Acetaminophen / dichloralphenazone / isometheptene mucate and Sleepy: What Users Say

• Liv...
• Taken for 10 years or more
• March 20, 2017

Acetaminophen / dichloralphenazone / isometheptene mucate for Headache "As of this review (Spring 2017), only one company makes it (Macoven Pharma). It is the best migraine treatment for me, whatever variation of name it is dispensed as: 'Midrin', 'Commonly known as Midrin', 'Epidrin', 'isometheptene-dichloralphenazone-acetaminophen', 'Isometh/Dich/Apap 65-100-325.' At the onset of a migraine, I take 2 capsules of Midrin, and 20-30 minutes later, the migraine just starts to disappear. Makes me sleepy - that's the only downside, and one I can manage. Usually, the first dose is enough, occasionally, I take one more Midrin capsule an hour later. I went through years trying out various Rx's, shots, and treatments with my doctor, but once we tried Midrin, I got my life back. Difficult to find a pharmacy to supply, but worth it!"

• Anonymous
• November 1, 2010

Acetaminophen / dichloralphenazone / isometheptene mucate for Headache "I opted to try Midrin because of its low side effects compared to the triptans. It works best when taken at the first sign of a headache, and I find that a cup of coffee not only speeds things along, it helps ward off the sleepy side effect. A piece of bread helps with the nausea that comes with a bad migraine. The best thing my doctor suggested was to keep a headache diary in order to find out what my migraine triggers are. That was a big help! Now I know what to avoid-anything with MSG, also called 'natural flavor,' and artificial sweeteners were THE WORST!"

• Lad...
• Taken for 10 years or more
• August 16, 2018

Acetaminophen / dichloralphenazone / isometheptene mucate for Headache "Midrin is the only medication that I have had success with to combat a migraine. I could take it at the onset of a migraine to stop the pain dead in its tracks. I'm currently taking Sumatriptan (generic Imitrex), which makes me sleepy enough to sleep through the pain but doesn't always elevate the pain. I've been researching Midrin today to learn whether or not it will ever be available again for migraines, but I'm not having much luck. Posting here to see if anyone knows the status and to ask others what meds they used if Imitrex didn't work for them."

• Liv...
• Taken for 10 years or more
• March 10, 2017

For Headache "Midrin, Epidrin, isometheptene-dichloralphenazone-acetaminophen, Isometh/Dich/Apap 65-100-325, whatever variation of name it is dispensed as, it is the best migraine treatment for me. It must be administered early into the headache, or it is much less effective. That's the only downside, and one I've managed to deal with successfully over many years now. I take 2 capsules at onset and one more tablet each hour after as needed (usually a total of three capsules is enough!). The only side effect is it makes me sleepy. I went through two years trying out various Rx's, shots, treatments with my doctor, but once we tried Midrin, I got my life back. The difficulty getting it lately has me jumping through hoops, and the price skyrocketed, but it's worth it."