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User Reviews for Acetaminophen / oxycodone to treat Pain

Also known as: Percocet, Percocet 5/325, Percocet 10/325, Percocet 7.5/325, Percocet 7.5/500, Percocet 2.5/325, Oxycet, Xolox Prolate Percocet 10/650 Nalocet Primlev …show all brand names

Acetaminophen / oxycodone has an average rating of 8.3 out of 10 from a total of 400 ratings for the treatment of Pain. 81% of reviewers reported a positive effect, while 10% reported a negative effect.

Acetaminophen/oxycodone Rating Summary

8.3/10 average rating

400 ratings from 430 user reviews.

Compare all 1438 medications used in the treatment of Pain.

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Reviews for Acetaminophen / oxycodone

Eliz · Taken for 1 to 2 years September 8, 2019

Percocet 10/325 (acetaminophen / oxycodone): “I have cancer pain and I've gotten generics from other companies and when I got the RP 10 325 (Rhodes Pharmaceuticals L.P.?) ones they do not work at all! I contacted the pharmaceutical company and filed a complaint I've also contacted the FDA and filed a complaint notified my pharmacist and filed a complaint”

1 / 10
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pam4726 October 28, 2008

Percocet (acetaminophen / oxycodone): “I've used percocet for pain in the past (several nasty dental surgeries). I couldn't help but notice one user's comment that it helped with her depression. I have social anxiety and generalized anxiety disorder and whenever I take percocet I feel absolutely normal again. I become very focused and energetic (much less scatter-brained and terrified of everything) and am very productive. I have told my psycho pharmacologist this but didn't seem to get anywhere with it. I know that you can't take this drug forever but it's too bad there isn't something that can be learned from this. Interesting that someone else feels the same way.”

10 / 10
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Lauts · Taken for less than 1 month October 30, 2020

“This drug feels like a placebo. There is zero effective. I just had shoulder surgery, and am in pain, and have a bottle of nothing. Rite Aid filled it and basically said Oh Well. I've had a number of surgeries and have been prescribed this before so I am familiar with its effect on me. Even doubling the dose this time has had no effect at all. Nothing. I have calls out to the FDA and Rhodes. This cannot be allowed to continue.”

1 / 10
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dntgiveup1 · Taken for 1 to 6 months August 3, 2015

Percocet (acetaminophen / oxycodone): “Extreme aching throbbing lower back pain. Tried lyrica, cymbalta, tramadol, ultram, vicodine, flexyril, deseryl, trasadone, imiprimine, just to name a few with no relief and in most cases felt worse. Had 2 injections at L4/L5 that did nothing to relieve the pain and was finally given 10/325 percocet 1 twice a day but i find that 1/2 twice a day allows me to function and provides relief so I can actually feel like doing things. I am disappointed that this drug is taboo I guess because of the potential for abuse, but anyone with real pain is not taking it for the narcotic affect but so they can lead a normal life. I think the FDA and physicians that try to steer clear of prescribing it need to experience living with pain.”

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Victim · Taken for 10 years or more October 20, 2019

Percocet 10/325 (acetaminophen / oxycodone): “Camber brand is garbage do not except it tell them you want another brand tell your doctor it causes headaches high blood pressure does nothing to the pain they’re allowed to reduce 20% of the active medicine and generics this seems to be reduced 75%”

1 / 10
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SDTP2012 August 7, 2018

“How sad that we hope the FDA cares or Walgreens cares. s. I am a SPSDT, severe pain sufferer denied treatment (SPSDT)due to the laws by State of TN. My diagnosis: bone cancer. The FDA should be called out for lack of compassion and cruelty to those that are sick, scared, and suffering. Disabled children and the elderly are SPS too. Do these anti-opioid fanatics consider that they may develop cancer or heart disease later in life? Will they regret it when they can't get pain relief? I wonder and I pray they do not suffer. I would not wish it on anyone. Severe pain, day in and day out, no physical or mental escape, no sleep...it's horrible. SPSDT go to the streets for relief from torture. It is not about "addiction" people, it is about the unbearable suffering. Cruelty to other humans on the earth.”

10 / 10
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Jimmy · Taken for 10 years or more February 4, 2021

“Well I don’t understand how chamber, Rhodes, and aneal and other company can give these acetaminophen with oxycodone out they do not work! I live in Louisiana and they used to carry Avalon and they work, now no one can get them at all ! Got to find something that works before I end up at the methadone clinic! I sure that what the government want us to take and to take weed ! What has happened to our health care ?”

1 / 10
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Karen4851 July 20, 2008

Percocet (acetaminophen / oxycodone): “I had heavy dental work done and the doctor gave me Percocet. I also suffer from depression. The percocet did wonders for my depression. It made me feel like myself again. I plan on telling my shrink about this tomorrow morning. I know I can't continue to take this medicine but there may be a clue about percocet and depression. I don't feel high, just normal.”

