Rexulti User Reviews & Ratings (Page 5)
Rexulti has an average rating of 6.6 out of 10 from a total of 490 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 26% reported a negative experience.
Reviews for Rexulti
- Sco...
- Taken for 1 to 6 months
- November 28, 2018
For Major Depressive Disorder "This is by far the most effective antidepressant I have ever taken, after 23 years of drug therapy and numerous combinations. The only side effect has been some mania, causing me to feel like my 'brain is on fire'! So I do suffer from insomnia, mostly because of the increased brain activity. But I had insomnia before taking Rexulti, so this is not a new symptom. The 'mania' is not a negative; I am extremely productive and never get sad, stuck, or depressed."
- Jan...
- Taken for 1 to 6 months
- September 17, 2019
For Major Depressive Disorder "I've been anxiety-ridden since 7 years old with depression. Would not take psych meds until I finally had a severe breakdown with agoraphobia. Zoloft helped, but 5 years ago at 56, I needed inpatient care and outpatient programs. I tried over 15 additional meds, nothing worked. Abilify a bit, but too hyper. Rexulti has been great. Gets rid of anxiety fast and depression too. It does stimulate my appetite, and I've gained 20 lbs."
Frequently asked questions
- What is Rexulti used for and how well does it work?
- Why does Rexulti cause weight gain?
- How long does it take for Rexulti to work?
- How does Rexulti work?
- uhh...
- Taken for less than 1 month
- February 15, 2020
For Major Depressive Disorder "I hate this medication (I had an adverse reaction). A couple of years back, my psychiatrist gave me a free trial of Rexulti to replace my antidepressant (I don’t remember what mg). I took it for about a week and a half before I started to have strong, consistent suicidal ideations. A week later, I put myself into a psychiatric hospital with the support of my therapist and psychiatrist. The hospital didn’t have any Rexulti, so I was forced to come off of it. After a week or so without taking it, the suicidal thoughts started to fade, and I was back to the depressed-but-not-suicidal state I had been in beforehand. I would give Rexulti 0/10 if I could."
- Cha...
- Taken for less than 1 month
- November 16, 2016
For Major Depressive Disorder "I have MDD severe/recurrent, gen anx w/a big social element, ADD & intrusive thoughts. I was about ready to go to an inpatient facility until my doc prescribed Rexulti. While still on the starter pack, I noticed significant improvement. I also take Effexor & Klonopin. (Ritalin for the ADD) I have mixed feelings about the side effects. I was super morbidly obese and lost 1/2 of my body weight. The weight gain, up at 3-3:30 am and severe am dizziness are starting to wear me out. My doc says no more than 6 months but I have gained 7 lbs in 3 weeks so I am not sure I want to see how much I will gain over the next 5 1/2 months... but, I was 1st diagnosed at 16, now 44 & I will say this drug is a lifesaver. The discount card program makes it 0.00!"
Are you taking this medicine?
Your review helps others make informed decisions.- Hap...
- Taken for 1 to 6 months
- July 19, 2024
For Depression "0.5mg I felt like my life was given back to me. I felt the urge to stop drinking and going back to the gym. I was making plans for the future, even thinking straight. I felt 30 years younger again. Loved shopping again... can't say enough. Did get some cherry stools but I had eaten cherries. I actually lost weight."
- Anonymous
- Taken for 1 to 2 years
- October 15, 2016
For Major Depressive Disorder "Probably the best antipsychotic I have ever been. I have only responded to Abilify, and yet I still had some intense residual depressive, obsessive-compulsive, insomnia, and anxiety symptoms not allowing me to function well half the time-the side effects of Abilify were also too much. My doctor told me about Rexulti and how it is a better and cleaner version of Abilify, therefore, I agreed to try it. I have now been on it for a year, and it has helped me in ways that I am glad that I switched to it. The only issue is that it still causes weight gain and diabetes, but these are less severe than on Abilify. It is worth dealing with those side effects because now I no longer have insomnia and can function thanks to Rexulti."
- Jun...
- Taken for 2 to 5 years
- March 19, 2019
For Schizophrenia "Go ahead and take this medicine if you want to mentally feel better, but be prepared to gain 30 pounds and never be able to lose it. Honestly, I don't recommend it at all because the weight gain has ruined my life. Good luck in whatever you decide to do."
- Kel...
- Taken for 2 to 5 years
- May 1, 2020
For Depression "Ok, so I've been on Rexulti for a few years now for depression. This is the best advice I can give someone thinking about taking this medication. Currently, I am on 2 mg, I take it for major depression. My doctor started me off on 1 mg. It seems like I had side effects from the drug in the beginning: dry mouth, weight gain, irritability, and fatigue. So I started taking it at night. After about 2 weeks, I then switched to morning again. Side effects went away except for me eating :(. Overall, it's a good drug if it helps. I would recommend it. DOWNSIDE: do not just stop taking the drug! You must taper down on the medication. You will have effects if you just stop taking it. For example, moody as heck. Then it takes a few days to build the medicine back up in your body for it to go away."
