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Prolia User Reviews & Ratings (Page 3)

Prolia has an average rating of 2.9 out of 10 from a total of 375 reviews on Drugs.com. 16% of reviewers reported a positive experience, while 76% reported a negative experience.

Reviews for Prolia

Commonly mentioned side effects
  • bad...
  • Taken for 2 to 5 years
  • June 19, 2023

For Osteoporosis "My mom had been on Prolia for 5 years with one year of missed doses in the middle of it due to Covid and the doctor retiring as well. In total, 8 doses. She had foot pain after the 7th dose and could barely walk, and also got sepsis after the 7th injection. She survived sepsis and got her 8th injection 2 months after her sepsis, and on the day of her 8th injection, she got a parotid infection within a couple of hours, and she passed away 2 weeks later. I believe the doctor never should have given her the last injection as she was in sepsis recovery. She had a very low immune system afterward. There's a black box warning not to give if on immunosuppressive medicine, but the warning should also include not to give if a low immune system from a recent severe infection. Also, a low rating as you can't just stop Prolia due to rebound fractures and have to go on a rebound drug until bone turnover is good."

1 / 10
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  • Ske...
  • Taken for 1 to 2 years
  • May 11, 2021

For Osteoporosis "I blame Prolia for my late wife's death. She died from cervical cancer at 72 even though she had a hysterectomy at 30. I think it lowered her immune system so much that she could not fight off the cancer. Even though the doctor knew she had a thyroidectomy at 31, she still administered the Prolia injections. I would urge everyone to stay away from it."

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  • Tup...
  • Taken for 6 months to 1 year
  • August 26, 2016

For Osteoporosis "I am in the UK and therefore am 'lucky enough' not to have paid for my treatment. However, I understand this is a relatively expensive drug for the National Health Service to prescribe. I have had two six-monthly doses, and I will certainly not be having the third despite having severe osteoporosis. I have experienced no positive results from this drug, only debilitating pain, stiffness, and general flu-like symptoms which come and go regularly day and night with no prior warning. My worst experience was a spot on my lower jaw bone that grew until it literally erupted, leaving a 2mm diameter hole in the side of my face. (2 months of antibiotics) I can find no positive feedback to justify this drug's side effects."

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Frequently asked questions

  • Pat...
  • June 30, 2019

For Osteoporosis "I was fine after the first shot of Prolia. However, after taking the second shot I almost immediately started experiencing side effects. Terrible pain in my hips, back, and legs. For some reason if I drive for more than 10 minutes, the pain becomes so severe that I have to pull over off the road and stand for a while. I told my doctor about these issues and how they began right after my second Prolia injection. She had an X-ray of my back and hips to look for fractures, but none were found. She said that Prolia builds bone! However, I have decided not to take another Prolia shot. In my opinion within 10 years there will be numerous lawsuits about this drug. Disgusting greedy pharmaceutical companies know about this drug!"

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  • Jan...
  • Taken for 1 to 2 years
  • April 8, 2016

For Osteoporosis "I will never have this shot again. It made my skin loose & wrinkled. Researchers don't have a clue if this helps bones or not. I can tell you I completely regret trying Prolia. And hate seeing Blythe Danner doing this commercial."

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  • M H...
  • Taken for 1 to 2 years
  • April 17, 2016

For Osteoporosis "Prolia shot given July 26, 2012! Immediately had every dermatological problem listed in the ad: Itching, rash all over body except for face, extreme pain, dry skin, repeated biopsies, thousands of dollars for doctors, prescriptions, lotions, and potions. Left calf's skin completely peeled off like the bark of a tree and has never recovered four years later!! Even now it is again broken out in oozing rashes around the ankle, but the entire leg hurts. I must keep the hair on my legs shaved very close or when I am exercising in the Y pool, the leg is painful just with the movement of the tiny hairs in the water. The pain is inside as well as on the surface of my skin. These bad side effects continue! Have pictures of early rash available."

1 / 10
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  • Jo ...
  • Taken for 6 months to 1 year
  • June 12, 2023

For Osteoporosis "I was a very fit 87-year-old lady, living independently, walking 2 km a day, etc., etc. Three weeks ago, I had a 6-month renewal Prolia injection. I am now a cripple, hardly able to walk. This is a dangerous drug."

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More FAQ

  • Win...
  • Taken for less than 1 month
  • June 26, 2019

For Osteoporosis "After refusing this for the past 2 years, I finally relented and had the shot about 2 weeks ago. I felt okay for the first 3 days, after that, I experienced severe headache with immense fatigue that lasted for 2 days. The headache passed but still much fatigue, muscle pain & burning in arms & legs, lower back pain, ankles & hips. I should have followed my instincts. I am 66, do have osteoporosis (supposed bones of an 80-year-old). I will not be continuing with this."

