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Prolia User Reviews & Ratings (Page 2)

Prolia has an average rating of 2.9 out of 10 from a total of 375 reviews on Drugs.com. 16% of reviewers reported a positive experience, while 76% reported a negative experience.

Reviews for Prolia

Commonly mentioned side effects
  • Dav...
  • February 2, 2020

For Osteoporosis "My mother stopped taking because her teeth started to fall out. Within a few months, her back broke and then it broke over the next year, broke a total of four times. I’ve read hundreds of similar stories, and a class action needs to be started to get this drug off the street and to collect damages for families. Let’s start putting together a pool of people."

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  • Suz...
  • Taken for 1 to 2 years
  • January 29, 2020

For Osteoporosis "I'm 71 years old. After two hip replacements, my orthopedic surgeon placed me on Prolia in the summer of 2017 in order to build bone density. Bone density was reversed and I was pleased. It's January 2020, and now the side effects are beginning. I'm feeling severe jaw bone pain. After an MRI of my jaw, it's determined I've lost bone density in my jaw, my gums are very sore, and now I'm being treated with laser surgery. My dental implants will need to be removed by the oral surgeon within 6 months. Ladies, what do we do now and Amgen...Where are you?"

3 / 10
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  • Poo...
  • October 28, 2015

For Osteoporosis "Prolia has the worst side effects of any medication on the market because it tampers with the immune system. I have had to call Amgen and the FDA numerous times for very serious side effects. This drug should be taken off of the market until medical doctors learn how to combat it. Once it's in, there is nothing they can do. In all reality, it is a chemo drug as its twin Xgeva just has more of the active ingredient in it."

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Frequently asked questions

  • LMa...
  • July 29, 2019

For Osteoporosis "I am a 45-year-old female with severe osteoporosis of the spine, osteopenia of the femur and hips. I took Prolia in September of last year and it will be the one and only time that I take it! I was sick within two months of taking this drug! I have been running a fever nonstop, terrible headaches, abdominal pain, nausea and vomiting, weakness in legs, joint pain, and rashes! This drug is so bad! My life has been turned upside down with this sickness from Prolia, numerous ER visits, doctor appointments, and missing work. I am a single mother who couldn’t afford any of this. PLEASE DO NOT TAKE THIS DRUG!"

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  • Anonymous
  • February 19, 2020

For Osteoporosis "I had 3 injections of Prolia in the last 2 years and really nothing that I have read has happened to me. Yesterday, I had my appointment with my oncologist, and she told me that after reviewing my bone density results, I don't need the 4th dose of Prolia. My bones are in excellent condition. I had no side effects at all."

10 / 10
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  • Nev...
  • July 20, 2019

For Osteoporosis "Had my first shot of Prolia on 4/4/2019 and will never have another one. Side effects started within 14 days: red hot blotches under my arms, on my hips night sweats, daytime chills, and pain that has impacted my life dramatically. All this started with a Bone Density Scan when turning 70, was told I had a high fracture risk and Prolia would help. I am very active, ran 10k a day until 6 years ago when I started having problems with osteoarthritis in my knees, stopped running, and took up walking 10k instead. However, since this injection, I have found it extremely difficult due to pain and fatigue. Please, if anyone is thinking of taking this poison, do not. Do your research when a doctor recommends a drug, go and research before taking it. Doctors do not mention side effects, and when you go back to see the doctor, you're an oddity because all their other patients on this drug do not have side effects."

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  • bba...
  • June 22, 2021

For Osteoporosis "I had my first injection in April 2021 and started having side effects right after-severe headaches, muscle pain, and dizziness. It has been 2 months now, and my bp has gone up, severe headaches, hip pain, and every muscle in my body aches. I was told by the doctor that this was unrelated to the Prolia. I had none of these until I had the injection. I will never take this again and be warned-this is a horrible drug and should be taken off the market. I suffer daily and do not know how long this horrible drug will stay in my body and give me side effects. I live in severe pain every day, and my doctor had to increase my pain meds. There are days I feel like I am never going to be the same person! Please read all about this horrible drug and do not listen to your doctor as it is horrible!"

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More FAQ

  • Ano...
  • Taken for 1 to 6 months
  • October 10, 2019

For Osteoporosis "First time I was asked about taking Prolia, I refused, having read all the side effects. My bone density test was a little better than the previous one 2 years prior. Wasn't warned about the cost that insurance didn't cover, even though I asked to be notified of my copay. My doctor talked me into it and I'm so sorry. Constipation was totally out of control even with medication for it. I started with the leg pain and hip pain waking me up at night! And all of a sudden, my dental health totally went down the tubes! Also, I had times of nausea for no reason. I have always had no trouble sleeping until the shot. Now that I have read extensively about the side effects, I am refusing it. Did I mention I was healthy, on no meds, and do weight exercises and cardio classes along with some yoga, and 76 years old. Hoping some of the side effects go away! So sorry I agreed to take this!"

