Skip to main content

Acetaminophen / oxycodone for Pain User Reviews

Brand names: Percocet, Prolate, Oxycet, Nalocet, Percocet 5/325, Percocet 10/650 Percocet 7.5/500 Percocet 2.5/325 Percocet 10/325 Percocet 7.5/325 Primlev Xolox …show all brand names

Acetaminophen / oxycodone has an average rating of 8.1 out of 10 from a total of 405 reviews for the treatment of Pain. 79% of reviewers reported a positive experience, while 11% reported a negative experience.

Acetaminophen/oxycodone rating summary

8.1 average rating out of 10

405 ratings from 434 user reviews.

Compare all 1458 medications used in the treatment of Pain.

10
39%
9
27%
8
13%
7
5%
6
2%
5
2%
4
0%
3
2%
2
1%
1
8%

Reviews for Acetaminophen / oxycodone

  • Eliz
  • Taken for 1 to 2 years
  • September 8, 2019

Percocet 10/325 (acetaminophen / oxycodone) "I have cancer pain and I've gotten generics from other companies, and when I got the RP 10/325 (Rhodes Pharmaceuticals L.P.?) ones, they do not work at all! I contacted the pharmaceutical company and filed a complaint. I've also contacted the FDA and filed a complaint, notified my pharmacist, and filed a complaint."

1 / 10
Was this helpful?YesNo
360 Report
  • dntgi...
  • Taken for 1 to 6 months
  • August 3, 2015

Percocet (acetaminophen / oxycodone) "Extreme aching throbbing lower back pain. Tried Lyrica, Cymbalta, Tramadol, Ultram, Vicodin, Flexeril, Desyrel, Trazodone, Imipramine, just to name a few with no relief, and in most cases felt worse. Had 2 injections at L4/L5 that did nothing to relieve the pain and was finally given 10/325 Percocet 1 twice a day, but I find that 1/2 twice a day allows me to function and provides relief so I can actually feel like doing things. I am disappointed that this drug is taboo, I guess because of the potential for abuse, but anyone with real pain is not taking it for the narcotic effect but so they can lead a normal life. I think the FDA and physicians that try to steer clear of prescribing it need to experience living with pain."

Was this helpful?YesNo
442 Report
  • pam
  • October 28, 2008

Percocet (acetaminophen / oxycodone) "I've used Percocet for pain in the past (several nasty dental surgeries). I couldn't help but notice one user's comment that it helped with her depression. I have social anxiety and generalized anxiety disorder, and whenever I take Percocet, I feel absolutely normal again. I become very focused and energetic (much less scatter-brained and terrified of everything) and am very productive. I have told my psychopharmacologist this but didn't seem to get anywhere with it. I know that you can't take this drug forever, but it's too bad there isn't something that can be learned from this. Interesting that someone else feels the same way."

10 / 10
Was this helpful?YesNo
522 Report
  • Lauts
  • Taken for less than 1 month
  • October 30, 2020

"This drug feels like a placebo. There is zero effectivity. I just had shoulder surgery and am in pain, and have a bottle of nothing. Rite Aid filled it and basically said, 'Oh well.' I've had a number of surgeries and have been prescribed this before, so I am familiar with its effect on me. Even doubling the dose this time has had no effect at all. Nothing. I have reached out to the FDA and Rhodes. This cannot be allowed to continue."

1 / 10
Was this helpful?YesNo
147 Report
  • Victim
  • Taken for 10 years or more
  • October 20, 2019

Percocet 10/325 (acetaminophen / oxycodone) "Camber brand is garbage. Do not accept it. Tell them you want another brand. Tell your doctor it causes headaches, high blood pressure, and does nothing to the pain. They're allowed to reduce 20% of the active medicine in generics. This seems to be reduced by 75%."

1 / 10
Was this helpful?YesNo
141 Report

Are you taking this medicine?

