Acetaminophen/oxycodone Patient Tips
Medically reviewed by C. Fookes, BPharm. Last updated on Nov 13, 2018.
How it works
- Acetaminophen/oxycodone is a combination of two different pain-relief medicines with two different mechanisms of action.
- Experts aren't sure exactly how acetaminophen works but suspect it blocks a specific type of cyclooxygenase (COX) enzyme, located mainly in the brain. Oxycodone binds to specific receptors known as mu opioid receptors that block pain signals on their way to the brain.
- Acetaminophen/oxycodone belongs to the group of medicines known as combination narcotic analgesics. It may also be called a combination opioid analgesic.
- Effective for the management of moderate-to-moderately severe pain unresponsive to other treatment options.
- The combination is more effective than either drug alone.
- Available in tablet and oral solution forms, extended-release forms (Xartemis XR), as well as some cost-saving generic versions.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- Drowsiness or dizziness which may impair reaction skills and affect a person's ability to drive or operate machinery (oxycodone component). Avoid alcohol.
- Stomach upset including nausea and vomiting, and constipation (oxycodone component). Laxatives may be required.
- Excessive dosages of acetaminophen can lead to liver injury or death. Care must be taken not to take additional acetaminophen from other sources.
- Unlike NSAID pain relievers like ibuprofen, acetaminophen does not have any appreciable anti-inflammatory action.
- Oxycodone is habit forming and potentially abusable. The combination of acetaminophen and oxycodone should only be used short-term at the lowest effective dose when other nonopioid analgesics are not effective. Legitimate supplies of products containing oxycodone may be sought out by drug seekers.
- Abrupt discontinuation of any oxycodone-containing medication in a person who has become physically dependent on it may lead to a withdrawal syndrome and symptoms such as restlessness, pupil dilation, watery eyes and a runny nose, sweating, muscle aches, insomnia, irritability and gastrointestinal complaints. Babies born to mothers who are physically dependent on oxycodone will also be physically dependent.
- Rarely, serious, life-threatening, breathing problems may occur attributable to the oxycodone component. The risk is greater with higher dosages of acetaminophen/oxycodone, in people with pre-existing respiratory disease, in seniors or the frail, or in those taking other medications that cause respiratory depression (such as benzodiazepines).
- Interaction or overdosage may also cause serotonin syndrome. Symptoms include mental status changes such as agitation, hallucinations, coma, or delirium; a fast heart rate; dizziness; flushing; muscle tremor or rigidity; and stomach symptoms (including nausea, vomiting, and diarrhea).
- May not be suitable for people with pre-existing respiratory depression or respiratory disease, with seizure disorders or a head injury, people with gastrointestinal obstruction, or recent use of monoamine oxidase inhibitors.
- Not suitable for people younger than 18 years.
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- May be taken with or without food.
- Take as directed by your doctor. Do not increase the dosage without his or her advice.
- Call emergency services if you experience any breathing difficulties, wheezing, or facial swelling.
- Tell your doctor if you think you have become addicted to this combination drug.
- Short-term use is recommended. Do not exceed the prescribed dosage.
- Tell your doctor if you have severe uncontrolled asthma, other breathing problems, or an intestinal blockage; you may not be able to use this medicine.
- Call your doctor if you experience nausea or vomiting, stomach pain, itching, yellowing of your skin or eyes (jaundice), or dark (brown) urine, or light-colored stools.
- Keep out of reach of children and pets because even one dose of this combination narcotic can be fatal.
- Avoid alcohol as the combination of alcohol and acetaminophen/oxycodone can increase side effects such as sedation and respiratory depression.
- Xartemis XR is not interchangeable with other acetaminophen/oxycodone products because of differences in the frequency of administration.
- Swallow extended-release acetaminophen/oxycodone (Xartemis XR) whole.
- Do not cut, crush, chew or attempt to dissolve Xartemis XR because rapid release and absorption of a potentially fatal dose of oxycodone may occur.
Response and Effectiveness
- The maximum effect of oxycodone component is reached in 1.8 hours and the duration of activity lasts for 3-4 hours. Acetaminophen reaches its maximum effect within 30-60 minutes of administration and its analgesic effect lasts around 3 to 4 hours.
- Oxycodone and Acetaminophen [Package Insert]. Revised 06/2018. Mallinckrodt, Inc. https://www.drugs.com/pro/oxycodone-and-acetaminophen-tablets.html
- Xartemis XR (oxycodone and acetaminophen extended release) [Package Insert]. Revised 09/2017. Mallinckrodt, Inc. https://www.drugs.com/pro/xartemis-xr.html
More about acetaminophen/oxycodone
- Acetaminophen/oxycodone Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 645 Reviews
- Drug class: narcotic analgesic combinations
- FDA Alerts (4)
- Acetaminophen and oxycodone
- Oxycodone and Acetaminophen Capsules and Tablets
- Oxycodone and Acetaminophen Extended-Release Tablets
- Oxycodone and Acetaminophen Oral Solution
- Oxycodone and acetaminophen (Advanced Reading)
Related treatment guides
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use acetaminophen/oxycodone only for the indication prescribed.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.