Yutrepia Side Effects

Generic name: treprostinil

Medically reviewed by Drugs.com. Last updated on Feb 8, 2025.

Note: This document provides detailed information about Yutrepia Side Effects associated with treprostinil. Some dosage forms listed on this page may not apply specifically to the brand name Yutrepia.

Applies to treprostinil: inhalation powder, inhalation solution.

Other dosage forms:

• oral tablet extended release
• injection solution

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

It is very important that your doctor check your blood pressure regularly while you are taking this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your recommended blood pressure, call your doctor right away.

This medicine may increase the risk of bleeding. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may make you dizzy, lightheaded, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Standing up slowly from a sitting or lying position can help.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Your doctor may adjust the doses of all the medicines you are taking or monitor you carefully for side effects.

Serious side effects of Yutrepia

Along with its needed effects, treprostinil (the active ingredient contained in Yutrepia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking treprostinil:

Get emergency help immediately if any of the following symptoms of overdose occur while taking treprostinil:

Symptoms of overdose

• blurred vision
• confusion
• diarrhea
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• headache
• nausea
• sweating
• unusual tiredness or weakness
• vomiting

Other side effects of Yutrepia

Some side effects of treprostinil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to treprostinil: inhalation powder, inhalation solution, injectable solution, oral tablet extended release.

General adverse events

Oral tablets: The most frequently reported side effects were headache, diarrhea, nausea, and flushing.

Oral inhalation: The most frequently reported side effects were cough, headache, diarrhea, nausea, dizziness, throat irritation, pharyngolaryngeal pain, and flushing.

Parenteral: The most frequently reported side effects were subcutaneous infusion site pain and reaction, headache, diarrhea, nausea, jaw pain, vasodilation, edema, and hypotension.^[Ref]

Local

• Very common (10% or more): Infusion site pain (up to 85%), infusion site reaction (up to 83%), Infusion site bleeding/bruising (33.5%)
• Frequency not reported: Induration, erythema, infusion site infection
• Postmarketing reports: Subcutaneous infusion site abscess^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 30%), nausea (up to 30%)
• Common (1% to 10%): Abdominal discomfort, rectal hemorrhage, melena, vomiting, abdominal pain, dyspepsia
• Frequency not reported: Gastrointestinal bleeding^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 63%)
• Common (1% to 10%): Syncope, paresthesia, dizziness^[Ref]

Cardiovascular

• Very common (10% or more): Flushing (15%), vasodilation (up to 11%)
• Common (1% to 10%): Hypotension, tachycardia, palpitation, hypertension, heart failure, bradycardia, hemorrhage
• Frequency not reported: Systemic blood pressure decreased, pallor, right ventricular heart failure, supraventricular tachycardia, hematoma
• Postmarketing reports: Thrombophlebitis^[Ref]

Dermatologic

• Very common (10% or more): Rash (up to 83.1%), pruritus (up to 13.6%)
• Common (1% to 10%): Contact dermatitis, sweating, ecchymosis, cellulitis
• Uncommon (0.1% to 1%): Skin ulcer
• Postmarketing reports: Angioedema, macular rash, popular rash^[Ref]

Musculoskeletal

• Very common (10% or more): Pain in extremity (14%), pain in jaw (up to 13.1%)
• Common (1% to 10%): Myalgia, back pain
• Uncommon (0.1% to 1%): Neck pain, arthralgia, leg cramp, muscle pain
• Postmarketing reports: Bone pain, muscle spasm^[Ref]

Respiratory

• Very common (10% or more): Cough (54%), throat irritation/pharyngolaryngeal pain (25%)
• Common (1% to 10%): Hypoxia, epistaxis, pharyngitis, dyspnea, sinusitis, pulmonary hypertension, rhinitis, hemoptysis
• Uncommon (0.1% to 1%): Bronchitis
• Frequency not reported: Wheezing, pneumonia^[Ref]

Other

• Very common (10% or more): Pain (11.9%)
• Common (1% to 10%): Edema, infection, flu syndrome, asthenia, overdose, chest pain, fever, peripheral edema
• Uncommon (0.1% to 1%): Viral infection, malaise
• Frequency not reported: Infection, fatigue, BUN decreased, LDH decreased, bilirubin decreased, swelling arm^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, anorexia, dehydration, gout^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Hematologic

• Common (1% to 10%): Anemia
• Frequency not reported: Bleeding, thrombocytopenia, WBC decreased, RBC decreased, hemoglobin decreased, hematocrit decreased, eosinophils increased, platelet count increased^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, anxiety, depression
• Uncommon (0.1% to 1%): Nervousness^[Ref]

Further information

Yutrepia side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer