turned into bronchitis and was treated with antibiotics - bad luck, a coincidence I thought. A month later, my life changed with severe bone pain in my right jaw. I had lockjaw five times. Pain in my right shoulder, ribs, and my neck was so stiff, but worse was my lack of mobility. My morning walk to the bathroom was just like watching Frankenstein walk, I couldn't move any faster because of the pain. Getting on and off the toilet was a major event. Turning in bed was excruciating and sometimes impossible. This lasted the whole summer of 2015, which eventually tapered off to where I am today. Worst experience of my life. No more Prolia for me."

• Jud...
• June 13, 2016

For Osteoporosis "I am having severe jaw pain, almost unbearable. It is one of the most horrible experiences I have ever gone through. Will not take this drug again. What is strange is that I didn't have a problem until after the second shot. Since then have not only teeth pain but sick with sore throat and cold. Also bad digestive problems."

• Bre...
• Taken for 6 months to 1 year
• January 2, 2021

For Osteoporosis "Had a wedge compression fracture in August 2019, doctor ordered Prolia injection. Wish I had never had it, developed stomach and intestinal problems, reflux (never had any problems with that before), pain in groin (a cyst on ovary was found), increased pain in neck, had an increase in blood pressure, pulse rate increased, pain in arms, legs, and continue with pain in back, muscle soreness, and weakness. Was diagnosed with Barrett's Esophagus in January 2020. Never will allow another injection, and of course, doctors don't believe it caused these problems."

• Bre...
• Taken for 6 months to 1 year
• January 2, 2021

For Osteoporosis "Had a wedge compression fracture in August 2019, doctor ordered Prolia injection. Wish I had never had it, developed stomach and intestinal problems, reflux (never had any problems with that before), pain in groin (a cyst on ovary was found), increased pain in neck, had an increase in blood pressure, pulse rate increased, pain in arms, legs, and continue with pain in back, muscle soreness, and weakness. Was diagnosed with Barrett's Esophagus in January 2020. Never will allow another injection, and of course, doctors don't believe it caused these problems."

• XGy...
• Taken for 1 to 6 months
• November 25, 2019

For Osteoporosis "This is now 1 year, 1 month from my one and only Prolia injection. Reading the other comments from patients who have had poor to terrible side effects, I am certain that one dose of Prolia likely still lingers in my system and the side effects continue. My bone and muscle pain kicked in with a vengeance and has not abated. Walking became and remains difficult due to body pain and loss of strength/balance/pain in addition to which, my skin rashes causing both pain and itching continue. I regret being talked into taking Prolia even though my osteoporosis remains seriously advanced. All of the side effects continue although I only had the first injection due to the severe reaction that kicked in within a few days. Note: Amgen is recently promoting a 'new' drug 'Evenity' ... an almost identical to Prolia... which has major warnings, actual black boxed warning - some even worse than the Prolia warnings. Doctors continue to advise trying the drug. For me, that is not an option."

• Slm...
• January 1, 2020

For Osteoporosis "I had one injection in 2018 and started having side effects the next day. Skin rash and itching, then mouth ulcers, swollen lips and tongue. Pain in feet, legs, and hip, and fatigue. I would never recommend nor have this drug again. It has been over a year, and I still have symptoms."

• Slm...
• January 1, 2020

For Osteoporosis "I had one injection in 2018 and started having side effects the next day. Skin rash and itching, then mouth ulcers, swollen lips and tongue. Pain in feet, legs, and hip, and fatigue. I would never recommend nor have this drug again. It has been over a year, and I still have symptoms."

• Slm...
• January 1, 2020

For Osteoporosis "I had one injection in 2018 and started having side effects the next day. Skin rash and itching, then mouth ulcers, swollen lips and tongue. Pain in feet, legs, and hip, and fatigue. I would never recommend nor have this drug again. It has been over a year, and I still have symptoms."

• Mar...
• Taken for 1 to 6 months
• May 26, 2016

For Osteoporosis "From the start, I began to experience side effects. The most bothersome are the extreme sweating episodes followed by chills at least 12 times a day or more. In addition, other side effects are more pain in my lower back and hips as well as a rash with associated itch on my upper back. I will never get another Prolia shot!!! Wish I knew there would be so much discomfort!"

• jdl...
• Taken for 5 to 10 years
• October 13, 2018

For Osteoporosis "I had been fighting osteoporosis for years when Prolia was suggested. I was on it for about six years. Then a change in doctors at the medical center caused a short delay. In a few weeks after that shot was due, I had three terrifically painful vertebral compression fractures. Now, eight months later, I'm a semi-invalid in the sense that I cannot be upright (sitting or standing) for more than an hour or two before the pain becomes more than I can bear. I was formerly very active; now my life is extremely confined. The more I learn about this drug, the worse I see that it is. My doctor and I have reported this to the FDA. Amgen has no advice as to how to get off safely. 'Ask your doctor,' they tell me. So far, the docs have been unable to show me a safe way to get off this horrible drug."

• Bac...
• Taken for less than 1 month
• July 12, 2019

For Osteoporosis "I found that after having one injection of Prolia, the side effects were worse than the possibility of maybe breaking a bone. I had muscle and joint pain, back pain, vertigo, hip pain, and just felt flu-ish for more than one month after the injection. I now have diarrhea. I will not be taking it again."

• Jas...
• Taken for 6 months to 1 year
• June 12, 2019

For Osteoporosis "I was on Boniva for 10 years with no improvement in my bones. My doctor switched me to Prolia shots. I took my first shot of Prolia in January 2018 and developed severe mouth ulcers, sloughing of my gums. I could not handle spice or salt, and my nutrition fell. At that time, I did not associate it with Prolia. I took my second shot in August, and my mouth ulcers flared up. Severe ulcers in the gums, upper palate, back of the throat, and nasopharynx area. My mouth had grey, purple, and white patches. I was unable to eat. I also developed severe jaw pain, bone pain, and muscle weakness. For three days, my low back, hips, and legs froze, and I was in excruciating pain and could not walk. I was in bed with ice packs and anti-inflammatories. I was frightened. I have stopped Prolia. It has been more than a year, and my mouth ulcers have not healed. I am now being treated at a university hospital. This is not a safe medicine and should not be prescribed."

• LSt...
• Taken for 2 to 5 years
• April 4, 2017

For Osteoporosis "I was diagnosed with osteo in 2010 and was put on Fosamax, along with a daily dose of calcium-VitD tablet. In 2014, the doctor changed my prescription to Prolia due to its stronger potency, along with the continued Cal-VitD tablet. Though my bone density increased 10% since taking Prolia, I feel the side effects may outweigh any positive bone density increases. With constant jaw pain, I also have unusual problems with my teeth: constant infections, pain in one tooth or another, and root canal treatments needed. I suffer from insomnia, something I never had pre-Prolia. With no warning or trigger, I have constant blood blisters in my mouth, some as big as 5 cent pieces. My cholesterol has increased. I feel unusually tired and have regular leg cramps."