Apremilast and Nausea: What Users Say (Page 5)

• Mar...
• Taken for less than 1 month
• October 23, 2021

Apremilast for Plaque Psoriasis "Started taking a few weeks ago and finally stopped taking it yesterday. Still get nausea and diarrhea after taking each dose. The last few days, my symptoms seem to worsen. I become severely depressed, couldn't concentrate, and felt lightheaded and short of breath all the time. Yesterday, I had to leave work because I became so shaky and lightheaded I almost passed out. I have no history of any of these issues and strongly feel it was the medication. After researching, the negative effects rate is higher than the success rate. I'm mad I started Otezla in the first place."

• Sum...
• January 16, 2022

Apremilast for Plaque Psoriasis "I started Otezla yesterday morning, trying to treat scalp psoriasis. I have had severe diarrhea since yesterday afternoon, lasting all through the night. I also developed a severe headache and nausea, though I have not vomited yet. Since I’ve only had 1 pill and been this sick from it, it’s not for me. I’m sad I can’t take this medication, as I really had high hopes."

• Bat...
• Taken for 1 to 6 months
• October 1, 2021

Apremilast for Plaque Psoriasis "I've been on Otezla for going on 5 weeks now and have seen a nice improvement in the breakthrough psoriasis I developed after 3 years of being on Cosentyx (which I'm still on). Otezla was prescribed as a bridge medication to help Cosentyx, and I must say it's has certainly helped with both my skin breakouts and the crippling psoriatic arthritis I have experienced for the past 5 years. I have not suffered from any of the reported issues like nausea or diarrhea because I eat a little something before I take Otezla, problem solved. I do get the occasional migraine, but I can’t say with certainty it's the Otezla causing it."

• Sal...
• Taken for 1 to 6 months
• April 19, 2022

Apremilast for Behcet's Disease "Was on Otezla for 2 and 1/2 months. Tried to hang in there. The mouth ulcers got worse, then I noticed a spot on my leg... Not sure if it has anything to do with Behcet's. When the doctor said it was psoriasis. I'm going to a dermatologist tomorrow, it got to be about 2 inches long and an inch wide, and then another one appeared. My lip became very ulcerated, and I had vaginal ulcers, which I have not had for several years. I had diarrhea, nausea, and headaches. My doctor and I finally decided that after that length of time my body could not tolerate it. The doctor decided that I needed to go on a prednisone regimen. It cleared up my mouth, but my lips kept getting worse. I am off the prednisone now for 2 days, and now I'm getting more ulcers in my mouth. I wish I had never heard of this drug."

• Flu...
• Taken for less than 1 month
• March 13, 2017

For Psoriatic Arthritis "I rate Apremilast on a 50/50 basis. I've just finished the 2-week starter pack and have had a wide lot of side effects on and off. But today - BAM! Headache, nausea, uncontrollable bowel... I've only just gone back to work after 2 months of chronic PSA and now have had to blow out today because of this drug. As a total plus, though, my psoriasis has halved in such a short time, so I'm going to persevere with this med. Wish me luck :)"

• Por...
• Taken for less than 1 month
• June 6, 2015

For Plaque Psoriasis "I have been using this medication only a week, I am now on full dosage and have had hardly any side effects, which was my main concern. The specialist said I could expect nausea, diarrhea, and some headaches, and possibly vomiting. He also made me aware that these effects would wear off after a couple of weeks of my body adjusting to the medication. I have actually had a couple of small headaches (took paracetamol), a touch of nausea, only when I was moving up to the next level on tablets, and more regular bowel movements...not a bad thing. I feel fine, the psoriasis is starting to clear already :-)"

• Iva...
• Taken for less than 1 month
• January 14, 2023

Apremilast for Plaque Psoriasis "I have to say that this is not for me. Side effects after the second day: diarrhea, headache, nausea, and today was the worst day after 10 days. I had diarrhea and vomiting at the same time! lol, it was really disgusting, so I'm gonna stop taking this. I did not notice an improvement in my psoriasis. I will continue to use my betamethasone ointments. Good luck!"

• Dan...
• Taken for 1 to 6 months
• May 27, 2025

Apremilast for Psoriatic Arthritis "In the beginning, I was nauseous, but that went away, but it constipates me severely. I have to take stool softeners and MiraLAX. I have another problem, but I don’t know if it’s related to Otezla. No matter how much water I drink and I drink bottled purified water, I am still dehydrated. I drank 64 ounces of water today and 40 ounces of another drink, and my skin is not bouncing back. My fingers are like prunes, but then again it’s an autoimmune disease that I have and it could have something to do with that, but I highly recommend this to anyone who has psoriatic arthritis because it helps with the pain and also it was clearing up the psoriasis. I’ve only been on it for two months."

• Sta...
• July 10, 2015

Apremilast for Plaque Psoriasis "Psoriasis started to clear in just a couple of weeks; however, nausea and uncontrollable bowel issues have been an ongoing negative, but the 35 lb weight loss is the silver lining."

• Str...
• June 15, 2015

Apremilast for Psoriatic Arthritis "I'm only on day 7 of this medication, so too early to tell, but I'm experiencing severe nausea, as expected."

• Aur...
• Taken for 1 to 6 months
• October 23, 2019

Apremilast for Plaque Psoriasis "Was on Otezla for 6 months. No help for the psoriasis, instead, I was constantly nauseous during the whole time."

• Anonymous
• December 23, 2022

Apremilast for Plaque Psoriasis "I was sick (severe nausea) for 1-2 hours after every Otezla dose for 6 months, then I decided to stop taking Otezla. After stopping, I flared worse than before I started the medication."

• Ano...
• Taken for 6 months to 1 year
• June 13, 2025

Apremilast for Plaque Psoriasis "Cleared up skin condition. Felt like I had morning sickness. Went off it, but skin and hair so itchy and flaky. Going back on it. Side effects are better than the constant itch."

• LuJ...
• September 23, 2017

Apremilast for Plaque Psoriasis "Tried this med for 6 days; had to stop. Almost went crazy! Severe depression, cried at the drop of a hat, extremely nauseous, IBS, and so irritable, it nearly cost my relationship!"