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Saphris User Reviews & Ratings (Page 3)

Saphris has an average rating of 7.4 out of 10 from a total of 318 reviews on Drugs.com. 69% of reviewers reported a positive experience, while 17% reported a negative experience.

Reviews for Saphris

Commonly mentioned side effects
  • Jes...
  • September 13, 2017

For Bipolar Disorder "After 15 years of trying different meds, this is the first one to give me a positive change. I used to be suicidal every day and had a hard time leaving the house. Everything was overwhelming. Since starting Saphris, my mind finally feels like it has 'brakes,' and my thoughts feel lighter. I'm feeling true happiness, even happy to wake up. Little to no side effects, 3 months in. I take it at night because it does make me sleepy. Sugar cravings I've noticed, but I'm trying to control that because honestly this med is giving me my life back. Cons: 20 minutes of a nasty taste in your mouth because you dissolve it under your tongue. Sugar/carb cravings, but no excess weight gain yet."

9 / 10
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  • Mit...
  • September 19, 2017

For Bipolar Disorder "After trying several meds, which helped, I was introduced to Saphris at 10 mg/day. I experienced periods of debilitating drowsiness, so I decreased to 5 mg. The problem disappeared. Mentally and emotionally, I feel almost normal. Mood swings are slight and manageable. I like Saphris."

10 / 10
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  • Ano...
  • December 20, 2013

For Bipolar Disorder "I have Bipolar Disorder I, with rapid cycling and mixed states. I tried Saphris when I was recovering from a hospitalization, which was very unpleasant and ended very badly. So I was a bit manic and terribly anxious going on it. I took it for 6 days. It seemed to work almost right away. I was shaky and anxious throughout the 6 days. Extremely sleepy and dizzy after my 5 mg at bedtime. But that wore off after 4 days. Mood-wise, it seemed to completely stall my cycling. Miracle! And I was much calmer and less reactive, but definitely awake during the days. Then, after my 6th dose, I noticed my lips were puffy, and my tongue was fatter, then my throat got tight = allergic reaction. Worked great until that!"

9 / 10
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  • Emi...
  • April 23, 2017

For Bipolar Disorder "Worst medication I've ever been on. It has made me very flat, depressed, quiet, overweight, and also a case of anhedonia. I can't even talk to people anymore, just short answers and no enthusiasm. I also don't even enjoy nature anymore, and I used to LOVE the outdoors. I've been feeling like a robot ever since I went on it 6 months ago. I know I should have told my doctor sooner. Last week, I started dosing down and am praying that once I'm completely off of it, I'll be feeling better and hope to have more life in me. I'm glad to see that it works for most people. Has anyone else experienced any of these side effects?"

1 / 10
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  • Any...
  • Taken for 1 to 6 months
  • November 8, 2015

For Bipolar Disorder "I have been on various antidepressants since I was 18, with some relief at times. I've been very functional all along but never happy. I've used other illicit substances to self-medicate. I saw a psychiatrist when I finally got sick and tired of spinning my wheels. She diagnosed me with bipolar 2 and put me on Saphris. For the first month, I felt AMAZING. I was getting things done at home, at work, and even nurturing a social life again. The med still works weekly for my mood, but I've gained 20 lbs in just 2 months. This is really starting to get me down. The med had changed my life, but I'm not sure how much longer I can deal with the weight gain. If it weren't for the weight, I would've given it a 10."

8 / 10
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  • Mrs...
  • Taken for 1 to 6 months
  • March 26, 2016

For Bipolar Disorder "Started on Saphris 2 months ago for sleep and bipolar. I started at 5 mg---total nightmare! Couldn't sleep, picked arguments with my husband, and was generally very hyped and energetic (in a good but bad way!). I never saw a manic episode coming at me--but I saw this one! After 5 days, I called the doctor and was advised to go up to 10 mg. WOW!! Immediate turnaround that night (I only take it at night), and my sleep was fantastic! My attitude was amazing, and my husband was delighted with his loving and easygoing wife! I felt great--not drugged, just happy and content. Work with it--it's turned my life around!"

10 / 10
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  • Kri...
  • Taken for 6 months to 1 year
  • August 17, 2013

For Bipolar Disorder "I am currently taking 1/4 of a 5 mg tablet (but started out on a 1/2 tablet) of Saphris at night. I am also on Lexapro, 10 mg for depression and anxiety. The combo works great. I have horrible insomnia/waking in the night on just Lexapro (or other SSRIs I've tried), but with Saphris I sleep great and wake up refreshed! Only downside is that I've put on 10-15 pounds in the last 6 months, but not sure if it is due to Lexapro or Saphris or both. I eat very healthy (just too much) and exercise regularly... but find myself always feeling hungry. Oh well... at least I'm happy!"

