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Vtama Side Effects

Generic name: tapinarof topical

Medically reviewed by Last updated on Mar 16, 2023.

Note: This document contains side effect information about tapinarof topical. Some dosage forms listed on this page may not apply to the brand name Vtama.

Applies to tapinarof topical: topical application cream.

Serious side effects of Vtama

Along with its needed effects, tapinarof topical (the active ingredient contained in Vtama) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tapinarof topical:

More common

Less common

For Healthcare Professionals

Applies to tapinarof topical: topical cream.


Very common (10% or more): Folliculitis (20%)

Common (1% to 10%): Contact dermatitis, pruritus, urticaria

Uncommon (0.1% to 1%): Drug eruption[Ref]

Adverse events which resulted in treatment discontinuation in greater than 1% of subjects were contact dermatitis (2.9%) and folliculitis (2.8%).[Ref]


Very common (10% or more): Nasopharyngitis (11%)

Common (1% to 10%): Influenza[Ref]


The most frequently reported adverse events included folliculitis and nasopharyngitis.[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


1. Product Information. Vtama (tapinarof topical). Dermavant Sciences, Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.