- Jyl...
- Taken for less than 1 month
- December 11, 2018
For Schizophrenia "Since starting Rexulti a week and a half ago, I've been feeling more motivated, I have more energy, and I feel less irritable. I'm studying more productively. I haven't been experiencing intrusive thoughts - obviously, I can remember what they were, therefore they still enter my mind, but they're not distressing, and they don't linger. So, ultimately, I feel 'normal' again, i.e., without illness or side effects. (I'm still overweight, and I still procrastinate, but since beginning this new treatment, I have the motivation and energy to transform to the person I want to be.)"
- Sop...
- Taken for 1 to 6 months
- February 3, 2020
For Major Depressive Disorder "Rexulti took time to start working, and now I feel better than I have for a while. I've lost my parents and my ESA in the last 6 years. The downside is the weight gain. I've gained 20 lbs in a short period of time. I can't afford to gain weight, I'm already big. I eat the same things, I don't snack. In comparison, before Rexulti, I ate more than I do now and didn't gain weight. It's the weight gain that makes it problematic."
- AJ6...
- Taken for 1 to 6 months
- February 8, 2019
For Major Depressive Disorder "I’ve been taking Rexulti for about 6 months now. I’m presently taking 1 mg/day. This medication has changed my life. I was on an SSRI (Zoloft then Paxil) for almost 18 years. I had severe breakthrough depression with menopause about 5 years ago, and the SSRIs were no longer working. In the past 5 years, I have been on numerous medications including atypical antipsychotics, mood stabilizers (Lithium, lamotrigine), Lexapro, and Latuda. Nothing was helping, and I was so low I was having persistent suicidal thoughts at one point. My psychiatrist started me on Rexulti on a whim. I feel like a new person. More energy and zest for life. I also take Seroquel for sleep, which I’m hoping to wean, and Adderall 20 mg in the morning. This combo works well for me. It is an expensive drug, but you can print an online coupon from the Rexulti website for a maximum $15 monthly copay with insurance."
- Zip...
- Taken for 1 to 6 months
- October 14, 2016
For Major Depressive Disorder "I'm taking this for bipolar 2 with major depressive disorder that has been treatment-resistant for over 5 years. Rexulti is the first drug that has ever worked for me. I have tried virtually everything previously, with things making me a zombie, worse than I was, or simply nothing at all. Rexulti has been a miracle drug for me. It does give me insomnia, so I'm going to try to switch to taking it in the morning to see if that helps. I am on a 2 mg dose."
- Cor...
- Taken for 1 to 6 months
- August 25, 2018
For Schizophrenia "Rexulti is the first antipsychotic I've been on with no apparent side effects. It has my schizophrenia under control and has completely gotten rid of my voices. It also helps control my paranoia, psychosis, and helps with my gut-wrenching anxiety so I can get out of my apartment and lead a normal life. I have nothing but good things to say about Rexulti."
- Not...
- Taken for 1 to 2 years
- March 3, 2019
For Major Depressive Disorder "Rexulti is amazing in two categories: 1) depression and 2) massive weight gain. The weight gain does NOT come off when you stop Rexulti. Four years later, I’m still struggling with the 40 lbs I gained."
- ram...
- March 16, 2017
For Major Depressive Disorder "I have been on Rexulti for about a year. A lifesaver!! I'm no longer stricken by depression and doomed with sadness and unmotivated. Rexulti has given me my life back, and I actually want to leave the house and do things. Great medication, not for everyone, though. I also did gain 30 pounds. Only downside."
- Anonymous
- Taken for less than 1 month
- October 7, 2015
For Major Depressive Disorder "I've just started the starter pack of Rexulti. I am on day 3. It is replacing Abilify in my meds. I feel a lift in the depression, however, I am experiencing some agitation and anxiety. I'm hoping this improves. It is affecting my dreaming, they aren't nightmares, just very vivid and strange. I am hopeful for this medicine if we can just get the agitation to cease."
- Rob...
- Taken for 2 to 5 years
- November 3, 2024
For Depression "I started taking Rexulti about 2 years ago. I was in the middle of a total mental breakdown. I've struggled with anxiety since I was 12 and been medicated since 13. But for some reason, in 2020, at age 21, I became inconsolable and unstable. I was in the ER twice in one week for panic attacks that got so severe I thought I'd die. I was miserable, my body felt like it was shutting down, but every test was normal. I was ready to give up. All the medicines I tried failed - clonazepam, aripiprazole, everything. Then my psychiatrist found Rexulti. Within a matter of days, I was cured. I felt great. I felt alive. I felt even better than I did before the breakdown. And ever since, I've been doing amazing. I love life again and am safe and happy. I only take 0.5 mg a day, in addition to my venlafaxine 225 mg. My psychiatrist thinks this works as an additive to the venlafaxine and bolsters the effects. Whatever it is, I'm so thankful for what this treatment has done for me. It saved my life."
- Gra...