  • SDTP
  • August 7, 2018

"How sad that we hope the FDA cares or Walgreens cares. I am a SPSDT, severe pain sufferer denied treatment (SPSDT) due to the laws by the State of TN. My diagnosis is bone cancer. The FDA should be called out for lack of compassion and cruelty to those who are sick, scared, and suffering. Disabled children and the elderly are SPS too. Do these anti-opioid fanatics consider that they may develop cancer or heart disease later in life? Will they regret it when they can't get pain relief? I wonder and I pray they do not suffer. I would not wish it on anyone. Severe pain, day in and day out, no physical or mental escape, no sleep...it's horrible. SPSDT go to the streets for relief from torture. It is not about 'addiction', people, it is about the unbearable suffering. Cruelty to other humans on the earth."

10 / 10
Was this helpful?YesNo
154 Report
  • Karen
  • July 20, 2008

Percocet (acetaminophen / oxycodone) "I had heavy dental work done, and the doctor gave me Percocet. I also suffer from depression. The Percocet did wonders for my depression. It made me feel like myself again. I plan on telling my shrink about this tomorrow morning. I know I can't continue to take this medicine, but there may be a clue about Percocet and depression. I don't feel high, just normal."

8 / 10
Was this helpful?YesNo
227 Report
  • jrano
  • Taken for less than 1 month
  • September 3, 2018

Percocet (acetaminophen / oxycodone) "I paid $275.00 for 120 Percocet pills from CVS in Ravenna, Ohio. I just had back surgery and have not been on pain meds before surgery. I was prescribed 10/325 generic, they started to kick in about 20 minutes later, but they only lasted about three hours. They are the worst pain meds I have ever taken. The RB Percocet are garbage. Call your pharmacy and ask who their supplier is for that medication, they usually will tell you. I asked the pharmacy if anyone else had complained, and they said yes, but the person said they get these pills really cheap. You would think with all the money CVS makes, they would care more for their customers. Please beware."

Was this helpful?YesNo
98 Report
  • jaimem
  • September 12, 2008

Percocet (acetaminophen / oxycodone) "I had back surgery (Laminectomy of L4, L5, and S4, 8-inch titanium rod with 7 screws) in October 2006, plus I have severe Fibromyalgia. Although Percocet makes me a little sleepy, this is the first time in 4 years that I feel relatively pain-free. About 5 doctors were afraid of giving me anything stronger than regular Vicodin because of habit-forming. Who cared if I couldn't walk or participate in activities. I finally found a doctor that was willing to help! Sometimes they give dogs more palliative care than humans. I should have gone to a veterinarian instead."

10 / 10
Was this helpful?YesNo
198 Report
  • jackson
  • October 16, 2019

Percocet (acetaminophen / oxycodone) "I have taken Percocet before, and the last time I picked up my script, the pharmacy told me these may be made outside the US. Noticing some of the comments and people getting sick, is it possible that those symptoms cause the ill effect from being made outside the country? Just an opinion..."

Was this helpful?YesNo
68 Report
  • Morgan...
  • June 7, 2014

Percocet (acetaminophen / oxycodone) "Percocet was a lifesaver for me. I was on Vicodin prior, and they didn't help whatsoever. I had taken Vicodin for like 5 years. I was at the point where I had to take like SIX Vicodin to get relief. People acted like I was a seeker, but I'm definitely not. I just got a high tolerance because the dose was never changed. Percocet helps so much more! If I'm in 10/10 pain, I can take like one and a half or two, and it'll take it down to a 3-4/10. I have quite a few health issues, my main issue is a back injury from cheerleading and a bladder issue called interstitial cystitis. It's excruciating. Since changing to Percocet, I went from every month or two, being in the ER, to no ER visits!"

