Diphenhydramine/ibuprofen Interactions
There are 759 drugs known to interact with diphenhydramine/ibuprofen, along with 19 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 114 are major, 631 are moderate, and 14 are minor.
- View all 759 medications that may interact with diphenhydramine/ibuprofen
- View diphenhydramine/ibuprofen alcohol/food interactions (2)
- View diphenhydramine/ibuprofen disease interactions (19)
Most frequently checked interactions
View interaction reports for diphenhydramine / ibuprofen and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall (amphetamine / dextroamphetamine)
- B-12 (cyanocobalamin)
- B-12 (cyanocobalamin)
- Bactrim (sulfamethoxazole / trimethoprim)
- Bactrim (sulfamethoxazole / trimethoprim)
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- BuSpar (buspirone)
- BuSpar (buspirone)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Latuda (lurasidone)
- Latuda (lurasidone)
- Lexapro (escitalopram)
- Lexapro (escitalopram)
- Lorazepam Intensol (lorazepam)
- Lorazepam Intensol (lorazepam)
- Maxalt-MLT (rizatriptan)
- Maxalt-MLT (rizatriptan)
- Percocet (acetaminophen / oxycodone)
- Percocet (acetaminophen / oxycodone)
- Prilosec (omeprazole)
- Prilosec (omeprazole)
- Seroquel (quetiapine)
- Seroquel (quetiapine)
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
Diphenhydramine/ibuprofen alcohol/food interactions
There are 2 alcohol/food interactions with diphenhydramine / ibuprofen.
Diphenhydramine/ibuprofen disease interactions
There are 19 disease interactions with diphenhydramine / ibuprofen which include:
- depression
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- PKU
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about diphenhydramine / ibuprofen
- diphenhydramine/ibuprofen consumer information
- Compare alternatives
- Reviews (23)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
