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Parnate

Generic Name: Tranylcypromine (tran il SIP roe meen)
Brand Name: Parnate

Medically reviewed on May 2, 2018.

Warning

  • Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take Parnate (tranylcypromine) need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • This medicine is not approved for use in children. Talk with the doctor.
  • Some foods and drinks like cheese and red wine may cause very bad and sometimes deadly effects, such as sudden high blood pressure. Talk with your doctor about your risk for these effects. Get a list of foods and drinks to avoid. Avoid these foods and drinks for at least 2 weeks after Parnate (tranylcypromine) is stopped.

Uses of Parnate:

  • It is used to treat low mood (depression). It is most often given after other drugs have failed to help.

What do I need to tell my doctor BEFORE I take Parnate?

  • If you have an allergy to tranylcypromine or any other part of Parnate (tranylcypromine).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have a tumor on the adrenal gland called pheochromocytoma or another type of tumor called paraganglioma.
  • If you are taking or will be taking another drug like this one.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Parnate (tranylcypromine) like certain cough or cold remedies, diet pills, drugs for mental or mood problems like low mood (depression), or stimulants like amphetamine. There also may need to be some time between taking these drugs and Parnate (tranylcypromine). There are many drugs that must not be taken for some time between stopping one drug and starting the other.
  • If you are breast-feeding. Do not breast-feed while you take Parnate (tranylcypromine).

This is not a list of all drugs or health problems that interact with Parnate (tranylcypromine).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Parnate (tranylcypromine) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Parnate?

  • Tell all of your health care providers that you take Parnate (tranylcypromine). This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If Parnate (tranylcypromine) is stopped, your doctor will tell you when to start taking Parnate (tranylcypromine) again after your surgery or procedure.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Parnate (tranylcypromine) affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • High blood pressure has happened with Parnate (tranylcypromine). Sometimes, this has been deadly. Have your blood pressure checked as you have been told by your doctor.
  • Chance of seizures may be higher. Talk with the doctor.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Do not use OTC drugs that have dextromethorphan, phenylephrine, or pseudoephedrine. They may cause very high blood pressure when used with Parnate (tranylcypromine).
  • If you are taking Parnate (tranylcypromine) and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
  • Avoid drinking alcohol while taking Parnate (tranylcypromine).
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • Avoid use of caffeine (for example, tea, coffee, cola) and chocolate. Use with Parnate (tranylcypromine) may cause high blood pressure, nervousness, shakiness, a fast heartbeat, and anxiety.
  • Do not stop taking Parnate (tranylcypromine) all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop Parnate (tranylcypromine), you will want to slowly stop it as ordered by your doctor.
  • If you stop taking Parnate (tranylcypromine), tell your doctor if you have any bad effects.
  • If you are 65 or older, use Parnate (tranylcypromine) with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Parnate (tranylcypromine) while you are pregnant.

How is this medicine (Parnate) best taken?

Use Parnate (tranylcypromine) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • To gain the most benefit, do not miss doses.
  • Keep taking Parnate (tranylcypromine) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
  • Signs of low blood sugar like dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating.
  • Seizures.
  • A very bad and sometimes deadly health problem called serotonin syndrome may happen if you take Parnate (tranylcypromine) with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.

What are some other side effects of Parnate?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling sleepy.
  • Headache.
  • Hard stools (constipation).
  • Not able to sleep.
  • Dry mouth.
  • Feeling nervous and excitable.
  • Shakiness.
  • Blurred eyesight.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Parnate?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Parnate (tranylcypromine) is refilled. If you have any questions about Parnate (tranylcypromine), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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