9 / 10
Was this helpful?YesNo
115 Report
  • three...
  • November 29, 2008

Percocet (acetaminophen / oxycodone) "I am taking Percocet 10/325mg five times daily for breakthrough pain with Ms-Contin 30 mg twice daily, and 60 mg at night. I am taking them due to a past near-fatal car wreck that almost left me totally crippled. Taking these medicines has really given me my life back. I also agree that it actually does help with depression, as some people have mentioned on this site. I suffer from deep depression, and since taking these medicines it is like the depression is totally gone. Thumbs up to the caring Pain Management Doctors and these two medicines. Worked wonders for me."

10 / 10
Was this helpful?YesNo
152 Report
  • Greg
  • Taken for 1 to 6 months
  • May 13, 2019

"I’ve been taking oxycodone with APAP 10/325 for 6 months for chronic pain. I have had all prescriptions filled at Walgreens and had no complaints until now. My most recent prescription seems to possibly be fake. Previous pills were hard and shiny and worked well. This batch is dull, soft, and chalky, and I can’t feel them working. All numbers stamped on pills, as well as shape and size, are the same, but these are garbage. I’m taking them back to Walgreens tomorrow and having them refilled elsewhere. Possibly bootleg."

Was this helpful?YesNo
63 Report
  • Jimmy
  • Taken for 10 years or more
  • February 4, 2021

"Well, I don’t understand how Chamber, Rhodes, and Aneal and other companies can give these acetaminophen with oxycodone out, they do not work! I live in Louisiana, and they used to carry Avalon, and they worked. Now, no one can get them at all! Got to find something that works before I end up at the methadone clinic! I’m sure that’s what the government wants us to take and to take weed! What has happened to our health care?"

1 / 10
Was this helpful?YesNo
46 Report
  • OSHCat
  • Taken for 1 to 2 years
  • August 14, 2019

"Publix Pharmacy just changed from Alvogen Generic acetaminophen / oxycodone to Chambers Generic, and I have had terrible reactions. Headaches, nausea, elevated heart rate, irregular heartbeat, racing thoughts, unable to sleep, chills, hot flashes, and sweats. I had to stop taking after one week. The pharmacy told me they have had numerous complaints. They are trying to get another manufacturer again. In the interim, my health insurance provider is trying to locate a pharmacy that carries the Alvogen Generic."

1 / 10
Was this helpful?YesNo
57 Report
  • DaveLaw
  • Taken for less than 1 month
  • May 2, 2015

Percocet (acetaminophen / oxycodone) "Took the pill every six hours for two weeks after shoulder surgery to deal with the immense pain. It worked! Then I stopped one day. Big mistake. The withdrawal took a week, and I felt like going to the ER. No one told me to taper off. The pain became unbearable again, especially after physical therapy, and now I only take one an hour before PT. Bottom line, it works but is a narcotic so addiction CAN happen, and withdrawal must be executed carefully."

9 / 10
Was this helpful?YesNo
88 Report
  • Patie...
  • September 11, 2018

Percocet 10/325 (acetaminophen / oxycodone) "This camber brand is really different. As lots of others have said, I don't think they are as effective as they are labeled, maybe underdosed. They say blue, but are white with blue specks, water turns blue when they dissolve in it. I was reading on a dye the FDA said a company could not use was trying to be used. I think this company is using it anyway and not putting full amounts of the ingredients."

5 / 10
Was this helpful?YesNo
57 Report
  • Anonymous
  • January 17, 2020

"BIG MIKE---YES, I'm on this horrible M523 acetaminophen/oxycodone after suffering stomach complications. Kings County Hospital was too paranoid to allow me pain relievers, so I had to ask my pain management doctor for my back, who usually prescribes me oxycodone 5 mg every month with no issues or running out of prescription. Unfortunately, I started using more of my back pain meds to deal with stomach pain (NOTE: oxycodone does not cause stomach issues as NSAIDs may cause issues long term.) I begged my pain management doctor for a new prescription, so he gave me 10 mg of the M523....it made me drowsy and lethargic while I still dealt with pain. Finally, through time, my stomach healed on its own, THANK GOODNESS. So now I'm going to take back the heap of fake pills back to Walgreens and just settle with my usual prescription, which is due today. DO NOT ACCEPT ANY PRESCRIPTION FROM Mallinckrodt INC! BEWARE."

