Medically reviewed by Drugs.com. Last updated on Aug 22, 2023.
- Do not take if you are pregnant. Use during pregnancy may cause birth defects or loss of the unborn baby. If you get pregnant or plan on getting pregnant while taking lisinopril and hydrochlorothiazide, call your doctor right away.
Uses of Lisinopril and Hydrochlorothiazide:
- It is used to treat high blood pressure.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Lisinopril and Hydrochlorothiazide?
- If you have an allergy to lisinopril, hydrochlorothiazide, or any other part of lisinopril and hydrochlorothiazide.
- If you are allergic to lisinopril and hydrochlorothiazide; any part of lisinopril and hydrochlorothiazide; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have ever had a very bad or life-threatening reaction called angioedema. Signs may be swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; unusual hoarseness.
- If you are taking dofetilide.
- If you have kidney disease.
- If you are not able to pass urine.
- If you are taking a drug that has aliskiren in it and you also have diabetes or kidney problems.
- If you have taken a drug that has sacubitril in it in the last 36 hours.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with lisinopril and hydrochlorothiazide.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take lisinopril and hydrochlorothiazide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Lisinopril and Hydrochlorothiazide?
- Tell all of your health care providers that you take lisinopril and hydrochlorothiazide. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how lisinopril and hydrochlorothiazide affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Check your blood pressure as you have been told.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take lisinopril and hydrochlorothiazide.
- If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
- If you are on a low-salt or salt-free diet, talk with your doctor.
- Talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
- Low white blood cell counts have happened with captopril, a drug like this one. This may lead to more chance of getting an infection. Most of the time, this has happened in people with kidney problems, mainly if they have certain other health problems. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
- If you take cholestyramine or colestipol, talk with your pharmacist about how to take them with lisinopril and hydrochlorothiazide.
- Watch for gout attacks.
- If you have lupus, lisinopril and hydrochlorothiazide can make your lupus active or get worse. Tell your doctor right away if you get any new or worse signs.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. This may lead to low blood pressure.
- A severe and sometimes deadly reaction called angioedema has happened. The chance of angioedema may be higher in black patients.
- If you are 65 or older, use lisinopril and hydrochlorothiazide with care. You could have more side effects.
How is this medicine (Lisinopril and Hydrochlorothiazide) best taken?
Use lisinopril and hydrochlorothiazide as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Take lisinopril and hydrochlorothiazide at the same time of day.
- Keep taking lisinopril and hydrochlorothiazide as you have been told by your doctor or other health care provider, even if you feel well.
- This medicine may cause you to pass urine more often. To keep from having sleep problems, try not to take too close to bedtime.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Chest pain.
- Cough that does not go away.
- Very bad belly pain.
- A burning, numbness, or tingling feeling that is not normal.
- Any skin change.
- This medicine can cause certain eye problems. If left untreated, this can lead to lasting eyesight loss. If eye problems happen, signs like change in eyesight or eye pain most often happen within hours to weeks of starting lisinopril and hydrochlorothiazide. Call your doctor right away if you have these signs.
- Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Lisinopril and Hydrochlorothiazide?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Lisinopril and Hydrochlorothiazide?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about lisinopril and hydrochlorothiazide, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
More about hydrochlorothiazide / lisinopril
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (78)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: ACE inhibitors with thiazides
- En español
- Hydrochlorothiazide and lisinopril drug information
- Lisinopril and hydrochlorothiazide (Advanced Reading)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.