9 / 10
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  • Ton...
  • March 31, 2012

For Bipolar Disorder "I am bipolar, and I was not on a mood stabilizer due to severe sensitivity to side effects. I take Klonopin 1 mg and Lamictal 150 mg twice a day. I was taking Ambien for sleep, but now with the Saphris, I don't need any sleep medicines, and I am so much more relaxed and not stressed out. I'm very happy that I've finally found something that is working. My mind has slowed down, deeper sleep modes, and less stress reactions to people. I feel great. Not manic great, just great. I'm thankful to my family for their support and standing by me in the rough times of the disease. My family is benefiting as well. I have to rate this as a 10. The taste is bad, but the cherry is helping. Much luck to all to try and see if it can help you too!"

10 / 10
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  • Lif...
  • Taken for 6 months to 1 year
  • April 9, 2014

For Bipolar Disorder "I started out with 20 mg of Saphris but stayed groggy. Went down to 10 mg and have been on it for 6 months. I also take a sleep aid at night and now I sleep 6-7 hrs compared to 3-4. No running thoughts in my head. The longest time I have ever stayed out of the hospital in 12 years. I feel wonderful, when I start getting anxious, I take a 5 mg with my Xanax, and I am good to go. Downside: Gained 50 lbs, and cholesterol is through the roof, even though I do not eat red meat. Always have the munchies, though. Had to start on a statin medicine. Blood sugar is higher than usual but within range. Keeping an eye on this too. But this is the only medicine that has worked for me without being a zombie or continued mixed episodes."

9 / 10
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  • Gra...
  • Taken for 1 to 6 months
  • March 10, 2013

For Post Traumatic Stress Disorder "I have been on Saphris for about 5 weeks. I started at a low dose, 5 mg at bedtime and just increased to 10 mg a couple days ago. I love this medicine! I sleep at night and wake up feeling good in the morning, I haven't experienced that in YEARS! My PTSD episodes have greatly decreased in intensity, duration, and how often they occur. I really do feel like a new woman!"

10 / 10
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  • Box...
  • Taken for less than 1 month
  • October 25, 2012

For Bipolar Disorder "I have been taking Saphris for 10 days. I went cold turkey off Seroquel 600 mg/day. I have had terrible insomnia. My psych said this should improve over the next few weeks, I hope so. I agreed that it tastes awful, and numbness under my tongue only lasts approximately half an hour. My mood improved the next day after my first 5 mg dose. I feel so happy and enthusiastic about life, which is amazing. The Seroquel fog has lifted, and I have lost 3.5 kg in 7 days (Seroquel munchies are gone)."

9 / 10
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  • Lov...
  • Taken for 1 to 6 months
  • September 14, 2016

For Bipolar Disorder "I had tried many medications to level out my bipolar disorder and relieve my GAD, and it seemed that when I would get one symptom straight, one of the others would reappear. Years it took, eventually, my doc decided to try something new when the depression hit and nothing seemed to be helping. So, I started Trileptal, which helped noticeably, but I wasn't sleeping, so he recommended Saphris to help me sleep. I was a little apprehensive but desired to feel better, so I agreed to try it. I am beyond satisfied with it. I feel better than I have been in as long as I remember. I am back in school full-time and working full-time without the edginess of mania. I feel like myself again. My friends and family have commented on how well I seem to be."

8 / 10
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  • Anonymous
  • March 19, 2012

For Bipolar Disorder "I have struggled with bipolar disorder for twenty-some years and have never been stable. I've tried most of the atypicals and all the mood stabilizers. After Saphris, I am stable for the first time in my life. The shadows, delusions, mania, depression, anxiety, and sleep problems are all gone. I take the black cherry as I cannot tolerate the original, but the taste is worth it in how well it works. Two weeks after starting it, it was like someone turned the lights on. The world was literally brighter! I am back in school, working part-time, and happy, and I didn't think it possible. I've been through 38 ECT treatments and every medicine without success before 20 mg Saphris. It's a miracle for me. I now take two medicines, down from 9!"

10 / 10
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  • joh...
  • February 22, 2010

For Bipolar Disorder "Dissolves very quickly compared to other sublingual tablets that I have taken - tastes horrible though! I have experienced no negative side effects, and it has definitely elevated my mood and taken away the 'shadows' and some of the 'noises' that accompany my diagnosis....overall seems to be much better than the last two meds I was prescribed (Lamictal and Abilify). I give it a ten!"

10 / 10
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  • Ken...
  • Taken for less than 1 month
  • December 18, 2015

For Bipolar Disorder "I have been on Saphris now for 1 month. I have not been this happy in 35 years! I am working out every day now at the local health club. Last night, I swam for over 40 minutes straight. The only side effect of this med is excellent REM sleep and a good night's rest. Heaven help you if you don't have insurance... Very pricey $$$$$."

