Generic Name: Medroxyprogesterone Injection (400 mg/mL) (meh DROX ee pro JESS tuh rone)
Brand Name: Depo-Provera
Medically reviewed on April 4, 2018.
- Using Depo-Provera (medroxyprogesterone injection (400 mg/mL)) for birth control or pain caused by endometriosis may cause bone loss. Bone loss is greater the longer the drug is used. It is not known what the effects will be on bones when used in teenaged and young adult women.
- Do not use Depo-Provera (medroxyprogesterone injection (400 mg/mL)) for birth control for a long time unless other options will not work.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
Uses of Depo-Provera:
- It is used to treat endometrial cancer.
- It is used to treat kidney cancer.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Depo-Provera?
For all patients taking Depo-Provera (medroxyprogesterone injection (400 mg/mL)):
- If you have an allergy to medroxyprogesterone or any other part of Depo-Provera (medroxyprogesterone injection (400 mg/mL)).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; liver disease; heart attack; stroke; or tumor where estrogen or progesterone make it grow.
- If you have had any of these health problems: Cancer of the uterus, ovary, cervix, or vagina; or vaginal bleeding where the cause is not known.
For all reasons other than cancer treatment:
- If you are pregnant or may be pregnant. Do not take Depo-Provera (medroxyprogesterone injection (400 mg/mL)) if you are pregnant.
This is not a list of all drugs or health problems that interact with Depo-Provera (medroxyprogesterone injection (400 mg/mL)).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Depo-Provera (medroxyprogesterone injection (400 mg/mL)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Depo-Provera?
- Tell all of your health care providers that you take Depo-Provera (medroxyprogesterone injection (400 mg/mL)). This includes your doctors, nurses, pharmacists, and dentists.
- Blood clots have happened with Depo-Provera (medroxyprogesterone injection (400 mg/mL)). Tell your doctor if you have ever had a blood clot. Talk with your doctor.
- Liver problems have happened. Call your doctor right away if you get signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Have a bone density test as you have been told by your doctor. Talk with your doctor.
- Take calcium and vitamin D as you were told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Depo-Provera (medroxyprogesterone injection (400 mg/mL)).
- This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- If you are 65 or older, use Depo-Provera (medroxyprogesterone injection (400 mg/mL)) with care. You could have more side effects.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- If you will be trying to get pregnant, it may take some time after your last dose of Depo-Provera (medroxyprogesterone injection (400 mg/mL)) to get pregnant. Talk with your doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Depo-Provera (medroxyprogesterone injection (400 mg/mL)) while you are pregnant.
How is this medicine (Depo-Provera) best taken?
Use Depo-Provera (medroxyprogesterone injection (400 mg/mL)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into a muscle.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
- Signs of Cushing's disease like weight gain in the upper back or belly, moon face, very bad headache, or slow healing.
- Chest pain or pressure.
- Shortness of breath.
- Coughing up blood.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Very bad headache.
- Very upset stomach or throwing up.
- Very bad belly pain.
- Very bad dizziness or passing out.
- Bulging eyes.
- Sudden change or loss of eyesight.
- Change in how contact lenses feel in the eyes.
- A lump in the breast, breast soreness, or nipple discharge.
- Breast pain.
- Vaginal itching or discharge.
- Vaginal bleeding that is not normal.
- Low mood (depression).
- Mood changes.
- Memory problems or loss.
- Swelling in hands or feet.
- Very bad irritation where the shot was given.
What are some other side effects of Depo-Provera?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Weight gain.
- Feeling sleepy.
- Feeling nervous and excitable.
- Upset stomach or throwing up.
- Change in sex interest.
- Pimples (acne).
- Feeling tired or weak.
- Enlarged breasts.
- Vaginal bleeding or spotting.
- Belly pain.
- Leg cramps.
- Not able to sleep.
- Period (menstrual) changes. Periods become less often or stop.
- Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Depo-Provera?
- Most of the time, Depo-Provera (medroxyprogesterone injection (400 mg/mL)) will be given in a hospital or doctor's office. If stored at home, follow how to store as you were told by the doctor.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Depo-Provera (medroxyprogesterone injection (400 mg/mL)), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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