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Aspirin, Sodium Hydrogen Carbonate, Citric Acid
Read all of this leaflet carefully because it contains important information for you.
This medicine is available without prescription.
However, you still need to use Alka-Seltzer Original
carefully to get the best results from it.
• Keep this leaflet. You may need to read it again.
• Ask your pharmacist if you need more
information or advice.
• You must contact a doctor if your symptoms
worsen or do not improve after 3 days.
• If you have any unusual effects after using this
product, tell your doctor or pharmacist.

1. What is Alka-Seltzer Original and what is it
used for?
2. Before you take Alka-Seltzer Original
3. How to take Alka-Seltzer Original
4. Possible side effects
5. How to store Alka-Seltzer Original
6. Further information

Alka-Seltzer Original are effervescent tablets which
dissolve in water to give a sparkling solution. The
active substances are: aspirin (acetylsalicylic acid),
sodium hydrogen carbonate and citric acid.
Aspirin belongs to a group of medicines known as
non-steroidal anti-inflammatory drugs (NSAIDS).
It is used for the treatment of pain and reduction
of fever and also has anti-inflammatory properties.
Sodium hydrogen carbonate and citric acid help
create a sparkling solution.

Alka-Seltzer Original can be used for the:
• Treatment of mild to moderate pain including
headache, migraine, backache (including
lumbago), nerve pain (neuralgia and sciatica),
period pain, toothache and sore throat.
• Symptomatic relief of colds and influenza.
• Relief of rheumatic pain (arthritis), muscle
tenderness and stiffness (including fibrositis),
muscular aches and pains, the pain of joint
swelling and stiffness, strains and sprains.
• Effective reduction of high temperature.

DO NOT take Alka-Seltzer Original if you:
• Are allergic (hypersensitive) to aspirin, any other
salicylates (eg aloxiprin), or any of the other
ingredients of Alka Seltzer Original (see Section
6, Further Information).
• Have history of hypersensitivity reactions
(eg asthma, rhinitis, urticaria) induced by pain
relieving or anti-inflammatory medicines
(eg NSAIDS or salicylates).
• Have severe kidney or liver problems.
• Have severe heart problems.
• Have a disorder which causes excessive bleeding
such as haemophilia.
• Have, or have had, a stomach or duodenal ulcer.
• Are on a high dose of methotrexate (15mg per
week or more). If you are not sure, check with
your doctor. Also see ‘Using other medicines’.
• Are pregnant or breast-feeding, unless advised
by a doctor.
Speak to your doctor before taking Alka-Seltzer
Original if you:
• Are allergic (hypersensitive) to any other pain
relieving, anti-rheumatics or anti-inflammatory
medicines (eg NSAIDS). For more information
see section 4 ‘Possible Side Effects’.
• Suffer from tightness in the chest or asthma.
• Have low uric acid excretion, which is commonly
associated with gout.
• Have a history of gastrointestinal disorders
(regular stomach upsets).
• Have a deficiency in glucose-6-phosphate
dehydrogenase (G6PD), since you may
experience anaemia.
• Have kidney, liver, heart or blood circulation
• Are about to have surgery. Before the operation
tell the doctor or surgeon that you are taking
If you are not sure whether any of the above apply to
you, speak to a doctor or pharmacist before taking
Alka-Seltzer Original.
Important information about some of the
Each Alka-Seltzer Original tablet contains 477mg of
sodium. This should be taken into consideration by
people on a controlled sodium diet.

Use in children:
There is a possible association between aspirin and
Reye’s syndrome when given to children. Reye’s
syndrome is a very rare disease, which can be fatal.
For this reason aspirin should not be given to
children under 16 years, unless on the advice of a
Using other medicines:
Please tell your doctor or pharmacist if you are
taking or have recently taken any other medicines,
including medicines obtained without a prescription.
Aspirin can affect the way in which some medicines
work. These medicines include:
• Medication to prevent blood clotting (eg
warfarin, heparin, ticlopidine).
• Medication to treat heart problems or to lower
blood pressure (eg ACE inhibitors or digoxin).
• Medication to treat gout.
• Diuretics (to treat water retention).
• Medication to treat epilepsy (eg sodium
valproate, phenytoin).
• Medication to lower blood sugar if you are
• Methotrexate (to treat psoriasis, rheumatoid
arthritis, Crohn’s disease and some types of
• Any pain-relieving or anti-inflammatory
• Some antidepressants known as SSRIs
(eg fluoxetine, paroxetine).
• Medication to treat Addison’s disease
(eg corticosteroids except hydrocortisone).
Taking Alka-Seltzer Original with food and drink:
Avoid taking alcohol while taking Alka-Seltzer
Pregnancy and breast-feeding:
Do not take Alka-Seltzer Original if you are
pregnant, breast-feeding or trying for a baby unless
directed by your doctor. Aspirin can prolong labour
and affect blood clotting in the mother or baby.
Always ask your doctor or pharmacist for advice
before taking any medicine.

