Generic Name: Clomipramine (kloe MI pra meen)
Brand Name: Anafranil
Medically reviewed on May 2, 2018
- Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take clomipramine need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
- This medicine is not approved for use in all children. Talk with the doctor to be sure that clomipramine is right for your child.
Uses of Clomipramine:
- It is used to treat obsessive-compulsive problems.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Clomipramine?
- If you have an allergy to clomipramine or any other part of clomipramine.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had a recent heart attack.
- If you are taking any of these drugs: Linezolid or methylene blue.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking clomipramine within 14 days of those drugs can cause very bad high blood pressure.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with clomipramine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take clomipramine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Clomipramine?
- Tell all of your health care providers that you take clomipramine. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how clomipramine affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Do not stop taking clomipramine all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop clomipramine, you will want to slowly stop it as ordered by your doctor.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Some people may have a higher chance of eye problems with clomipramine. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.
- This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking clomipramine.
- Low platelet counts have rarely happened with clomipramine. This may lead to a higher chance of bleeding. Call your doctor right away if you have any unexplained bruising or bleeding.
- Low white blood cell counts have rarely happened with clomipramine. This may lead to a higher chance of getting an infection. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
- A very bad and sometimes deadly reaction has happened with clomipramine. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor.
- If you are 65 or older, use clomipramine with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using clomipramine while you are pregnant.
How is this medicine (Clomipramine) best taken?
Use clomipramine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with meals.
- It may take several weeks to see the full effects.
- To gain the most benefit, do not miss doses.
- Keep taking clomipramine as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Very bad dizziness or passing out.
- Feeling confused.
- Hallucinations (seeing or hearing things that are not there).
- Feeling very tired or weak.
- Chest pain or pressure or a fast heartbeat.
- A heartbeat that does not feel normal.
- Not able to pass urine or change in how much urine is passed.
- A burning, numbness, or tingling feeling that is not normal.
- Memory problems or loss.
- Not able to focus.
- Not able to get or keep an erection.
- Ejaculation problems.
- Change in sex interest.
- Swollen gland.
- Ringing in ears.
- A very bad and sometimes deadly health problem called serotonin syndrome may happen. The risk may be greater if you take clomipramine with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.
What are some other side effects of Clomipramine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Dry mouth.
- Hard stools (constipation).
- Loose stools (diarrhea).
- Belly pain.
- Upset stomach or throwing up.
- Feeling nervous and excitable.
- Feeling sleepy.
- Feeling tired or weak.
- Feeling more or less hungry.
- Weight gain.
- Weight loss.
- Muscle pain.
- Sweating a lot.
- Not able to sleep.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Clomipramine?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time clomipramine is refilled. If you have any questions about clomipramine, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about clomipramine
- Clomipramine Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 127 Reviews – Add your own review/rating
- Drug class: tricyclic antidepressants
Other brands: Anafranil
- Clomipramine Hydrochloride (AHFS Monograph)
- Clomipramine Capsules (FDA)
- ClomiPRAMINE (Wolters Kluwer)