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Metoprolol Patient Tips

Medically reviewed on Jul 24, 2017 by C. Fookes, BPharm.

How it works

  • Metoprolol is a heart medication that belongs to a class of drugs known as beta-blockers. Metoprolol works by blocking the effects of epinephrine on beta-1 receptors within the heart tissue, causing the heart to pump more slowly and with less force. At high doses, metoprolol also blocks beta-2 receptors within the lungs and airways (which may affect breathing).
  • Metoprolol is available as two different salts: metoprolol tartrate and metoprolol succinate. These two salts are not interchangeable because they have different dosages, durations of action, and indications for use.

Upsides

Metoprolol tartrate

  • Lowers blood pressure and relieves symptoms of angina in people with heart disease or who have had a heart attack.
  • Immediate-release metoprolol tartrate has been shown to reduce the risk of death or another heart attack when given immediately following a heart attack.
  • May also be used to lower the risk of a heart attack in people with heart disease.
  • An injectable form is available which may be given by healthcare providers for people with unstable angina or arrhythmia.
  • May be used off-label for other conditions such as migraine prevention and to treat certain arrhythmias.
  • Classified as a "selective" beta-blocker meaning it is less likely to affect breathing and insulin response than other nonselective beta-blockers.
  • Generic forms are available.

Metoprolol succinate

  • Lowers blood pressure and relieves symptoms of angina in people with heart disease.
  • Slow-release forms may be beneficial in people with certain types of heart failure.
  • Available as a slow-release tablet which is usually dosed once a day.
  • Classified as a "selective" beta-blocker meaning it is less likely to affect breathing and insulin response than other nonselective beta-blockers.
  • Generic forms are available.

Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Heart rate slowing, depression, diarrhea, skin rash and shortness of breath. Side effects are similar for both metoprolol tartrate and metoprolol succinate because they both contain the same active drug, metoprolol.
  • Dry eyes; blurred vision; dizziness, particularly when rising from a sitting to standing position; fatigue; nightmares, slow heart beat, and sweating are common.
  • Less common side effects include facial and limb swelling, headache, visual disturbances, and tingling of the hands or feet.
  • Avoid abrupt discontinuation; stopping metoprolol (both tartrate and succinate) suddenly can exacerbate angina and may increase the risk of a heart attack. Reduce dosage gradually over a few weeks as instructed by your doctor.
  • May interfere slightly with laboratory cholesterol results.
  • 8% of the Caucasian population and approximately 2% of other populations have a reduced ability to metabolize metoprolol; the dosage of metoprolol may need reducing.
  • May not be suitable for some people including those with heart block greater than 1st degree, pheochromocytoma, poor circulation, sick sinus syndrome, a thyroid disorder, overt or decompensated heart failure, or under the age of 18.
  • Should be used with caution in people with pre-existing respiratory disease.
  • May decrease symptoms of hypoglycemia (such as a fast heart rate, palpitations, tremor, or feelings of anxiety) and increase the risk of insulin-induced hypoglycemia.
  • May also mask signs of hyperthyroidism (such as fast heart rate). May precipitate a thyroid storm if abruptly stopped.
  • May interact with some other medications including antidepressants, antipsychotics, ergot alkaloids, or some other blood pressure medications.

Metoprolol tartrate:

  • Only available as an immediate release tablet which means it must be taken several times per day.

Metoprolol succinate:

  • Should not be used to prevent heart attacks.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Metoprolol is a selective beta-blocker at dosages usually prescribed to lower blood pressure or relieve the symptoms of angina. Two different salts are available, metoprolol tartrate and metoprolol succinate. These are not interchangeable. Metoprolol should not be stopped abruptly.

Tips

  • Take tablets at the same time each day.
  • Report any shortness of breath or facial swelling immediately to your doctor.
  • Also talk to your doctor if you develop a very slow heartbeat or cold feeling in your hands or feet.
  • If you are diabetic, talk to your doctor about the possibility that metoprolol may reduce symptoms of hypoglycemia.
  • Talk to you doctor if you are having any side effects that are interfering with your quality of life. Do not stop taking metoprolol suddenly.
  • Do not substitute metoprolol tartrate with metoprolol succinate and vice versa.
  • Always check that your prescription is correct. There have been a number of dosing errors involving metoprolol tablets.
  • Your doctor will need to regularly monitor your blood pressure and possibly other markers. Keep your appointments.
  • Metoprolol may impair your thinking or reaction time and affect your ability to drive. Drinking alcohol may enhance these effects. Do not drive if you think your driving ability is being compromised by metoprolol.

Metoprolol tartrate

  • Food can affect absorption. Take tablets with or immediately following food.

Metoprolol succinate

  • Can be taken once daily.
  • Metoprolol succinate tablets can be taken with or without food.
  • Extended-release tablets may be scored or divided; however, do not crush or chew, swallow whole.

Response and Effectiveness

  • With oral metoprolol tartrate, significant effects on the heart rate are seen within an hour, and effects last for six to 12 hours depending on the dose. With injectable metoprolol tartrate, significant effects are seen within 20 minutes, and a single injection lasts for approximately 5 to 8 hours, depending on the dose. The duration of effect is dependent on the dose (meaning that larger dosages of metoprolol have a longer duration of action).
  • With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. With regular dosing; however, concentrations of metoprolol remain steady and do not fluctuate much. ER tablets are usually dosed once daily. The blood pressure lowering effects of ER tablets persist for about 24 hours.

References

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use metoprolol only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Drugs.com. Revision Date: 2017-07-25 02:42:09

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