Acetaminophen / dichloralphenazone / isometheptene mucate User Reviews & Ratings

• Moj...
• Taken for 10 years or more
• August 29, 2019

For Headache "I've experienced migraines my entire life, and I've been taking Midrin for about 30 years now. I don't have any side effects, and I'm able to function with the med, and with the headache. As essential personnel 24/7 for law enforcement, Midrin kept me going and productive. It is extremely frustrating that it has gone on and off the market many times over the years. It's even more frustrating when it's such a common medicine, and now it's not available at all. I've tried every other migraine med, and I've been to countless neurologists, and Midrin is the only thing that actually works, and every time. Come on FDA and pharmaceutical companies. Let's get Midrin back into production and back into the hands of those of us that rely on it."

• Lyr...
• June 27, 2019

For Headache "I have had a “classic migraine” condition for 40 years, and a neurologist prescribed Midrin for my TIA-like symptoms. Neither Imitrex nor other triptan meds work to avert the aura, loss of vision, numbness, or speech difficulties, but a single Midrin capsule worked within 15 minutes to reduce or eliminate a full-on, persistent migraine headache. Please bring it back!!"

• Dix...
• Taken for 10 years or more
• July 13, 2019

For Headache "I have had migraines all of my life (at least 50% of my days on Earth), but was not diagnosed until I was 40. I still remember the pain and extreme nausea in my high school days. I went through 2 years of trial and error with a neurologist. Midrin is the only thing that worked. Midrin decreased the pain and nausea and let me function at a normal level. I could work, exercise, and do social activities just like a normal person. Now my alternatives are stronger, potentially addictive medications. Way to go, FDA. Try some common sense, please, and 'allow' the millions of us to have relief from migraines and live our lives. You allow drugs that cause permanent physical damage to remain on the market but ban this drug that has been around for decades without incident. You have no clue. Or they aren't making billions of dollars off this drug, so why bother."

• Yad...
• Taken for 10 years or more
• July 26, 2019

For Headache "I cannot tell you how devastated I am that I can no longer get Midrin. I hate Imitrex, Midrin does not affect me poorly like other medications do. I can perform my duties at work, and it takes the edge off of my migraine. As soon as I get an aura, I take a Midrin, and within 15 minutes the edge is gone. Now a severe migraine, I will have to take up to 4 a day, but... I'm down to my last 2 pills, and I just want to cry. Come on, FDA!!!!!"

• ret...
• January 27, 2019

For Headache "I have had migraines for 25 years. My neurologist just prescribed Midrin - I see that many can't get it from the pharmacy anymore, which is what he told me. Well, the way around that is: he gave me a script to have a compound pharmacy (which there are many) make the Midrin for me. They will make the exact formula in capsule form. It will not be covered by insurance, but I really don't care. When you have migraine pain, money does not matter, which we all know. I am taking it to the compound pharmacy tomorrow (I live in Phoenix, AZ) to have it made. Go to your doctor and ask for a script to have it made - look for a compound pharmacy in your area and get your migraine help back. My doctor said it would cost me about $100 to have it made. If $100 will stop that pain, I am there. I have to say that I am feeling a whole lot better about this script thanks to your reviews! Hope you all go have this made for you. Oh, what was the substitute people were taking?"

• Lin...
• Taken for 10 years or more
• May 15, 2019

For Headache "How on earth can they discontinue this medication that has helped me and others tremendously?! If you do not suffer from actual migraines (I have migraines with aura), then you have absolutely no idea what life is like for us. I have been taking this medicine for 20 years and now have nothing else that I am compatible with to use!"

• Anonymous
• Taken for 10 years or more
• May 31, 2019

For Headache "I have suffered from the symptoms of migraine headaches for over 25 years and prescribed many popular migraine prescriptions without relief, but Midrin 'always' works. Two Midrin capsules, and within 30 minutes, full symptom relief, but on occasion, 1 extra capsule may be required to achieve full relief. For those who don't understand, at the onset of a migraine or waking up at night to a full-blown migraine, the headache symptoms are torturous and usually include nausea for hours until the inevitable violent vomiting. Bring back my Midrin."

• Maz...
• Taken for 2 to 5 years
• May 8, 2019

For Headache "I have been getting 40 Botox injections every ten weeks in my head and temples for the last 5 years to treat migraines that I have suffered with for 30+ years. I have taken EVERY available medication and vitamin offered to combat them and suffered from being further triggered, allergic reactions, and becoming too incapacitated to care for my children or work. Midrin has been the ONLY breakthrough medication to help me reduce the length and severity of the migraines I get between treatments. Why is it gone? It is the only medication that allows me to function between my treatments. It has really impaired my abilities in so many ways. It is WRONG to disarm us strong and struggling individuals of some peace and health. Clearly, the medical decision-makers have never gotten a migraine, least of all 15+ monthly."