Follow the directions below closely. You should ask
your doctor or pharmacist if you are unsure how to
use this medicine.
Alka-Seltzer Original tablets must always be
dissolved in water before use.
Adults and children over 16:
Two tablets dissolved in half a glass (100ml) of water
may be taken every 4 hours as required. You should
not take more than 8 tablets in 24 hours.
Not recommended in children under 16.

Make sure you follow the dosage instructions and do
not take more than the stated dose.
Do not take Alka-Seltzer Original for more than
3 days in a row. If symptoms persist, speak to your
doctor or pharmacist.
If you take more Alka-Seltzer Original than you
If you think you have taken too many tablets you
should go to your nearest Accident and Emergency
Department or contact your doctor immediately.
Take this leaflet with you and any packaging to show
what you have taken.

Like all medicines Alka-Seltzer Original can cause
side effects although not everybody gets them.
If you experience any of the following side effects,
stop taking Alka-Seltzer Original and go to your
nearest Accident and Emergency Department or
doctor immediately:
• An allergic reaction. Signs of allergic reaction
may include: difficulty in breathing or
swallowing, swelling of the face, lips, throat or
tongue, skin rashes or itching, large or itchy
wheals on the skin, attacks of sneezing, runny
nose and itching eyes or water retention, heart
• Mild stomach pain and heartburn. These are the
most common side effects but can usually be
avoided if aspirin is taken with food.
• Stomach ulcer or perforation, stomach bleeding,
which may result in black or tarry stools.

• Dizziness or ringing in the ears.
• Increased bleeding/blood thinning (if you cut or
injure yourself), including bruises, nose bleeds,
bleeding gums.
• Internal bleeding which may result in anaemia
causing weakness, increased tiredness and pale
• An asthma attack if you are asthmatic and
sensitive to aspirin.
• Changes in normal liver activity in blood tests
(very rare).
• Runny nose, blocked nose.
• Kidney problems, kidney failure in patients who
already have kidney or heart problems.
If you have unusual stomach pains or react badly to
this medicine in any other way, stop taking AlkaSeltzer Original and tell your doctor or pharmacist

Keep out of the reach and sight of children.
Do not store above 25 °C. Store in a dry place. This
product should be stored in its original carton.
This product is packaged in pouches containing
2 tablets. If the pouch is opened and a tablet is not
used immediately, dispose of the tablet. If the pouch
is damaged or if a tablet is powdery or discoloured,
do not use the tablet.

Do not use Alka-Seltzer Original after the expiry
date which is stated on the carton and on the foil
pouch. The expiry date refers to the last day of that
Medicines should not be disposed of via wastewater
or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These
measures will help to protect the environment.

What Alka-Seltzer Original contains:
The active substances are aspirin (acetylsalicylic
acid) (324mg per tablet), sodium hydrogen
carbonate (1744mg per tablet) and citric acid (965mg
per tablet).
There are no other ingredients in Alka-Seltzer
See Section 2 ‘Important information about some of
the ingredients’ for sodium advice.
What Alka-Seltzer Original looks like and
contents of the pack:
Alka-Seltzer Original comes in cartons containing 2,
8, 10, 12, 20 or 30 white effervescent tablets packaged
in foil pouches. Not all pack sizes may be marketed.

Marketing Authorisation Holder:
Bayer plc
Consumer Care Division
Bayer House, Strawberry Hill
Newbury, Berkshire RG14 1JA
United Kingdom
Bayer Bitterfeld GmbH
OT Greppin
Salegaster Chaussee 1
06803 Bitterfeld-Wolfen
This leaflet was last revised in February 2012.
Alka-Seltzer® is a registered trademark.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.