8 / 10
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jaimem September 12, 2008

Percocet (acetaminophen / oxycodone): “I had back surgery (Laminectemy of L4, L5 and S4 , 8 inch titanium rod w/7 screws)in October 2006 plus I have severe Fibromyalgia and although Percocet makes me a little sleepy, this is the first time in 4 years that I feel relatively pain free. About 5 doctors were afraid of giving me anything stronger than regular Vicoden because of habit forming. Who cared if I couldn't walk or participate in activities. I finally found a doctor that was willing to help! Sometimes they give dogs more pallative care than humans. I should have gone to a vetenerian instead. ”

10 / 10
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tibby22 · Taken for less than 1 month June 19, 2021

“I am filing a complaint with the FDA, this generic Percocet doesn't work at all. I have only ever gotten pain meds for dental work. Percocet has always worked, not this time, This one takes an hour to work and the pain relief only lasts for 30 minutes, then I have to wait another 30 minutes before I can take another one. Every other time I have had dental work I would take one Percocet every 4-6 hours, now I am taking a pill every two hours and I am still in pain for an hour an a half of that time. There is no way this is the same medication. I think Advil would have worked better.”

1 / 10
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jr · Taken for less than 1 month September 3, 2018

Percocet (acetaminophen / oxycodone): “I paid $275.00 for 120 percocet pills from CVS in ravenna ohio. I just had back surgery and have not been on pain meds before surgery. I was prescribed 10/325 generic, they started to kick in about 20 minutes later, they only lasted about three hours. They are the worst pain meds I have ever taken , the rb percocet are garbage, call your pharmacy ask who their supplier is of that med, they usually will tell you. I asked the pharmacy if anyone else had complained they said yes, but the person said the get these pills really cheap. You would think all the money cvs makes they would care more for their customers, please beware.”

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Greg · Taken for 1 to 6 months May 13, 2019

“I’ve been taking Oxycodone w /APAP 10/325 for 6 mos for chronic pain. I have had all prescriptions filled at Walgreens and had no complaints until now. My most recent prescription seems to possibly be fake. Previous pills were hard and shiny, and worked well, this batch is dull, soft and chalky and I can’t feel them working. All numbers stamped on pills as well as shape and size are the same but these are garbage. I’m taking them back to Walgreens tomorrow and having them refilled elsewhere. Possibly bootleg ???”

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threesixes November 29, 2008

Percocet (acetaminophen / oxycodone): “I am taking Percocet 10/325mg five times daily for breakthrough pain with Ms-Contin 30 mg twice daily, and 60 mg at night. I am taking them due to a past near fatal car wreck that almost left me totally crippled. Taking these medicines have really given me my life back. I also agree that it actually does help with depression; as some people have mentioned on this site. I suffer from deep depression, and since taking these medicines it is like the depression is totally gone. Thumbs up to the caring Pain Management Doctors and these two medicines. Worked wonders for me.”

10 / 10
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OSHCat · Taken for 1 to 2 years August 14, 2019

“Publix pharmacy just changed from Alvogen Genetic acetaminophen / Oxycodone to Chambers generic and I have had terrible reactions. Headaches, nausea, elevated heart rate, irregular heartbeat, racing thoughts, unable to sleep, chills, hot flashes and sweats. I had to STOP taking after one week. The pharmacy told me they have had numerous complaints. They are trying to get another manufacturer again. In the interim my Health Insurance provider is trying to locate a pharmacy who carries the Alvogen Genetic.”

1 / 10
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jackson October 16, 2019

Percocet (acetaminophen / oxycodone): “I have taken percs before and the last time I picked up my script the pharmacy told me these may be made outside the US. Noticing some of the comments and people getting sick is it possible that those symptoms cause the ill effect from being made outside the country? Just an opinion...”

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Anonymous January 17, 2020

“BIG MIKE---YES, I'm on this horrible M523 acetaminophen/oxycodone after suffering stomach complications. Kings County Hospital was too paranoid to allow me pain relievers so I had to ask my pain management doctor for my back who usually prescribes me oxycodone 5mg every month with no issues or running out of prescription. Unfortunately I started using more of my back pain meds to deal with stomach pain (NOTE: oxycodone does not cause stomach issues as NSAIDS may cause issues long term.) I begged my pain management doctor for a new prescription so he gave me 10 mg of the M523....it made me drowsy and lethargic while I still dealt with pain. Finally through time my stomach healed on it's own THANK GOODNESS. So now I'm going take back the heap of fake pills back to Walgreens and just settle with my usual prescription which is due today. DO NOT ACCEPT ANY PRESCRIPTION FROM Mallinckrodt INC! BEWARE.”

