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Z-Pak and Upset Stomach: What Users Say

Upset stomach: mentioned by 8 users (23.5%)

Based on user experiences from 34 Z-Pak reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

diarrhea 32.4%
upset stomach 23.5%
anxiety 8.8%
cough 8.8%
dizziness 8.8%
headaches 8.8%
nausea 8.8%
stomach pain 8.8%

Reviews for Z-Pak

Commonly mentioned side effects
  • ake...
  • Taken for less than 1 month
  • May 30, 2020

For Bacterial Infection "These bad reviews terrified me. I took this for strep throat, and within the second day, I was feeling better. I have one more day left and will be done with it. I’ve had no bad issues. The first day with the two pills made my stomach hurt a little and I got mild diarrhea, but after that, I had no more issues. Make sure to eat a full meal when taking it. And stop overthinking! Anxiety causes stomach pain and bathroom issues as well. If you’re freaking out due to the reviews, I would not be shocked if you end up in the bathroom. Please don’t let the reviews deter you. Everyone’s body is different."

10 / 10
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51 Report
  • Flu...
  • Taken for less than 1 month
  • November 6, 2019

For Bacterial Infection "Z-Pak is the only antibiotic I don’t have an allergic reaction to or side effects from. I agree with the reviews, it either works fast and is awesome, or it doesn’t work. If you need a second dose, your illness is probably something else. Pop a Pepcid before taking it and eat while you take it, it prevents heartburn/upset stomach. Be well out there and please stay home if you’re sick :)"

10 / 10
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17 Report
  • wil...
  • Taken for 1 to 2 years
  • October 15, 2014

For Bacterial Infection "I am allergic to just about every antibiotic out there, but the Z-Pak is pretty good in taking care of the sinus infections I get without too many side effects. A little bit of upset stomach occurs, but it's minor. Z-Pak always takes care of the infection promptly."

9 / 10
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17 Report

Frequently asked questions

  • Bes...
  • Taken for less than 1 month
  • March 8, 2023

For Bacterial Infection "I’m allergic to many antibiotics, and the ones I’m not allergic to make me physically ill with nausea and terrible stomach upset. This is the only antibiotic I can take without worrying about horrible side effects. I highly recommend it. It’s also easier to take than many other antibiotics that you have to take multiple times a day. Don’t let any bad reviews scare you, this is a great antibiotic! I’m currently on it for a root canal. But I’ve had it a couple of times in the past for other issues."

10 / 10
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3 Report
  • Nev...
  • July 20, 2017

For Bacterial Infection "Took first dose of two tablets for bronchitis and lost all ability to taste food in a few hours, also had to leave work as I felt very tired. No change to bronchitis symptoms. Day two, continues to have no ability to taste food and headache (5/10) began after the second dose. Bronchitis symptoms mildly improving. Following the third dose, severe headache and earache, took tramadol, which made it manageable. Not taking the fourth dose, currently experiencing horrific stomach cramps and diarrhea. Still can't taste anything and have a significant headache. Felt much better with bronchitis symptoms, feel like death. Never again."

2 / 10
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7 Report

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  • Ima...
  • Taken for less than 1 month
  • March 19, 2023

For Tonsillitis/Pharyngitis "Literally a lifesaver!! Was in agony and had a terrible sore throat, strep, and tonsillitis - within 12 hours of taking the medication, I had some stomach cramps but no sore throat and was feeling so much better. Z-Pak is a miracle antibiotic."

10 / 10
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1 Report
  • l3x...
  • Taken for less than 1 month
  • January 30, 2025

For Bacterial Infection "Prescribed a 125 mg pack for a severe sinus infection (and possible pneumonia) and felt 95% better by the end of the second day. Had a tiny bit of stomach cramps and loose stool on the first day, but that’s to be expected with any antibiotic. I swear this stuff is magical."

10 / 10
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0 Report
  • 123...
  • Taken for less than 1 month
  • February 2, 2020

For Bacterial Infection "It doesn’t work, and if anything, it makes me feel worse. It gives me an upset stomach, and I get super dizzy every time I take it."

1 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.