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What types of Hepatitis C does Mavyret treat?

Answers (1)

Official Answer by Drugs.com 10 Oct 2017

Mavyret (glecaprevir and pibrentasvir) from AbbVie is an 8 week oral treatment for all chronic hepatitis C virus (HCV) genotypes (1-6) in adult patients without cirrhosis (liver disease) who have not received previous treatments. Standard treatment length for HCV was previously 12 weeks or more. Mavyret inhibits NS3/4A protease and pibrentasvir inhibits NS5A.

Mavyret is FDA-approved for two patient populations: either chronic HCV genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A), or adult patients with HCV genotype 1 infection, previously treated with an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both. Studies demonstrated that 92 to 100 percent of patients had no virus detected in the blood 12 weeks after finishing treatment, suggesting a cure. The most commonly reported adverse reactions (> 10%) are headache and fatigue.

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