Apremilast and Nausea: What Users Say (Page 5)

• Sal...
• Taken for 1 to 6 months
• April 19, 2022

Apremilast for Behcet's Disease "Was on Otezla for 2 and 1/2 months. Tried to hang in there. The mouth ulcers got worse, then I noticed a spot on my leg... Not sure if it has anything to do with Behcet's. When the doctor said it was psoriasis. I'm going to a dermatologist tomorrow, it got to be about 2 inches long and an inch wide, and then another one appeared. My lip became very ulcerated, and I had vaginal ulcers, which I have not had for several years. I had diarrhea, nausea, and headaches. My doctor and I finally decided that after that length of time my body could not tolerate it. The doctor decided that I needed to go on a prednisone regimen. It cleared up my mouth, but my lips kept getting worse. I am off the prednisone now for 2 days, and now I'm getting more ulcers in my mouth. I wish I had never heard of this drug."

• Mar...
• Taken for less than 1 month
• October 23, 2021

Apremilast for Plaque Psoriasis "Started taking a few weeks ago and finally stopped taking it yesterday. Still get nausea and diarrhea after taking each dose. The last few days, my symptoms seem to worsen. I become severely depressed, couldn't concentrate, and felt lightheaded and short of breath all the time. Yesterday, I had to leave work because I became so shaky and lightheaded I almost passed out. I have no history of any of these issues and strongly feel it was the medication. After researching, the negative effects rate is higher than the success rate. I'm mad I started Otezla in the first place."

• Sum...
• January 16, 2022

Apremilast for Plaque Psoriasis "I started Otezla yesterday morning, trying to treat scalp psoriasis. I have had severe diarrhea since yesterday afternoon, lasting all through the night. I also developed a severe headache and nausea, though I have not vomited yet. Since I’ve only had 1 pill and been this sick from it, it’s not for me. I’m sad I can’t take this medication, as I really had high hopes."

• Bat...
• Taken for 1 to 6 months
• October 1, 2021

Apremilast for Plaque Psoriasis "I've been on Otezla for going on 5 weeks now and have seen a nice improvement in the breakthrough psoriasis I developed after 3 years of being on Cosentyx (which I'm still on). Otezla was prescribed as a bridge medication to help Cosentyx, and I must say it's has certainly helped with both my skin breakouts and the crippling psoriatic arthritis I have experienced for the past 5 years. I have not suffered from any of the reported issues like nausea or diarrhea because I eat a little something before I take Otezla, problem solved. I do get the occasional migraine, but I can’t say with certainty it's the Otezla causing it."

• Flu...
• Taken for less than 1 month
• March 13, 2017

For Psoriatic Arthritis "I rate Apremilast on a 50/50 basis. I've just finished the 2-week starter pack and have had a wide lot of side effects on and off. But today - BAM! Headache, nausea, uncontrollable bowel... I've only just gone back to work after 2 months of chronic PSA and now have had to blow out today because of this drug. As a total plus, though, my psoriasis has halved in such a short time, so I'm going to persevere with this med. Wish me luck :)"

• Por...
• Taken for less than 1 month
• June 6, 2015

For Plaque Psoriasis "I have been using this medication only a week, I am now on full dosage and have had hardly any side effects, which was my main concern. The specialist said I could expect nausea, diarrhea, and some headaches, and possibly vomiting. He also made me aware that these effects would wear off after a couple of weeks of my body adjusting to the medication. I have actually had a couple of small headaches (took paracetamol), a touch of nausea, only when I was moving up to the next level on tablets, and more regular bowel movements...not a bad thing. I feel fine, the psoriasis is starting to clear already :-)"

• Iva...
• Taken for less than 1 month
• January 14, 2023

Apremilast for Plaque Psoriasis "I have to say that this is not for me. Side effects after the second day: diarrhea, headache, nausea, and today was the worst day after 10 days. I had diarrhea and vomiting at the same time! lol, it was really disgusting, so I'm gonna stop taking this. I did not notice an improvement in my psoriasis. I will continue to use my betamethasone ointments. Good luck!"

• Sta...
• July 10, 2015

Apremilast for Plaque Psoriasis "Psoriasis started to clear in just a couple of weeks; however, nausea and uncontrollable bowel issues have been an ongoing negative, but the 35 lb weight loss is the silver lining."

• Str...
• June 15, 2015

Apremilast for Psoriatic Arthritis "I'm only on day 7 of this medication, so too early to tell, but I'm experiencing severe nausea, as expected."

• Aur...
• Taken for 1 to 6 months
• October 23, 2019

Apremilast for Plaque Psoriasis "Was on Otezla for 6 months. No help for the psoriasis, instead, I was constantly nauseous during the whole time."

• Anonymous
• December 23, 2022

Apremilast for Plaque Psoriasis "I was sick (severe nausea) for 1-2 hours after every Otezla dose for 6 months, then I decided to stop taking Otezla. After stopping, I flared worse than before I started the medication."

• LuJ...
• September 23, 2017

Apremilast for Plaque Psoriasis "Tried this med for 6 days; had to stop. Almost went crazy! Severe depression, cried at the drop of a hat, extremely nauseous, IBS, and so irritable, it nearly cost my relationship!"