Skip to main content

Medroxyprogesterone Injection (Intramuscular)

Generic name: Medroxyprogesterone Injection (intramuscular) [ me-DROKS-ee-proe-JES-te-rone ]
Brand name: Depo-Provera
Drug classes: Contraceptives, Hormones / antineoplastics, Progestins

Medically reviewed by Last updated on Mar 22, 2024.


  • Using medroxyprogesterone injection (intramuscular) for birth control or endometriosis pain may cause bone loss. Bone loss is greater the longer the drug is used. It is not known what the effects will be on bones when used in teenaged and young adult women. Do not use medroxyprogesterone injection (intramuscular) for longer than 2 years unless other options will not work or cannot be used.

Uses of Medroxyprogesterone Injection:

What do I need to tell my doctor BEFORE I take Medroxyprogesterone Injection?

For all reasons other than cancer treatment:

This is not a list of all drugs or health problems that interact with medroxyprogesterone injection (intramuscular).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take medroxyprogesterone injection (intramuscular) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Medroxyprogesterone Injection?

How is this medicine (Medroxyprogesterone Injection) best taken?

Use medroxyprogesterone injection (intramuscular) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What do I do if I miss a dose?

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

What are some other side effects of Medroxyprogesterone Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Medroxyprogesterone Injection?

Consumer Information Use and Disclaimer

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.