• Mac...
• October 22, 2019

For Headache "I have been using Midrin for over 25 years for my severe migraines. I have been to 5 doctors, 3 neurologists, multiple MRIs, and about 25+ different medications. Come to find out the only medication that works for me is an old medication (Midrin). I used to have 3-4 migraines a week. Without Midrin, I would have never been able to get a career job. Now that I have gotten older, my migraines have decreased to about 1 migraine a month. I'm very lucky to have them less than when I was younger. Now I find myself down to 5 pills left and can't find them anywhere. Can't get them or get them compounded. After I use my last 5 pills, my migraines will last 3 days or so without Midrin. With Midrin, they last 2-4 hours. If I can't get Midrin, I'm afraid I will lose my job. I feel for anyone that is in my same situation or worse than me. They need to get it back on the market or just let us get it compounded again."

• Pam...
• Taken for 1 to 2 years
• July 27, 2019

For Headache "I had my doctor write a prescription for the acetaminophen/dichloralphenazone/isometheptene mucate formula instead of the name of the drug. Then I took that to a compounding pharmacy and had them make it for me. The only downside is that my insurance won't cover the compounded drug, and it is pricey. But for the relief it gives, it's worth it. I am going to see if I can have the doctor write separate scripts for the components. Even though it means taking multiple pills, the insurance should cover it."

• imd...
• Taken for 10 years or more
• December 18, 2018

For Headache "I have had migraines since 2008. I went through every kind of pill imaginable until my neurologist prescribed Midrin - finally something that actually worked! Then, after a couple of years, it was nowhere to be found, and therefore I suffered horribly trying to get by with Naproxen, which is basically useless. Last year, I was able to get Midrin again - even though I have to pay $4 a pill for it - it's cheaper than a trip to the ER for the 'really bad ones.' Fast forward to a couple of months ago, I went from 2 different Rite Aids to then 2 different Walgreens, getting my Midrin filled is always a rigmarole. Today, I called to see if my prescription was ready, and they said Midrin and equivalents were discontinued! I am freaking out - this is the ONLY thing that works for my bad migraines. Please, FDA, figure out what you need to and get this stuff back on the shelves!"

• ham...
• Taken for 1 to 6 months
• March 13, 2021

For Headache "I get terrible headaches due to cervical arthritis for several years now, I have tried many different headache meds, including Botox injections. Nothing works. Recently, a new neurologist I have seen prescribed Midrin. After searching the area where I reside, I found a compounding pharmacy where I get this wonder drug made. It has helped me get my life back again. I urge everyone who cannot get this drug to write to the FDA to let them know how important it is to get this drug back to pharmacies throughout the country. Also, I urge everyone to contact your state senators to make Midrin payable through Medicare and other prescription plans, as it is rather expensive. This medication is a godsend."

• Syb...
• Taken for 10 years or more
• November 30, 2018

For Headache "It was the best cheap drug for migraines. Nobody wants to make it now because it doesn’t make pharmaceuticals enough money. What is the FDA thinking? All those years, no deaths, and I don’t know of any serious side effects. And it worked for many people. Even the migraine headache clinic wrote scripts for it all the time. Because it worked. Now the FDA markets all kinds of drugs that cause serious side effects and death. I understand the rules for the FDA have changed and are more stringent now. So new studies, new manufacturers, and prices are jacked up. And worst of all, we still get migraines with no Midrin."

• Kra...
• Taken for 10 years or more
• January 11, 2020

For Headache "I've had hemiplegic migraines since I was 9 years old. I'm now 53. Midrin is the only medication that works for me. It completely shuts down a migraine within 30 minutes. Although they are not as frequent as they were when I was younger, I still get one or two a year, and without the Midrin, I will be in bed for 2 or 3 days, in severe pain, throwing up and not able to speak. The Midrin I have now is 5 years old and doesn't work very well. I'm afraid of what will happen the next time I get a migraine."

• Liv...
• Taken for 10 years or more
• March 20, 2017

For Headache "As of this review (Spring 2017), only one company makes it (Macoven Pharma). It is the best migraine treatment for me, whatever variation of name it is dispensed as: 'Midrin', 'Commonly known as Midrin', 'Epidrin', 'isometheptene-dichloralphenazone-acetaminophen', 'Isometh/Dich/Apap 65-100-325.' At the onset of a migraine, I take 2 capsules of Midrin, and 20-30 minutes later, the migraine just starts to disappear. Makes me sleepy - that's the only downside, and one I can manage. Usually, the first dose is enough, occasionally, I take one more Midrin capsule an hour later. I went through years trying out various Rx's, shots, and treatments with my doctor, but once we tried Midrin, I got my life back. Difficult to find a pharmacy to supply, but worth it!"

