Diphenhydramine and Ibuprofen
Medically reviewed on May 2, 2018.
Uses of Diphenhydramine and Ibuprofen:
- It is used to help you fall asleep and stay asleep when you are not able to sleep because of minor aches and pains.
What do I need to tell my doctor BEFORE I take Diphenhydramine and Ibuprofen?
For all patients taking diphenhydramine and ibuprofen:
- If you have an allergy to diphenhydramine, ibuprofen, or any other part of diphenhydramine and ibuprofen.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you do not have time to get a full night's sleep.
- If you are taking any other NSAID.
- If you are pregnant or may be pregnant. Do not take diphenhydramine and ibuprofen if you are in the third trimester of pregnancy. You may also need to avoid diphenhydramine and ibuprofen at other times during pregnancy. Talk with your doctor to see when you need to avoid taking diphenhydramine and ibuprofen during pregnancy.
- If your child is younger than 12 years of age. Do not give diphenhydramine and ibuprofen to a child younger than 12 years of age.
This is not a list of all drugs or health problems that interact with diphenhydramine and ibuprofen.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take diphenhydramine and ibuprofen with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Diphenhydramine and Ibuprofen?
- Tell all of your health care providers that you take diphenhydramine and ibuprofen. This includes your doctors, nurses, pharmacists, and dentists.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- Do not take diphenhydramine and ibuprofen for longer than you were told by your doctor.
- Avoid driving and doing other tasks or actions that call for alertness while you take diphenhydramine and ibuprofen. Talk with your doctor.
- Avoid drinking alcohol while taking diphenhydramine and ibuprofen.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Do not use with other products that have diphenhydramine.
- This medicine may raise the chance of heart and blood vessel side effects like heart attack and stroke. If these happen, they can be deadly. The risk of these side effects may be greater if you have heart disease or risks for heart disease. However, the risk may also be raised in people who do not have heart disease or risks for heart disease. The risk of these health problems can happen as soon as the first weeks of using diphenhydramine and ibuprofen and may be greater with higher doses or with long-term use. Do not use diphenhydramine and ibuprofen right before or after bypass heart surgery.
- This medicine may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleeding. The risk is greater in older people. The risk is also greater in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs. Talk with the doctor.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.
- The chance of heart attack and heart-related death is raised in people taking drugs like this one after a recent heart attack. People taking drugs like this one after a first heart attack were also more likely to die in the year after the heart attack compared with people not taking drugs like this one. Talk with the doctor.
- If you are taking aspirin to help prevent a heart attack, talk with your doctor.
- Use with care in children. Talk with the doctor.
- If you are 60 or older, use diphenhydramine and ibuprofen with care. You could have more side effects.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking diphenhydramine and ibuprofen, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Diphenhydramine and Ibuprofen) best taken?
Use diphenhydramine and ibuprofen as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food. Take with food if it causes an upset stomach.
- Take diphenhydramine and ibuprofen at bedtime.
What do I do if I miss a dose?
- If you take diphenhydramine and ibuprofen on a regular basis, take a missed dose as soon as you think about it.
- If you will not be able to get a full night's sleep (at least 7 hours) after taking the missed dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times diphenhydramine and ibuprofen is taken on an as needed basis. Do not take more often than told by the doctor.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Chest pain or pressure.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very bad dizziness or passing out.
- Any unexplained bruising or bleeding.
- Very bad belly pain.
- Black, tarry, or bloody stools.
- Throwing up blood or throw up that looks like coffee grounds.
What are some other side effects of Diphenhydramine and Ibuprofen?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling nervous and excitable.
- Feeling sleepy.
- Belly pain or heartburn.
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Diphenhydramine and Ibuprofen?
- Store at room temperature.
- Protect from heat.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about diphenhydramine and ibuprofen, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about diphenhydramine/ibuprofen
- Diphenhydramine/ibuprofen Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 1 Review – Add your own review/rating
- Drug class: analgesic combinations