1 / 10
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Anonymous March 3, 2020

Percocet (acetaminophen / oxycodone): “Taking 5/325 acetaminophen & oxycodone every 6 hrs for intense tooth pain after oral surgery. Had never taken an opioid before, this was truly a lifesaver for me. Took my pain from a 10 to a 3. Also taking 3 Ibuprofen every 6 hrs (alternating). My doc says if pain is brutal I can go to 10mg every 6 hrs, thats 2 pills. Im trying to avoid that but suffice to say this stuff works quite well for me. Pop a stool softener once in awhile.”

9 / 10
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Morgan Danielle. June 7, 2014

Percocet (acetaminophen / oxycodone): “Percocet was a life saver for me. I was on Vicodin prior, and they didn't help whatsoever. I had taken Vicodin for like, 5 years. I was at the point where I had to take like SIX Vicodin to get relief. People acted like I was a seeker but I'm definitely not, I just got a high tolerance because the dose was never changed. Percocet helps so much more! If I'm in 10/10 pain, I can take like one and a half or two - and it'll take it down to a 3-4/10. I have quite a few health issues, my main issue is a back injury from cheerleading and a bladder issue called interstitial cystitis. It's excruciating. Since changing to Percocet, I went from every month or two, being in the ER... to, no ER visits!”

9 / 10
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Anonymous October 24, 2008

Percocet (acetaminophen / oxycodone): “I'm 30 years old and I have 3 degenerated discs in my spine and a pinched sciatic nerve. Until I found percocet my life was horrible. I couldn't even sleep it hurt so bad. Now I can live my life again.”

9 / 10
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Patience September 11, 2018

Percocet 10/325 (acetaminophen / oxycodone): “This camber brand is real different. As lots of others have said I don't think they are as effective as they are labeled, maybe underdosed. They say blue but are white with blue specks, water turns blue when they dissolve in it. I was reading on a dye the FDA said a company could not use was trying to be used, I think this company is using it anyway and not putting full amounts of the ingredients.”

5 / 10
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motherandwife June 2, 2008

Percocet (acetaminophen / oxycodone): “I am a 26 year old woman and I have 2 kids. I was in a really bad wreck in December 2006. I was rear ended at 55mph while I was sitting still in a construction zone. My doctor put me on percocet for the neck and back pain. It felt like a wounder drug to me. I have had a lot of medical problems in my life and I still do, it as been one surgery after another and percocet is the best pain medication that I have ever taken. Percocet is the best.”

10 / 10
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Sugarsharon · Taken for 2 to 5 years December 9, 2018

Percocet 10/325 (acetaminophen / oxycodone): “I have been on Percocet for four years and it is an excellent pain reliever until I recently started getting one called RP10/325. It is a lousy Pill they're like taking an aspirin they do nothing for my pain I hear everyone at my pharmacy is complaining about this medication I don’t understand why the pharmacy keeps getting them. I’m trying to find a new pharmacy and I don’t know where to go help.”

8 / 10
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DaveLaw · Taken for less than 1 month May 2, 2015

Percocet (acetaminophen / oxycodone): “Took the pill every six hours for two weeks after shoulder surgery to deal with the immense pain. It worked! Then I stopped one day. Big mistake. The withdrawal took a week and I felt like going to the ER. No one told me to taper off. The pain became unbearable again especially after physical therapy and now I only take one an hour before PT. Bottom line, it works but is a narcotic so addiction CAN happen and withdrawal must be executed carefully.”

9 / 10
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Foxtrotz · Taken for 10 years or more June 24, 2016

Percocet (acetaminophen / oxycodone): “Whenever I am in pain, this is my go to medication. I have a back, shoulder, neck, and foot injury and by rights should be on this medicine for chronic pain. For right now I only take it very rarely so that it works when needed, to avoid a tolerance. Because I am not working I am able to deal with the pain, however when I go back to work, I will most likely have to go on this medication or a similar one full time. The only thing I do not like is the fact that many of these narcotic pain medications contain tylenol, asperin, or ibuprofin which makes your kidneys, liver and other organs go through unnecessary stresses. I prefer it to be just oxycodone and if I need the synergy of tylenol I can add it on my own.”

10 / 10
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ramassist2 November 7, 2009

Percocet (acetaminophen / oxycodone): “Have battled post traumatic osteoarthritis for years. Over the counter medicines not too effective and I have been through all of the other classes of prescription pain relievers. My doctor prescribed Nucynta (synthetic opioid), made me feel tired and most of the pain was still present. Finally switched me to Percocet, it is absolutely amazing. Although there is some pain occasionally for the most part it is gone and I have much more energy and my depression has lifted. I have also found that most doctor's resist prescribing it and take you through round after round of various pain medicines. With Percocet, I found that it works and I can finally take control of my pain. My days are filled with more vitality and enthusiasm.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.