1 / 10
Was this helpful?YesNo
47 Report
  • Sugar...
  • Taken for 2 to 5 years
  • December 9, 2018

Percocet 10/325 (acetaminophen / oxycodone) "I have been on Percocet for four years, and it is an excellent pain reliever until I recently started getting one called RP10/325. It is a lousy pill, they're like taking an aspirin, they do nothing for my pain. I hear everyone at my pharmacy is complaining about this medication. I don’t understand why the pharmacy keeps getting them. I’m trying to find a new pharmacy, and I don’t know where to go. Help."

8 / 10
Was this helpful?YesNo
55 Report
  • Anonymous
  • October 24, 2008

Percocet (acetaminophen / oxycodone) "I'm 30 years old, and I have 3 degenerated discs in my spine and a pinched sciatic nerve. Until I found Percocet, my life was horrible. I couldn't even sleep, it hurt so bad. Now I can live my life again."

9 / 10
Was this helpful?YesNo
113 Report
  • Foxtr...
  • Taken for 10 years or more
  • June 24, 2016

Percocet (acetaminophen / oxycodone) "Whenever I am in pain, this is my go-to medication. I have a back, shoulder, neck, and foot injury and by rights should be on this medicine for chronic pain. For right now, I only take it very rarely so that it works when needed, to avoid a tolerance. Because I am not working, I am able to deal with the pain, however, when I go back to work, I will most likely have to go on this medication or a similar one full-time. The only thing I do not like is the fact that many of these narcotic pain medications contain Tylenol, aspirin, or ibuprofen, which makes your kidneys, liver, and other organs go through unnecessary stresses. I prefer it to be just oxycodone, and if I need the synergy of Tylenol, I can add it on my own."

10 / 10
Was this helpful?YesNo
69 Report
  • Anonymous
  • March 3, 2020

Percocet (acetaminophen / oxycodone) "Taking 5/325 acetaminophen & oxycodone every 6 hrs for intense tooth pain after oral surgery. Had never taken an opioid before, this was truly a lifesaver for me. Took my pain from a 10 to a 3. Also taking 3 Ibuprofen every 6 hrs (alternating). My doc says if pain is brutal, I can go to 10 mg every 6 hrs, that's 2 pills. I'm trying to avoid that, but suffice to say this stuff works quite well for me. Pop a stool softener once in a while."

9 / 10
Was this helpful?YesNo
40 Report
  • Lucia
  • Taken for less than 1 month
  • November 7, 2014

Percocet (acetaminophen / oxycodone) "This medication was a lifesaver after cancer surgery. I took one pill every six hours as needed, 10/325. I was able to sleep, walk, and eat after surgery. I am not taking it anymore, my doctor gave me sixty. I have thirty left, I will use those if I ever need them again."

Was this helpful?YesNo
71 Report
  • Kissa
  • Taken for 6 months to 1 year
  • May 11, 2015

Percocet 10/325 (acetaminophen / oxycodone) "I have been on Percocet 10/325 for 6 months now, and I personally couldn't have asked for my pain management doctor to have prescribed anything better. I suffer from bad lumbar and left knee pain. My pain kept me at the doctor's office and in emergency rooms, and finally I have relief."

9 / 10
Was this helpful?YesNo
66 Report
  • mothe...
  • June 2, 2008

Percocet (acetaminophen / oxycodone) "I am a 26-year-old woman and I have 2 kids. I was in a really bad wreck in December 2006. I was rear-ended at 55 mph while I was sitting still in a construction zone. My doctor put me on Percocet for the neck and back pain. It felt like a wonder drug to me. I have had a lot of medical problems in my life, and I still do, it has been one surgery after another, and Percocet is the best pain medication that I have ever taken. Percocet is the best."

10 / 10
Was this helpful?YesNo
97 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.