Generic Name: Perphenazine (per FEN a zeen)
Medically reviewed on July 4, 2018
- There is a higher chance of death in older adults who take perphenazine for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This medicine is not approved to treat mental problems caused by dementia.
Uses of Perphenazine:
- It is used to treat upset stomach and throwing up.
- It is used to treat schizophrenia.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Perphenazine?
For all patients taking perphenazine:
- If you have an allergy to perphenazine or any other part of perphenazine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Blood problems, bone marrow disease, brain problems, liver disease, or low blood cell count.
- If you are very sleepy.
- If you have recently drunk a lot of alcohol or taken a big amount of drugs that may slow your actions like phenobarbital or some pain drugs like oxycodone.
- If your child is younger than 12 years of age. Do not give perphenazine to a child younger than 12 years of age.
This is not a list of all drugs or health problems that interact with perphenazine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take perphenazine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Perphenazine?
- Tell all of your health care providers that you take perphenazine. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how perphenazine affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- If you have been taking perphenazine on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking perphenazine all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of getting an infection. Deadly infections have rarely happened. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Talk with your doctor.
- A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
- Avoid drinking alcohol while taking perphenazine.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take perphenazine.
- This medicine may cause the results of some pregnancy tests to be wrong. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Dizziness, sleepiness, and feeling less stable may happen with perphenazine. These may lead to falling. Broken bones or other health problems can happen from falling. Talk with the doctor.
- If you are 65 or older, use perphenazine with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using perphenazine while you are pregnant.
- Taking perphenazine in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Perphenazine) best taken?
Use perphenazine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food. Take with food if it causes an upset stomach.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- If you are planning to harm yourself or the want to harm yourself gets worse.
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Very bad dizziness or passing out.
- Very bad headache.
- Chest pain or pressure.
- Shakiness, trouble moving around, or stiffness.
- Not able to pass urine.
- Feeling very tired or weak.
- Any unexplained bruising or bleeding.
- Change in how you act.
- Change in eyesight, eye pain, or very bad eye irritation.
- Slow heartbeat.
- Pale skin.
- Very hard stools (constipation).
- Enlarged breasts.
- Nipple discharge.
- Sex problems like lowered interest in sex or ejaculation problems.
- For women, no period.
- Some people who take perphenazine may get a very bad muscle problem called tardive dyskinesia. This muscle problem may not go away even if perphenazine is stopped. Sometimes, signs may lessen or go away over time after perphenazine is stopped. The risk of tardive dyskinesia may be greater in people with diabetes and in older adults, especially older women. The risk is also greater the longer you take perphenazine or with higher doses. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.
What are some other side effects of Perphenazine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Dry mouth.
- Hard stools (constipation).
- Feeling sleepy.
- Loose stools (diarrhea).
- Not hungry.
- Upset stomach or throwing up.
- Stuffy nose.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Perphenazine?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about perphenazine, please talk with your doctor, nurse, pharmacist, or other health care provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about perphenazine
- Perphenazine Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 18 Reviews
- Drug class: phenothiazine antiemetics
Other brands: Trilafon