Zazole Side Effects

Generic name: terconazole topical

Medically reviewed by Drugs.com. Last updated on Oct 2, 2024.

Note: This document provides detailed information about Zazole Side Effects associated with terconazole topical. Some dosage forms listed on this page may not apply specifically to the brand name Zazole.

Applies to terconazole topical: vaginal cream, vaginal suppository.

Serious side effects of Zazole

Along with its needed effects, terconazole topical (the active ingredient contained in Zazole) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking terconazole topical:

More common side effects

• burning feeling in the vagina

Less common side effects

• chills
• fever
• itching or irritation in the vagina

Incidence not known

• blistering, peeling, or loosening of the skin
• chills
• cough
• diarrhea
• difficulty with swallowing
• dizziness
• fast heartbeat
• fever
• general feeling of discomfort or illness
• headache
• hives or welts
• hoarseness
• irritation
• itching
• joint or muscle pain
• joint pain, stiffness or swelling
• loss of appetite
• muscle aches and pains
• nausea
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• red skin lesions, often with a purple center
• red, irritated eyes
• redness of the skin
• runny nose
• shivering
• skin rash
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• sweating
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• trouble sleeping
• troubled breathing
• unusual tiredness or weakness
• vomiting

Other side effects of Zazole

Some side effects of terconazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• cramps
• headache
• heavy bleeding
• pain

Less common side effects

• abdominal or stomach pain
• body pain

Incidence not known

• difficulty with moving
• lack or loss of strength
• muscle aching or cramping
• muscle pain or stiffness
• swollen joints

For healthcare professionals

Applies to terconazole topical: vaginal cream, vaginal suppository.

Nervous system adverse events

• Very common (10% or more): Headache (up to 30.3%)
• Postmarketing reports: Dizziness^[Ref]

Headache was reported in 26%, 21%, and 30.3% of patients using the 0.4% vaginal cream, 0.8% vaginal cream, and vaginal suppositories, respectively. In clinical trials with the suppository, headache occurred in up to 20.7% of patients given placebo.^[Ref]

Local

Vaginal suppositories:

• Very common (10% or more): Burning (15.2%)
• Common (1% to 10%): Pruritus^[Ref]

The suppository formulation was discontinued most often due to burning and pruritus.^[Ref]

Frequency nor reported: Pain, rash

Genitourinary

Vaginal cream 0.4%:

• Frequency not reported: Vulvovaginal burning/itching/irritation

Vaginal cream 0.8%:

• Common (1% to 10%): Dysmenorrhea, genital burning and itching
• Frequency not reported: Vulvovaginal itching

Vaginal suppositories:

• Common (1% to 10%): Pain of the female genitalia^[Ref]

The cream formulations were discontinued most often due to vulvovaginal itching.^[Ref]

Other

• Frequency not reported: Influenza-like illness (consisting of fever, chills, nausea, dizziness)
• Postmarketing reports: Asthenia, influenza-like illness (consisting of multiple reactions including fever, chills, nausea, vomiting, myalgia, arthralgia, malaise), face edema
• Common (1% to 10%): Body pain, fever
• Uncommon (0.1% to 1%): Chills
• Uncommon (0.1% to 1%): Fever
• Common (1% to 10%): Body pain, fever, chills^[Ref]

Vaginal cream 0.4%

Vaginal cream 0.8%

Vaginal suppositories

Gastrointestinal

Vaginal cream 0.8%:

• Common (1% to 10%): Abdominal pain^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity, anaphylaxis^[Ref]

Dermatologic

• Frequency not reported: Photosensitivity reactions
• Postmarketing reports: Rash, toxic epidermal necrolysis, urticaria^[Ref]

Photosensitivity reactions were reported after repeated dermal application of 2% and 0.8% cream formulations under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with the suppositories or vaginal cream (0.4% and 0.8%).^[Ref]

Respiratory

• Frequency not reported: Dyspnea
• Postmarketing reports: Bronchospasm^[Ref]

At least 1 patient developed leukocytosis and dyspnea.^[Ref]

Hematologic

• Frequency not reported: Leukocytosis^[Ref]

At least 1 patient developed leukocytosis and dyspnea.^[Ref]

Further information

Zazole side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer