Generic name: Hydrocodone and Acetaminophen Liquid [ hye-droe-KOE-done-& a-seet-a-MIN-oh-fen ]
Brand names: Hycet, Lortab, Zyfrel
Drug class: Narcotic analgesic combinations
Medically reviewed by Drugs.com. Last updated on Feb 25, 2023.
- This medicine is a strong pain drug that can put you at risk for addiction, abuse, and misuse. Misuse or abuse of hydrocodone and acetaminophen liquid can lead to overdose and death. Talk with your doctor.
- You will be watched closely to make sure you do not misuse, abuse, or become addicted to hydrocodone and acetaminophen liquid.
- This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
- The chance of very bad and sometimes deadly breathing problems may be greater when you first start hydrocodone and acetaminophen liquid or anytime your dose is raised.
- Even one dose of hydrocodone and acetaminophen liquid may be deadly if it is taken by someone else or by accident, especially in children. If hydrocodone and acetaminophen liquid is taken by someone else or by accident, get medical help right away.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- This medicine has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs that may make you drowsy or slow your actions. This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines may be used to treat many health problems like anxiety, trouble sleeping, or seizures. If you have questions, talk with your doctor.
- Many drugs interact with hydrocodone and acetaminophen liquid and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use hydrocodone and acetaminophen liquid with all of your drugs.
- Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
- Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
- This medicine has acetaminophen in it. Liver problems have happened with the use of acetaminophen. Sometimes, this has led to a liver transplant or death. Most of the time, liver problems happened in people taking more than 4,000 mg (milligrams) of acetaminophen in a day. People were also often taking more than 1 drug that had acetaminophen.
- Be sure that you know how to measure your dose. Dosing errors can lead to accidental overdose and death. If you have any questions, talk with your doctor or pharmacist.
- Using hydrocodone and acetaminophen liquid for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
Uses of Hydrocodone and Acetaminophen Liquid:
- It is used to ease pain.
What do I need to tell my doctor BEFORE I take Hydrocodone and Acetaminophen Liquid?
- If you are allergic to hydrocodone and acetaminophen liquid; any part of hydrocodone and acetaminophen liquid; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
- If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
- If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
- If you are taking any of these drugs: Linezolid or methylene blue.
This is not a list of all drugs or health problems that interact with hydrocodone and acetaminophen liquid.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydrocodone and acetaminophen liquid with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Hydrocodone and Acetaminophen Liquid?
- Tell all of your health care providers that you take hydrocodone and acetaminophen liquid. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how hydrocodone and acetaminophen liquid affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Allergic reactions have happened with hydrocodone and acetaminophen liquid. Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.
- If you have been taking hydrocodone and acetaminophen liquid for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if hydrocodone and acetaminophen liquid stops working well. Do not take more than ordered.
- Long-term or regular use of opioid drugs like hydrocodone and acetaminophen liquid may lead to dependence. Lowering the dose or stopping hydrocodone and acetaminophen liquid all of a sudden may cause a greater risk of withdrawal or other severe problems. Talk to your doctor before you lower the dose or stop hydrocodone and acetaminophen liquid. You will need to follow your doctor’s instructions. Tell your doctor if you have more pain, mood changes, thoughts of suicide, or any other bad effects.
- Avoid taking other products that have acetaminophen in them. Check labels closely. Too much acetaminophen may cause liver problems.
- Follow the directions exactly. Do not take more acetaminophen in a day than directed. If you do not know how much acetaminophen you can take in a day, ask your doctor or pharmacist. Some people may take up to 4,000 mg (milligrams) in a day if told to do so by the doctor. Some people (like people with liver problems and children) should take less acetaminophen. Call your doctor right away if you have taken too much acetaminophen in a day, even if you feel well.
- Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
- Taking an opioid drug like hydrocodone and acetaminophen liquid may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
- This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking hydrocodone and acetaminophen liquid.
- If you are 65 or older, use hydrocodone and acetaminophen liquid with care. You could have more side effects.
- Use with care in children. Talk with the doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking hydrocodone and acetaminophen liquid, call your doctor right away.
- Tell your doctor if you are breast-feeding or plan to breast-feed. This medicine passes into breast milk and may harm your baby.
How is this medicine (Hydrocodone and Acetaminophen Liquid) best taken?
Use hydrocodone and acetaminophen liquid as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food. Take with food if it causes an upset stomach.
- Measure liquid doses carefully. Use the measuring device that comes with hydrocodone and acetaminophen liquid. If there is none, ask the pharmacist for a device to measure hydrocodone and acetaminophen liquid.
- Do not use a household teaspoon or tablespoon to measure hydrocodone and acetaminophen liquid. Doing so could lead to the dose being too high.
- Do not take hydrocodone and acetaminophen liquid with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take hydrocodone and acetaminophen liquid.
What do I do if I miss a dose?
- If you take hydrocodone and acetaminophen liquid on a regular basis, take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times hydrocodone and acetaminophen liquid is taken on an as needed basis. Do not take more often than told by the doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Very bad dizziness or passing out.
- Clammy skin.
- Sweating a lot.
- Feeling confused.
- Trouble walking.
- Severe constipation or stomach pain. These may be signs of a severe bowel problem.
- Not able to pass urine or change in how much urine is passed.
- Hearing loss.
- Change in hearing.
- Chest pain or pressure.
- Fast or slow heartbeat.
- Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
- Mood changes.
- Trouble passing urine.
- Change in eyesight.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- A severe and sometimes deadly problem called serotonin syndrome may happen if you take hydrocodone and acetaminophen liquid with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.
What are some other side effects of Hydrocodone and Acetaminophen Liquid?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Upset stomach or throwing up.
- Stomach pain or heartburn.
- Feeling dizzy, sleepy, tired, or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Hydrocodone and Acetaminophen Liquid?
- Store at room temperature. Do not refrigerate or freeze.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time hydrocodone and acetaminophen liquid is refilled. If you have any questions about hydrocodone and acetaminophen liquid, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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