- Taken for less than 1 month
- February 1, 2024
For Major Depressive Disorder "This med is a miracle. I have major depressive disorder, c-ptsd, fibromyalgia, and chronic fatigue syndrome. I was already taking Zoloft, and it helps-ish, but the Rexulti is great... it gives me energy, makes me sunnier, and almost a little jolly, but most surprisingly, it keeps my nervous system calm and not always on the brink of activating and leaving me to feel awful. If you have PTSD, you know what I mean. The combo of health issues I have is so hard to treat because how do you feel calmer and less activated but also energetic? Amazing that this does that. Also, I feel so much more regulated as far as upset, anger, and triggers but not in a 'medicated' cloudy way like Xanax. The mood just passes like before I had PTSD. I don't feel so sensitive to every little noise and thing when I'm out in the world. I only take 0.25 mg! It's only been two weeks. It is a little harder to sleep and the dreams are vivid though. Hoping I don't get akathisia. This will put a pep in your step."
- Sar...
- Taken for 1 to 6 months
- September 7, 2018
For Major Depressive Disorder "I never thought I would feel alive again. I have struggled with major depressive disorder for six years. I’ve been on many medications hoping each time it would be the “magic pill.” When I started Rexulti, it took about two weeks for me to feel the positive impact of the medication. I feel present and a part of life again. I can get out of bed and do things and be happy! I am grateful for Rexulti and how it has helped me."
- Ink...
- Taken for 1 to 6 months
- January 3, 2019
For Major Depressive Disorder "I believe this drug has been the best to treat my depression, bipolar, and PTSD. I went from having suicidal ideations on a daily basis, and now I only have intrusive thoughts on occasion. I would recommend trying this drug if you get a chance. I tried Seroquel, Abilify, and all they did was make me tired and gain weight. Rexulti has been a great addition to my Lamictal to help balance my bipolar depression. I give Rexulti a 9/10."
- Sha...
- January 5, 2017
For Major Depressive Disorder "First couple of weeks were good, but after that, had a lot of nervous energy and a lot of waking up throughout the night. About a month in, I began having intrusive thoughts and had to be hospitalized. They took me off the Rexulti, and the intrusive thoughts went away after about two days."
- Ear...
- Taken for 6 months to 1 year
- July 28, 2019
For Major Depressive Disorder "I have bipolar disorder, MDD, and GAD. I tried Abilify as an add-on, and it made me so tired all the time, and I gained weight. We switched to Rexulti, and I immediately felt fabulous. I was stable and optimistic! Soon after, I noticed I was eating nonstop. It was like an addiction. I struggle with weight as it is. I take Vyvanse for ADHD, and it helps curb my appetite a little, but the Rexulti still makes me want to eat all the time. Also, I've noticed it makes me really restless and irritable. I think it actually induces hypomania in me. I end up having major outbursts of anger and rage. It's even taken a toll on my marriage. I had to stop. I feel a little depressed, but it's better than being out of control."
- Mel...
- February 19, 2020
For Depression "I have been on Rexulti for approximately a month now, starting at the 0.5 mg dose and now I am titrating up to 1 mg. I’m on an 8-day cycle of alternating between the 0.5 mg and 1 mg, respectively. This medication was prescribed to me as an add-on to Persistent Depressive Disorder (dysthymia) by my psychiatrist. I am also prescribed Wellbutrin XL 300 mg and Cipralex 20 mg. This cocktail seems to help me enough to get up for work and continue my duties in home life as a husband and father without considering killing myself. Before I was given Rexulti, I was semi-suicidal daily, so I guess it is helping. It is supposed to stabilize mood and give me an extra boost to get going, however, I do feel somewhat sedated while on this drug, especially on the days I take 1 mg, which to me is not a bad thing. I would rather feel okay and sedated vs. sad but energetic."
- Cat...
- Taken for 2 to 5 years
- August 28, 2019
For Major Depressive Disorder "Rexulti helped save my life! I have been on it since 2014. Thanks to this drug, I have only had 2 episodes of MDD. I have suffered from depression since I was in my late teens, and I am 57 years old now. I had my first experience with MDD in October of 2013 and my second one sometime in 2016. My second episode of MDD was a lot milder, and I was able to recognize that I was battling another bout of it. I owe that all to Rexulti! Rexulti helps the other antidepressants that I am on to work better. I also have an awesome psychiatrist and psychologist that have really, really been there for me over the years."
Are you taking this medicine?
Your review helps others make informed decisions.More about Rexulti (brexpiprazole)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Generic availability
- Support group
- FDA approval history
- Drug class: atypical antipsychotics
- Breastfeeding
- En español
For Depression "I have been on citalopram (Celexa) 40 mg for years, and it just wasn't working anymore. My psychiatrist added the Rexulti 0.5 mg three weeks ago, and I have never felt better! I take them both at bedtime. The only real side effect is nausea sometimes in the middle of the night. I am so grateful to be able to live again. My doctor has given me a month’s more samples while they work to try and get my insurance to accept this new medication. I hope they do because my pharmacy quoted me $1,000 (not a typo) for my prescription!"