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Zeposia Side Effects

Generic name: ozanimod

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 19, 2022.

Note: This document contains side effect information about ozanimod. Some dosage forms listed on this page may not apply to the brand name Zeposia.

Applies to ozanimod: oral capsule.

Serious side effects of Zeposia

Along with its needed effects, ozanimod (the active ingredient contained in Zeposia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ozanimod:

More common

Less common


Incidence not known

For Healthcare Professionals

Applies to ozanimod: oral capsule.


Frequency not reported: Hypersensitivity[Ref]


Uncommon (0.1% to 1%): Herpes zoster

Frequency not reported: Cryptococcal meningitis (CM)[Ref]


Common (1% to 10%): Back pain, arthralgia[Ref]


Uncommon (0.1% to 1%): Macular edema[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Very common (10% or more): Aminotransferase elevations (e.g., alanine aminotransferase increased, gamma-glutamyl transferase increased, aspartate aminotransferase increased, hepatic enzyme increased, liver function test abnormal, transaminases increased) (10%)[Ref]


Frequency not reported: Malignancies (e.g., melanoma, basal cell carcinoma, breast cancer, seminoma, cutaneous malignancies)[Ref]


Very common (10% or more): Upper respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, respiratory tract infection, bronchitis, rhinitis, respiratory tract infection viral, viral upper respiratory tract infection, rhinorrhea, tracheitis, laryngitis) (26%)

Common (1% to 10%): Dose-dependent reductions in absolute FEV1 and FVC[Ref]


Frequency not reported: Severe exacerbation of disease (e.g., disease rebound)[Ref]

Nervous system

Common (1% to 10%): Headache

Rare (0.01% to 0.1%): Progressive multifocal leukoencephalopathy (PML)[Ref]


Common (1% to 10%): Hypertension (e.g., hypertension, essential hypertension, orthostatic hypertension), peripheral edema

Uncommon (0.1% to 1%): Bradycardia

Frequency not reported: Atrioventricular conduction delays[Ref]


Frequency not reported: Rash, urticaria[Ref]


Common (1% to 10%): Upper abdominal pain, nausea[Ref]


Common (1% to 10%): Pyrexia[Ref]

Frequently asked questions


1. Product Information. Zeposia (ozanimod). Celgene Corporation. 2020.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.