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  • Oh ...
  • May 1, 2016

For Osteoporosis "I have been on Prolia for approximately two years. Just this year ( my 5th injection) I did experience sore muscle/joint pain in my hips. About 4 months ago I developed dermatitis around the corners of my eyes, nose, mouth, and along both sides of my neck. I've never had allergies before. Also, I'm dealing with a feeling of deep exhaustion. I'm not sure whether this is due to Prolia. If my next bone density doesn't show marked increase, I will ask my physician for a change in med. One note--I faithfully exercise 3-4 times weekly with a trainer, take calcium, and eat green veggies and foods with calcium/D."

6 / 10
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  • Jud...
  • Taken for less than 1 month
  • February 14, 2017

For Osteoporosis "Had first Prolia shot 9 days ago and it has been debilitating. Will not get another! It is not worth the pain and discomfort. I have had major bladder problems, chills, fatigue, all the bones in my back ache, I can't sleep at night. I have to take Advil to relieve back pain or I can't function. Can't leave the house for long because of bladder issues. I called my Oncologist about possible bladder infection and was promptly advised that was not a side effect of Prolia even though bladder issues was listed as a possible serious side effect! I hope I don't have to suffer from this one shot as long as others have - it is truly life style restricting. I wish I had read these reviews before getting my 1st (and ONLY) shot."

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  • koa...
  • Taken for 1 to 2 years
  • May 15, 2023

For Osteoporosis "I did not correlate the sudden pain in my jaw, molar, neck, backbones, and joints to the Prolia injections till these symptoms were repeated whenever I got the Prolia injection. It feels as if my own bones are sucked out of me and replaced with Prolia. I went through three injections already, unfortunately. It seems that I can't go back to where I was before Prolia as the pain gets worse signaling to take the next injection. I never experienced this pain before Prolia. It makes you completely dependent on Prolia. The saddest part is the pain gets even worse after each injection. I would not recommend anyone go through this."

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  • Dia...
  • April 28, 2016

For Osteoporosis "This drug has been a nightmare. I have experienced unexplained bone pain in lower left leg and a breakout of bleeding gums and mouth sensitivity. I did not get any info from the prescribing endocrinologist except that it was a safe drug and that he had prescribed it to his mother! This has been a very expensive lesson in terms of dental costs and extremely detrimental to my health and well-being."

2 / 10
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  • San...
  • Taken for less than 1 month
  • January 25, 2020

For Osteoporosis "I am two weeks in from my first injection of Prolia. I am experiencing fatigue and generalised muscle ache/pain. I would not have accepted this drug if I had prior knowledge about the vague knowledge available regarding the length of time side effects last! The side effect may or may not improve, they may get worse or even create more problems. I do not intend to continue this treatment where the benefits appear to be outweighed by the deficits. I was an energetic, vibrant person, now requiring paracetamol to keep moving and off the couch! And this might be permanent?"

2 / 10
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  • fir...
  • February 6, 2017

For Osteoporosis "I received two Prolia shots because I was prescribed Femara after breast cancer. Prolia was supposed to offset the bone loss caused by Femara. I had a lot of pain in my muscles and bones after the first injection but thought I would get used to it. After the 2nd injection, I could hardly walk. It has been 7 months since the injection, and if anything, the pain is debilitating. I can't walk without a walker or cane, cannot turn over in bed at night. As far as the bone loss, I have no idea if it helped, but one thing I do know, I will never take another injection of Prolia. I would prefer the bone loss to the constant pain. I believe if I took the 3rd, I would die. I was a very active 71-year-old, mowed the yard, trimmed bushes, NOT NOW."

2 / 10
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  • Pat...
  • Taken for 1 to 6 months
  • April 7, 2016

For Osteoporosis "I had my first injection in Oct 2015 and am due again in April. Is the 2nd shot any better than the first one? I experienced flu-like symptoms the first couple of days, then constant constipation, acid reflux, extreme tiredness, and itching. My doctor informed me that I should not undergo any dental procedures while on this medication, such as a root canal. What other medications can be taken? Or is a natural approach the best way to go? Speaking to naturopaths, they suggest that these medications disrupt the entire immune system. They advise against injections."

3 / 10
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  • Pro...
  • May 30, 2016

For Osteoporosis "I did not know, nor was I given any information on this injection. About 1 month in, I experienced hair loss in places. Have a tingling around the lips. I felt very nauseous on and off out of the blue. Am very tired and just cannot get rid of chest infection/cough which just seems to be on loop... I think it's clearing up then it hits again. I will not get this injection again. Nothing is conclusive about the cause of what I am experiencing."