2 / 10
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  • Gra...
  • Taken for 6 months to 1 year
  • June 27, 2016

For Osteoporosis "After getting my 2nd Prolia injection, I've had the worst 4 months of my life!! Within a couple of weeks, I went from a very young 70-year-old to a 90-year-old woman. My back and hips have been so painful that I have to wear a stiff back support to be able to move. Even with this, I can't stand up straight. I am awakened at night because of the pain, and I can't turn over in bed. I am constantly achy and tired. Before Prolia, I was extremely active. I worked with a personal trainer twice a week for six months, before the 2nd injection, but now, I have probably lost all the muscle, strength, and flexibility I gained. I put my gym membership on hold until I can move again without pain. Prolia is the worst!!"

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  • Ouc...
  • May 28, 2016

For Osteoporosis "This has been the worst experience of my life. Two shots of Prolia and nothing but constant pain. Every bone in my body hurts, literally. I feel just awful all day long. Tired, washed out, constant pain that has been, at times, debilitating. Had to use crutches for two days when I developed severe hip pain and again when I developed severe knee pain. I am eating ibuprofen like it was a bag of M&M's. My cholesterol went high and I have never had a problem with cholesterol in my life (found out that it was yet another side effect). I have been to the ER twice and the walk-in clinic three times since starting Prolia. Two shots and I am done with it, no more."

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  • MDa...
  • February 6, 2020

For Osteoporosis "I have had two Prolia shots and the third one will be due in March. Right from the outset, I experienced bone pain through my hips and down both thighs. Fit, healthy, and active, I have had to force myself up flights of stairs. I notice that in the past couple of weeks, the pain in my legs has taken on a burning sensation and has moved down to my shins. I get out of chairs as if I have arthritis. Absolutely ridiculous! I am going to my GP tomorrow to let him know I have finished with this drug. I saw an endocrine specialist who reluctantly wrote me up for a bone scan later in the year, 'because we know this drug works, we don't need to do scans.' Well, I will continue to take my good calcium supplement and D3 (5,000u a day) and hopefully can get back to running and walking the long distances I did easily prior to these injections. I have two friends on the injections with no problems. A third has just had her first one, and nothing adverse yet!"

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  • Aus...
  • May 27, 2015

For Osteoporosis "I, too, had the constant itching and felt like something was crawling on me. I used Gold Bond Extreme Moisture Lotion, which helped somewhat. I gained 15 pounds in a matter of 2 weeks, experienced shortness of breath on exertion, and felt confusion. This was only my first injection, and I am due for a second in 2 months, but I'm not sure if I want to go this route again. This is a monoclonal antibody, not a drug, and it affects the body differently. There is no antidote for this if you have a reaction, so you are stuck with the problems for quite some time."

4 / 10
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  • ang...
  • August 25, 2015

For Osteoporosis "HORRIBLE side effects! Loose tooth, needed extraction. Dentist found a healthy root, no problem with tooth. Lumps formed in several places. Rashes, shortness of breath. Hoarseness, headaches, joint pain...many more complaints."

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  • Dan...
  • Taken for 1 to 2 years
  • August 10, 2019

For Osteoporosis "I just had my second Prolia shot and it has been a nightmare. My doctor did not tell me about the perils of stopping this drug. I feel like a street drug addict. I have had severe bone pain. I cannot keep my calcium level at a correct level. When I report other numerous side effects to my doctor, he says it was not the Prolia. Now I find out that doctors are getting paid to prescribe Prolia. This is a medical nightmare that will not end. DO NOT TAKE THIS NO MATTER WHAT A GREEDY DOCTOR TELLS YOU."

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  • DMD...
  • February 20, 2016

For Osteoporosis "About 3 days after my Prolia shot, I had severe pain in my lower back, right side. Very different from regular lower back pain due to aging. My doctor prescribed physical therapy (not believing it was due to the Prolia injection) which provided temporary relief. But guess what!!! At the 6-month point, when the Prolia was out of my system, THE PAIN WENT AWAY. Duh. In the past, I took Fosamax (for 6 years) with no side effects. But...I am done with patent medicines. Am reading the book Your Bones, and plan on following their 'natural' approach. I did report my experience to the FDA; my doctor (who I really like) didn't react very seriously to my concerns, only listed it as an allergy on my chart. Don't docs ever talk to the FDA???????"

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  • Ali...
  • Taken for 5 to 10 years
  • October 27, 2019

For Osteoporosis "OMG, having read some of these comments, I'm more convinced than ever that my symptoms are Prolia related!! I have lost count of how many doctors/specialists I have seen. Rheumatologists, Endocrinologists, Neurologists. I have been tested for every imaginable thing, all come back clear!!! 'You're a mystery woman,' they say!!! I have questioned Prolia, 'doesn't do that,' they say... 'keep having it for your bone's sake,' they say!!! Well, I'm done with it. I'm miserable, can hardly walk. Everything hurts, bed is a nightmare. Can't do anything without groaning, life sucks!! I can't believe that no one listens to us, the users... aren't we the real voice of how this drug is affecting us?"

