Cinvanti (Intravenous)

Generic name: aprepitant [ ap-RE-pi-tant ]
Other brand names of aprepitant include: Aponvie, Cinvanti
Drug class: NK1 receptor antagonists

Medically reviewed by Drugs.com. Last updated on Dec 24, 2024.

Uses for Cinvanti

Aprepitant injection is used together with other medicines (eg, dexamethasone, granisetron, ondansetron) to prevent acute and delayed nausea and vomiting caused by cancer medicines (chemotherapy). It is also used to prevent nausea and vomiting that may occur after surgery. Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist that works by blocking the signals to the brain that cause nausea and vomiting.

This medicine is given only by or under the direct supervision of your doctor.

Before using Cinvanti

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of aprepitant injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aprepitant injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Eliglustat
Flibanserin
Levoketoconazole
Lomitapide
Pimozide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib
Adagrasib
Alfentanil
Alprazolam
Amiodarone
Amprenavir
Atazanavir
Avapritinib
Belzutifan
Benzhydrocodone
Boceprevir
Bosutinib
Brexpiprazole
Brigatinib
Buprenorphine
Carbamazepine
Ceritinib
Cilostazol
Cimetidine
Ciprofloxacin
Clarithromycin
Clofazimine
Clozapine
Cobicistat
Cobimetinib
Codeine
Colchicine
Conivaptan
Crizotinib
Cyclosporine
Dabrafenib
Daridorexant
Darunavir
Deflazacort
Desogestrel
Diazepam
Dienogest
Dihydrocodeine
Diltiazem
Docetaxel
Domperidone
Doxorubicin
Doxorubicin Hydrochloride Liposome
Dronedarone
Drospirenone
Duvelisib
Elacestrant
Elexacaftor
Encorafenib
Entrectinib
Enzalutamide
Eplerenone
Erythromycin
Estetrol
Estradiol
Ethinyl Estradiol
Ethynodiol
Etonogestrel
Etoposide
Fedratinib
Fentanyl
Fexinidazole
Finerenone
Fluconazole
Fluvoxamine
Fosamprenavir
Fosnetupitant
Fosphenytoin
Gepirone
Gestodene
Hydrocodone
Ibrutinib
Idelalisib
Ifosfamide
Imatinib
Indinavir
Infigratinib
Itraconazole
Ivabradine
Ivacaftor
Ivosidenib
Josamycin
Ketoconazole
Larotrectinib
Lefamulin
Lemborexant
Lenacapavir
Letermovir
Levonorgestrel
Lonafarnib
Lopinavir
Lorlatinib
Lumacaftor
Lumateperone
Lurasidone
Lurbinectedin
Mavacamten
Medroxyprogesterone
Meperidine
Mestranol
Methadone
Mibefradil
Mifepristone
Mitapivat
Mitotane
Mobocertinib
Naloxegol
Nefazodone
Nelfinavir
Netupitant
Nilotinib
Nomegestrol
Norelgestromin
Norethindrone
Norgestimate
Norgestrel
Olaparib
Olutasidenib
Omaveloxolone
Oxycodone
Paclitaxel
Pacritinib
Palovarotene
Pemigatinib
Pentazocine
Pexidartinib
Phenobarbital
Phenytoin
Piperaquine
Pirtobrutinib
Posaconazole
Pralsetinib
Primidone
Ranolazine
Ribociclib
Rifampin
Rifapentine
Rimegepant
Ritlecitinib
Ritonavir
Saquinavir
Schisandra sphenanthera
Segesterone
Selpercatinib
Selumetinib
Simeprevir
Sirolimus Protein-Bound
Sonidegib
Sparsentan
St John's Wort
Sufentanil
Tacrolimus
Tazemetostat
Telaprevir
Telithromycin
Tezacaftor
Tocilizumab
Tolvaptan
Tramadol
Treosulfan
Triazolam
Trofinetide
Troleandomycin
Tucatinib
Ubrogepant
Ulipristal
Venetoclax
Venlafaxine
Verapamil
Vinblastine
Vincristine
Vinorelbine
Voclosporin
Voriconazole
Voxelotor
Zanubrutinib
Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine
Dexamethasone
Methylprednisolone
Midazolam
Quetiapine
Sirolimus
Suvorexant
Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Proper use of Cinvanti

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.

For chemotherapy: This medicine may be injected for at least 2 minutes. It may also be given slowly, so the IV tube will have to stay in place for at least 30 minutes. It will be given on the first day of your chemotherapy session, along with other medicines (eg, dexamethasone, granisetron, ondansetron) about 30 minutes before the start of treatment.

For surgery: This medicine may be injected for at least 30 seconds before receiving anesthesia.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions while using Cinvanti

Check with your doctor if severe nausea and vomiting continue after leaving the medical facility.

Do not receive this medicine if you are also using pimozide (Orap®). Using these medicines together may cause serious unwanted effects.

Birth control that contains hormones (eg, pills, rings, implants, other devices) may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills during treatment with this medicine and for 1 month after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause a serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

This medicine may decrease the prothrombin time (time it takes for your blood to clot) when used together with warfarin (Coumadin®) in patients with blood clotting problems. Talk to your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of Cinvanti

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
sweating
unusual tiredness or weakness

Rare

Bloody, black, or tarry stools
burning feeling while urinating
chest pain or discomfort
chills
cough
defects in intelligence, short-term memory, learning ability, and attention
difficult or painful urination
fast, irregular, pounding, or racing heartbeat or pulse
fever
frequent urination
general feeling of discomfort or illness
heartburn
increased sensitivity of the skin to sunlight
increased volume of pale, dilute urine
indigestion
lightheadedness, dizziness, or fainting
lower back or side pain
pale skin
redness or other discoloration of the skin
severe and continuing nausea
severe stomach pain, cramping, burning
severe sunburn
slow heartbeat
sore throat
swelling
tender, swollen glands in the neck
trouble breathing
trouble walking
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
vomiting
vomiting of material that looks like coffee grounds

Incidence not known

Blistering, peeling, or loosening of the skin
chest tightness
diarrhea
difficulty swallowing
hives, itching, skin rash
joint or muscle pain
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
sore throat
sores, ulcers, or white spots in the mouth or on the lips
unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common