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  • Anonymous
  • November 14, 2015

For Osteoporosis "I had a shot 3 months ago and have pain in my leg, shoulder, toes, and fingers. I have flu-like symptoms off and on. This is a horrible drug, and I will not be taking it again."

2 / 10
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  • Han...
  • December 1, 2018

For Osteoporosis "My wife was scheduled to take a Prolia injection for osteoporosis, but after we both read lots of reviews, she cancelled her appointment. Thank you for this valuable insight into the risks and benefits. Now, we do not know where to go or what to do about her osteoporosis, but it is time for further research on these drugs. Taking a 'drug from hell' is certainly not the answer."

2 / 10
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  • sha...
  • March 11, 2017

For Osteoporosis "My mom got this shot a month ago and her life has been hell. Extreme pain that she ended up in the hospital getting injections for pain and on morphine. Extreme headaches to where she cannot function, along with godawful headaches. Jaw pain, muscle cramps, fevers, stomach issues, bladder issues, short-term memory issues, and with all this happening she is now depressed from all the issues which now gives her anxiety wondering if these will go away or not. The sad thing is that not all the symptoms show up right after the shot. They show up weeks later and no one can tell you how long they will last."

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  • Lak...
  • Taken for 1 to 2 years
  • July 10, 2016

For Osteoporosis "Various side effects including fractures in both feet and bad pain and aching in right leg making it almost impossible to walk and keeping me awake and in pain. It is time for my third Prolia shot and I have suffered from this for two months and am no better. This has not been a positive experience but a bad and painful one leaving me unable to get out and perform any daily tasks or functions."

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  • Jud...
  • June 13, 2016

For Osteoporosis "I am having severe jaw pain, almost unbearable. It is one of the most horrible experiences I have ever gone through. Will not take this drug again. What is strange is that I didn't have a problem until after the second shot. Since then have not only teeth pain but sick with sore throat and cold. Also bad digestive problems."

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  • Geo...
  • Taken for 1 to 2 years
  • November 18, 2016

For Osteoporosis "While the bone test indicated a slight improvement, I don't feel it is worth it. The first time I had the Prolia shot, I had no reaction. After the second shot, my hair began to fall out in bunches. It has continued to fall out, and it looks as though I will have to wear a wig. Has anyone else had this problem, and does it go away after the drug wears off? I will never take another dose of Prolia, and would not recommend it after reading all the negative posts on this site. It would seem that my problem is small compared to others."

5 / 10
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  • Mar...
  • Taken for 1 to 6 months
  • May 26, 2016

For Osteoporosis "From the start, I began to experience side effects. The most bothersome are the extreme sweating episodes followed by chills at least 12 times a day or more. In addition, other side effects are more pain in my lower back and hips as well as a rash with associated itch on my upper back. I will never get another Prolia shot!!! Wish I knew there would be so much discomfort!"

2 / 10
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  • Jud...
  • Taken for 1 to 6 months
  • June 7, 2023

For Osteoporosis "I had my first Prolia injection on April 5th, 2023. I was so hopeful it would help my bones. Instead, it made my life worse! I feel terrible. My bones hurt, I have pains in my body where I never had pain before. Muscle aches and cramps. I feel so tired all the time. I'm 80, but I am constantly on the go. I do most of our yard work, take care of the car, and our own home. It is a large home and takes a lot of time. I also am blessed to have a great husband and a cute dog who loves to take walks. I struggle taking care of all of it now. In May, I had a terrible bladder infection. Still not completely over it. I did research on Prolia but did not do enough. I finally got a sheet listing all the side effects. It's a whole page! It's then I started to put two and two together. I am NOT going to take another shot. It's not good for me. I am looking into other ways to improve my bones. Beware! Prolia is not good for you!"

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  • RNa...
  • Taken for 2 to 5 years
  • August 4, 2019

For Osteoporosis "Prior to Prolia, I completed bisphosphonate therapy initially for osteopenia which worsened to osteoporosis with a BMD of -2.9. I find Prolia to be an effective medication but with a price. Starting in March 2016, I received my shot with minor bone discomfort. Three months after my fourth shot in March 2018, I was diagnosed with cellulitis of my left arm. I continued on Prolia, as my BMD scores had improved to -2.6 and I had less back and hip pain. By September 2018, after 6 months of gastroenterology problems, I consulted a specialist. Completing a colonoscopy, I was diagnosed with microscopic lymphocytic colitis. Afraid to stop Prolia, as discontinuing this drug increases the risk of broken bones, including the spine. Recently, April 2019, I was diagnosed with Atrial Fibrillation. Strike three. Do not start this drug. I am an extremely active adult, biking and hiking, and now what do I do? My endocrinologist denies Prolia is the culprit."

6 / 10
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