10 / 10
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  • Hei...
  • February 18, 2016

For Bipolar Disorder "I took Saphris and was given 10 mg samples from my Dr. I felt great! After a few weeks of samples, I went to fill my prescription. After insurance, it was $400.00! I couldn't afford to get it filled. It really stinks that a medication that made such a difference for mental health could be so costly. I can only imagine this is why so many go without medication for mental illness."

9 / 10
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  • Anonymous
  • October 23, 2011

For Schizophrenia "For the first few weeks, I felt amazing. So much better, I couldn't believe it. I hadn't been that totally free from visions with any other medication. I didn't much enjoy randomly falling asleep when I took my afternoon dose, but at the time, it seemed worth it. However, after about a month, I started feeling like the best thing for me to do would be to kill myself. I didn't get depressed, none of my old symptoms returned, I just felt like it was the logical thing to do. It felt so normal that I didn't report it to my doctor for a month. He told me to stop taking Saphris, and within 2 weeks, all of my suicidal thoughts stopped. My symptoms returned, but it was a fair trade. I just want people to know and to be careful."

3 / 10
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  • ken...
  • Taken for 1 to 6 months
  • February 25, 2018

For Bipolar Disorder "I don't know what the big deal is about the taste-I have the cherry, and yeah, it's not great, but if you want to feel better, then you have to deal with it-feeling better is all worth it to me... has helped me greatly-do not be afraid to try it-"

10 / 10
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  • HiS...
  • Taken for less than 1 month
  • February 7, 2015

For Bipolar Disorder "Diagnosed ADHD, bipolar, major depression, GAD, panic disorder. Have been on Saphris 5 mg at night for 1 week. After the first dose, I could tell a huge difference in my mood. For the first time in months, I woke up in a great mood. After a few days, I knew I was no longer in mania, which I've been in for at least 4 months. My thinking is back to normal. The only problem I'm having is keeping my mood stabilized. When I take it at night, it puts me to sleep in 15 minutes. No longer using sleeping meds. For one week of use, I think it's a great medicine."

9 / 10
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  • dje...
  • Taken for 6 months to 1 year
  • June 29, 2014

For Bipolar Disorder "Bipolar with mixed episodes, ADHD, and severe anxiety. Saphris was a miracle for me also. I've been on disability for 10 years, and this is the first medicine I've taken that has made me functional. Absolutely can't take it in the morning; it makes me incoherent for about 3 hours, and I eat everything in sight. So I take all 20 mg at night and am doing fine. Have mouth sores, though. My doctor said to alternate between taking it sublingually, supralingually, and buccally, and it's helping."

9 / 10
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  • Tat...
  • Taken for 5 to 10 years
  • March 3, 2020

For Bipolar Disorder "I've been on Saphris for about 6 years or more. In my personal experience, I believe I have been exceptionally well. When I miss a few days, I realize how off I become, but I go back to normal while I'm on this medication. I think doctors should familiarize themselves with this medication more because I think it would be great for others that suffer with bipolar disorder."

10 / 10
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  • ELa...
  • July 30, 2017

For Schizophrenia "Saphris has done wonders for me. I have been on 10 mg at night since July 7th, and I have lost 4 lbs already. I was on Invega paliperidone 9 mg for 10 years. No matter how hard I tried (fasting, counting my calories), I couldn't lose weight. I like how Saphris puts me to sleep right away, but I'm not tired the next day. Also, I have my sex drive back, which I never had on Invega. I am so glad they have come up with better medications these days."

10 / 10
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  • Anonymous
  • January 31, 2011

For Bipolar Disorder "I've been on Saphris for a week now. 5 mg/night. Here are my initial thoughts: I feel like it’s summer. It’s a good calmness. The mouth numbing was really bad at first when I took it, slowly getting less each day (it’s always gone by morning). I felt the first couple of days like I had taken a Sudafed; very awake the next morning. That effect is also wearing off day by day. I have been taking it at bed, so I’m not sure if it makes me dizzy still. I can think clearer. I’m sleeping like a log. I feel less cold. My sinuses feel wetter. I actually get hungry now. I feel super non-stressed out. I’m stretching better in my dance, and my joints no longer crack. I feel normal again."

9 / 10
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  • You...
  • July 20, 2017

For Schizophrenia "I've been taking Saphris 10 mg twice a day for over a year. It has helped me tremendously. I no longer hear 9 voices, down to 2 voices that are quiet. I do not get dizzy or tired on it as well. It has given me clarity and rest from voices. It has been good for me so far, so grateful. I no longer have anxiety as well."

9 / 10
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  • clb...
  • December 4, 2010

For Bipolar Disorder "Felt better after the first day, working on day 5. Can't believe how super, great, wonderful, alert, and alive I feel. After 27 years of fighting bipolar disorder, I am amazed. Hope it lasts. No side effects so far, hasn't helped my grammar or spelling. Oh, taste? What taste?"

9 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.