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Midazolam Nasal Spray

Generic name: Midazolam Nasal Spray [ MID-aye-zoe-lam ]
Brand name: Nayzilam
Drug class: Benzodiazepines

Medically reviewed by Last updated on Apr 20, 2023.


  • This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
  • This medicine is a benzodiazepine. The use of a benzodiazepine drug along with opioid drugs has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and death. Opioid drugs include drugs like codeine, oxycodone, and morphine. Opioid drugs are used to treat pain and some are used to treat cough. Talk with the doctor.
  • If you are taking midazolam nasal spray with an opioid drug, get medical help right away if you feel very sleepy or dizzy; if you have slow, shallow, or trouble breathing; or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.

Uses of Midazolam Nasal Spray:

What do I need to tell my doctor BEFORE I take Midazolam Nasal Spray?

  • If you have an allergy to midazolam or any other part of midazolam nasal spray.
  • If you are allergic to midazolam nasal spray; any part of midazolam nasal spray; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have glaucoma.
  • If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with midazolam nasal spray, like certain drugs that are used for HIV, infections, or seizures.

This is not a list of all drugs or health problems that interact with midazolam nasal spray.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take midazolam nasal spray with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Midazolam Nasal Spray?

  • Tell all of your health care providers that you take midazolam nasal spray. This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine may be habit-forming with long-term use.
  • This medicine has a risk of abuse and misuse. Use midazolam nasal spray only as you were told by your doctor. Tell your doctor if you have ever abused or been addicted to any drugs or alcohol.
  • This medicine is not meant for regular, daily use. Talk with the doctor.
  • Avoid driving and doing other tasks that call for you to be alert until the effects of midazolam nasal spray wear off and you feel fully awake. You may also need to wait for 1 full day after your dose.
  • Use care moving around after getting midazolam nasal spray. You may need help with standing and walking until the effects of midazolam nasal spray have worn off.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • Avoid grapefruit and grapefruit juice.
  • If you are 65 or older, use midazolam nasal spray with care. You could have more side effects.
  • Use with care in children. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking midazolam nasal spray, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Midazolam Nasal Spray) best taken?

Use midazolam nasal spray as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • If you will be using midazolam nasal spray at home, your doctor or nurse will teach you how to use it.
  • Do not take midazolam nasal spray by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • Do not test or prime before using.
  • If the seizure cluster has not stopped 10 minutes after you use midazolam nasal spray, a second dose may be used if your doctor has told you to. Do not use more than 2 doses for the same seizure.
  • If using more than 1 dose, switch nostrils with each dose.
  • If the seizure does not stop after using midazolam nasal spray, get medical help right away.

What do I do if I miss a dose?

  • This medicine is used on an as needed basis. Do not use more often than told by the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Shakiness.
  • Twitching.
  • Very bad dizziness or passing out.
  • Feeling agitated.
  • Trouble controlling body movements.
  • If seizures are new or worse after starting midazolam nasal spray.
  • Like other drugs that may be used for seizures, midazolam nasal spray may rarely raise the risk of suicidal thoughts or actions. The risk may be higher in people who have had suicidal thoughts or actions in the past. Call the doctor right away about any new or worse signs like depression; feeling nervous, restless, or grouchy; panic attacks; or other changes in mood or behavior. Call the doctor right away if any suicidal thoughts or actions occur.

What are some other side effects of Midazolam Nasal Spray?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Nose or throat irritation.
  • Headache.
  • Memory problems or loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Midazolam Nasal Spray?

  • Store at room temperature.
  • Store midazolam nasal spray in the blister pack that it comes in. Do not open until ready to use. Do not use if the nasal spray is damaged.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time midazolam nasal spray is refilled. If you have any questions about midazolam nasal spray, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.