Protonix Patient Tips
Medically reviewed by C. Fookes, BPharm. Last updated on Nov 13, 2018.
How it works
- Protonix is a brand (trade) name for pantoprazole. Pantoprazole reduces the production of stomach acid by irreversibly blocking the actions of an enzyme responsible for acid production, called H+/K+ ATPase (also known as the gastric proton pump). The proton pump is located in the parietal cells of the stomach wall. Both baseline gastric acid secretion and stimulated gastric acid secretion are affected; the degree that they are affected to depends upon the dose of pantoprazole.
- This allows damaged tissue in the esophagus, stomach, and duodenum to heal.
- Protonix belongs to the class of medicines known as proton pump inhibitors (PPIs).
- Effective at healing erosive esophagitis (a severe inflammation of the lining of the esophagus - the tube that carries food from the mouth to the stomach) and relieving symptoms of gastro-esophageal reflux disease (also known as heartburn).
- Useful in the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome.
- Usually, only up to 8 weeks of treatment is required; although it may be used for up to 12 months to maintain healing of erosive esophagitis.
- No dosage adjustment is needed in people with kidney or liver disease or in the elderly.
- Protonix is available as a generic under the name pantoprazole.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- A headache, fever, dizziness, nausea, diarrhea, cold-like symptoms (a sore throat, congested nose, sneezing), joint pain, and flatulence.
- May also interfere with some laboratory tests.
- May mask the symptoms of gastric malignancy. Further investigations should be carried out in people who have a suboptimal response to Nexium or an early symptomatic relapse once therapy has been discontinued. An endoscopy should be performed in seniors prior to administration of Protonix.
- PPIs (including Protonix) have been associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine. People on high-dose or long-term therapy are more at risk.
- Has also been associated with other conditions such as lupus erythematosus and magnesium deficiency.
- Prolonged treatment (greater than 24-36 months) may cause vitamin B12 deficiency. The risk is greater in women, people aged less than 30, and with higher dosages.
- Administration of PPIs (such as Protonix), has been associated with acute interstitial nephritis, a severe inflammation of the kidneys. May occur on medication initiation or at any point of therapy. Symptoms include fever, rash and generalized aches and pains. Discontinue Protonix and seek medical advice.
- Has been associated with a greater risk of Clostridium difficile-associated diarrhea. See your doctor if you develop diarrhea that does not improve.
- Will not provide instantaneous relief from heartburn symptoms. Antacids may be used to relieve these symptoms.
- Long-term use in animal studies has been associated with stomach cancer; it is not certain if Protonix has this effect in humans.
- Heartburn can cause similar symptoms to a heart attack. Seek urgent medical attention if you have chest pain, or pain that extends down your arm or up your neck, nausea, sweating and you feel unwell.
- Protonix may not be suitable for some people including those with severe liver disease, osteoporosis or low bone mineral density, or with low levels of magnesium in their blood. Not suitable for children under five.
- May interact with some other medications including antivirals used to treat HIV, methotrexate and sometimes warfarin. Protonix can also reduce the absorption of drugs that are dependant on a certain gastric pH for their absorption.
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- Protonix tablets can be taken with or without food. Do not crush, break or chew the tablet, swallow whole. Protonix oral granules should be taken 30 minutes before a meal; sprinkle directly onto one teaspoonful of applesauce or apple juice, stir and swallow straight away. Swallow delayed-release tablets whole; do not crush or chew.
- Usually taken once a day. May be taken with or without food.
- If using delayed-release granules, sprinkle intact granules on applesauce ONLY (do not use any other type of liquid including water). Swallow whole without chewing granules 30 minutes before a meal.
- May cause a false positive result on a drug screening test.
- Seek urgent medical advice if you have severe stomach pain, nausea, vomiting, diarrhea, seizures, blood in urine or urinating more frequently, or symptoms of low magnesium (confusion, dizziness, tremors, muscle spasms, abnormal heart rate).
- See your doctor if you develop any unexplained fever, rash (particularly one that gets worse after you have been in the sun), new or worsening joint pain, persistent diarrhea or generalized aches and pains.
Response and Effectiveness
- Peak effects happen within two and a half hours and start to decline after 12 hours although may last for over 24 hours.
Protonix (pantoprazole) Revised 06/2018. Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc. https://www.drugs.com/pro/protonix.html
More about Protonix (pantoprazole)
- Protonix Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 63 Reviews
- Generic Availability
- Drug class: proton pump inhibitors
- FDA Alerts (4)
- Protonix oral/injection
- Protonix (Pantoprazole Delayed-Release Granules)
- Protonix (Pantoprazole Delayed-Release Tablets)
- Protonix (Advanced Reading)
- Protonix Intravenous (Advanced Reading)
Related treatment guides
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Protonix only for the indication prescribed.
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