• Dyi...
• Taken for 6 months to 1 year
• February 11, 2021

For Headache "I suffer from glioblastoma (a rare form of cancer). I was prescribed Midrin, and it helped relieve the pressure and onset of pain. Now I am close to death. Thanks to the FDA. The pain is intolerable. I would prefer Midrin over my fentanyl and morphine dosages any day. How many more people have to die or understand the pain we all go through."

• She...
• Taken for 10 years or more
• August 22, 2012

For Headache "I was diagnosed with severe headaches at the age of three. My doctors concluded I was born with severe headaches and was finally able to explain my pain at age three. I have been taking Midrin since 1988, and I thank my doctor for prescribing it. Every time a new headache medicine came out, I tried it, none of them did anything to relieve my pain ever. Yes, narcotic medicines help to lessen the pain until the pain ceases. Midrin is the only medicine I have ever taken that actually repairs the problem. I take 2 Midrin and a Flexeril at the onset, or as soon as I can, and one Midrin every hour to a maximum of 5 in a 24-hour period until I feel relief coming on. Midrin has never failed me, ever."

• Poo...
• Taken for 10 years or more
• February 18, 2020

For Headache "Midrin or the generic has worked wonders for me for over 30 years with no side effects. Nothing else I tried has been as helpful. I take it as soon as the aura starts, and it stops it within 15 minutes. I found a compounding pharmacy in Wildwood, Florida, that is making it for me. Thank goodness!"

• Pos...
• September 26, 2018

For Headache "I have suffered from terrible migraines for many, many years. Tried many different things from my family doctor and nothing would take away my headaches. Finally, my doctor sent me to a neurologist, and she put me on Midrin, and it was a miracle! I took my first Midrin pill, and just like that, (snap), my headache goes away! Usually only need one to get rid of it, on rare occasions, had to take another. It never failed me, and I had zero side effects and did not ever feel high or impaired in any way whatsoever. And it is not addictive! And I agree with the other lady that commented on this medication, we need to start a petition or send letters or call the surgeon general or someone in the government to stop this insanity of not permitting this long-time, proven safe and effective and non-addictive medicine that has hardly any side effects (in most cases, no side effects), tried and true for decades migraine. Let's get medication back in pharmacies in America!"

• Jen...
• December 10, 2018

For Headache "I was born with migraines. So I tried many, many, many different migraine meds. Only Midrin relieved my pain. And I had no side effects. With the other meds, my throat was so dry I couldn’t swallow. And my heart had palpitations, and I felt like a zombie. Please, FDA, put Midrin back on the pharmacies. You have no idea that Midrin has the least harmful side effects."

• lop...
• July 15, 2015

For Headache "This is by far the best headache medication I've ever used. I've tried Fioricet and Imitrex, and neither worked well. Fioricet made me feel as if I were high, and the Imitrex made me itch all over and my heart race. The only thing with Midrin is that it needs to be taken as soon as you feel a headache coming on, or it won't work well once your headache is full-blown."

• Meg...
• Taken for 1 to 6 months
• August 6, 2013

For Headache "I have sporadic hemiplegic migraines, and I was prescribed Midrin and Imitrex. Midrin is the only medication I've ever had that truly helped the migraines! I don't know if it was taken off the market and put back on, but I just got my first prescription for it about 2 months ago and have since refilled it once. So I know it's available where I am."

• Anonymous
• February 18, 2012

For Headache "If taken soon enough, Midrin works wonders for the migraines I get. I have tried dozens of medications over the last 10 years. It is so sad that the FDA has banned Midrin from being sold. I think all of us need to create a petition or something to show that this medication works for us and we need it back!"

• tpa...
• Taken for 6 months to 1 year
• September 20, 2016

For Headache "I was having severe migraines for about 5 months. The doctor tried every medication available. I would only buy 4 because I didn't want to waste money on the whole prescription and it not work. Imitrex made me so sick! I had remembered from the early 90s when I would get cluster headaches and the doctor put me on Midrin. Out of the blue, I asked the doctor to try this again. He didn't think it was available, but my pharmacy said they could compound it. Again, I bought 4 pills, thinking I was wasting my money but desperate. Bam... migraine stopped within 20 minutes of taking. Sometimes, it takes a second dose if I have a severe one. But, I feel it is under control now. I have fibromyalgia, the migraines are a sensory issue: smells, sounds."

• Gab...
• Taken for 1 to 2 years
• May 8, 2014

For Headache "I've had migraines for 15 years. Imitrex made me sick, so my neurologist prescribed Midrin. It's the only medication that actually relieves my migraines completely. I know they don't have the brand name Midrin, but in some places you can get the generic-Isometheptene/dichloralphenazone/acetaminophen. It has all the same ingredients and works great."