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  • Can...
  • December 25, 2019

For Osteoporosis "I have years (30+) dealing with Fibromyalgia, Osteoarthritis in every joint, chronic pain, anxiety and doctors that seem to feel my suffering is better than having any quality of life because the side effects of those remedies may mean physical dependence. So at 53 years old, a diagnosis of osteoporosis so MD says let's go with Prolia. I figure the doctors are finally taking my health as seriously as I do. I have never felt more exhausted, heavy chest crushing chest pain, high blood pressure, tachycardia and exercise intolerance where I cannot even climb a flight of stairs. Multiple emergency room visits and sent home like a hypochondriac. Started pretty much with the first Prolia injection and there will not be a second. I only hope I do not have a major coronary event before this thing wears off. I have a high-stress nurse manager job that I have always been able to manage. This treatment sucks and I would rather break every bone in my body due to the OP than go through this a moment longer than I have to."

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  • PAM...
  • Taken for 2 to 5 years
  • August 16, 2019

For Osteoporosis "My first shot of Prolia in 2017 was ok, then after the second shot the side effects broke loose. Now 2 and a half years later (I stopped taking it of course) I still have a screwed up bowel system, bad IBS (irritable bowel syndrome), lots of small fractures, my life is ruined by this awful medicine. Don't take Prolia no matter what!"

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  • dep...
  • May 17, 2015

For Osteoporosis "I just got my 3rd shot. I feel miserable. Back, arm, legs pain, headaches, weight gain, along with other side effects. I WILL STOP this Prolia treatment."

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  • Anonymous
  • October 16, 2016

For Osteoporosis "One shot in March 2016 and have experienced the worst seven months of my life, began with a headache so bad, I had an MRI three weeks after the shot and another two weeks before the headache stopped. Then the infections started - ear, bladder, kidneys, and chest. It has been a living hell, cost a fortune, and I can't even translate the pain and suffering. It would take a book that no one wants to read. And it's not done with me, after seven months, I have a chest infection now that I can't get rid of. Worst experience of my life!"

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  • Smu...
  • January 5, 2020

For Osteoporosis "I took my 1st & last Prolia shot in Nov. 2019. Immediately, my mouth and tongue went numb and has continued to happen off and on. Severe headaches, the worst jaw and ear pain ever. I’ve also had 2 different cases of MRSA in my right ear. My leg muscles feel locked up at times, making it hard to walk, and sometimes causes me to lose balance. I have constant bone and muscle pain in my neck, shoulders, back, ribs, and abdomen. I itch so bad at times I scratch constantly. Severe constipation. Bouts of vomiting that come out of nowhere. Fever and chills. I’m sure I’m leaving other side effects out. I was already living with chronic pain daily basis, this shot has caused my pain level to skyrocket and become constant. I hope the side effects will subside soon and go away completely at some point. My GP asked me to at least try one shot. In 2018, I fractured my back at the L-2, Oct. ‘19, another fracture at the T-8. I would strongly advise you to not take it, based on my experience."

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  • Lay...
  • July 28, 2016

For Osteoporosis "After two shots, I had swelling in both elbows, a stiff neck, and pain. I am not sure if Prolia is the cause, but I will not risk it again or any drugs for osteoporosis. My immune system was compromised, and I have had several illnesses. I went from an active, fit person to not being able to perform simple everyday tasks without significant pain. I have had the worst 6 months of my life. Avoid this medication!"

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  • Kay...
  • September 12, 2019

For Osteoporosis "My main experience with this drug is having doctors and nurse practitioners practically force me to take it, through fear tactics and intense pressure. I tried the once-a-year Reclast infusion, but got bad vertigo and nausea, so they switched me to Prolia. I read reviews and was so scared that I decided to never take it again and skipped about a year. My rheumatologist met with me and convinced me to take it again because my bones were so bad. After the second shot, I developed a UTI, but the ensuing bone density scan was encouraging. My third shot was on April 3, 2019, and on April 4, 2019, I woke up with severe vertigo, and landed in the ER. The doctor said it was just a coincidence. I told the doctor I'm not taking it again. We have an appointment next week, as he says we need to discuss a plan, as getting off this can cause fractures in the spine. This sounds like a no-win situation... not sure what to do now, and I have no one I can trust for good advice!"

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  • CMo...
  • July 10, 2016

For Osteoporosis "Can anyone tell me how long it stays in your system, please? Had only one injection, won't have another but want to know if these awful side effects will subside in time now that I've decided to stop them. Thank you."

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  • Jil...
  • September 17, 2016

For Osteoporosis "Please do your homework before taking this awful drug. My Dr. never told me about any potential side effects, and I got them ALL. So sick for months with severe lower back pain radiating around the front. Severe upper GI issues with nausea and haven't been able to eat for months. Lost 15 lbs so fast that my skin is all wrinkles and loose. I look 20 years older than before taking this drug. Spent so much time at Dr's trying to figure out what was wrong with me, and all tests came back negative. Only possible thing is Prolia shot. Headaches, chronic fatigue, poor sleep. Ended up in ER thinking I was having a heart attack...pain was debilitating. At least I found out my heart is good. Have had 3 additional episodes like this. BEWARE"

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