Zeposia Side Effects
Generic name: ozanimod
Note: This document contains side effect information about ozanimod. Some dosage forms listed on this page may not apply to the brand name Zeposia.
Applies to ozanimod: oral capsules.
Side effects include:
MS trials (≥4%): Upper respiratory infection, liver enzyme elevations, orthostatic hypotension, urinary tract infection, back pain, hypertension.
UC trials (≥ 4%): Liver enzyme elevations, upper respiratory infection, headache.
For Healthcare Professionals
Applies to ozanimod: oral capsule.
Hypersensitivity
Frequency not reported: Hypersensitivity[Ref]
Immunologic
Uncommon (0.1% to 1%): Herpes zoster
Frequency not reported: Cryptococcal meningitis (CM)[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, arthralgia[Ref]
Ocular
Uncommon (0.1% to 1%): Macular edema[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Hepatic
Very common (10% or more): Aminotransferase elevations (e.g., alanine aminotransferase increased, gamma-glutamyl transferase increased, aspartate aminotransferase increased, hepatic enzyme increased, liver function test abnormal, transaminases increased) (10%)[Ref]
Oncologic
Frequency not reported: Malignancies (e.g., melanoma, basal cell carcinoma, breast cancer, seminoma, cutaneous malignancies)[Ref]
Respiratory
Very common (10% or more): Upper respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, respiratory tract infection, bronchitis, rhinitis, respiratory tract infection viral, viral upper respiratory tract infection, rhinorrhea, tracheitis, laryngitis) (26%)
Common (1% to 10%): Dose-dependent reductions in absolute FEV1 and FVC[Ref]
Other
Frequency not reported: Severe exacerbation of disease (e.g., disease rebound)[Ref]
Nervous system
Common (1% to 10%): Headache
Rare (0.01% to 0.1%): Progressive multifocal leukoencephalopathy (PML)[Ref]
Cardiovascular
Common (1% to 10%): Hypertension (e.g., hypertension, essential hypertension, orthostatic hypertension), peripheral edema
Uncommon (0.1% to 1%): Bradycardia
Frequency not reported: Atrioventricular conduction delays[Ref]
Dermatologic
Frequency not reported: Rash, urticaria[Ref]
Gastrointestinal
Common (1% to 10%): Upper abdominal pain, nausea[Ref]
General
Common (1% to 10%): Pyrexia[Ref]
Frequently asked questions
- What are the new drugs used for multiple sclerosis (MS)?
- Is ozanimod a biologic? How does it work?
- How long does it take ozanimod to work?
- Why does ozanimod slow down your heart rate?
More about Zeposia (ozanimod)
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- Drug class: selective immunosuppressants
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References
1. "Product Information. Zeposia (ozanimod)." Celgene Corporation (2020):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.