Alka-Seltzer Original Interactions
There are 469 drugs known to interact with Alka-Seltzer Original (aspirin/citric acid/sodium bicarbonate), along with 11 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 69 are major, 331 are moderate, and 69 are minor.
- View all 469 medications that may interact with Alka-Seltzer Original
- View Alka-Seltzer Original alcohol/food interactions (2)
- View Alka-Seltzer Original disease interactions (11)
Most frequently checked interactions
View interaction reports for Alka-Seltzer Original (aspirin/citric acid/sodium bicarbonate) and the medicines listed below.
- acetaminophen
- albuterol
- amlodipine
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- cyclobenzaprine
- famotidine
- Flonase (fluticasone nasal)
- gabapentin
- hydrochlorothiazide
- ibuprofen
- levothyroxine
- lisinopril
- loratadine
- losartan
- magnesium oxide
- melatonin
- metformin
- Mucinex (guaifenesin)
- omeprazole
- ondansetron
- pantoprazole
- prednisone
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Alka-Seltzer Original alcohol/food interactions
There are 2 alcohol/food interactions with Alka-Seltzer Original (aspirin/citric acid/sodium bicarbonate).
Alka-Seltzer Original disease interactions
There are 11 disease interactions with Alka-Seltzer Original (aspirin/citric acid/sodium bicarbonate) which include:
- sodium/water balance
- coagulation
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- acid/base balance
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
Report options
More about Alka-Seltzer Original (aspirin/citric acid/sodium bicarbonate)
- Alka-Seltzer Original consumer information
- Compare alternatives
- Reviews (4)
- Side effects
- Drug class: salicylates
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.