Verelan PM Side Effects

Generic name: verapamil

Medically reviewed by Drugs.com. Last updated on May 27, 2024.

Note: This document provides detailed information about Verelan PM Side Effects associated with verapamil. Some dosage forms listed on this page may not apply specifically to the brand name Verelan PM.

Applies to verapamil: intravenous solution.

Other dosage forms:

• oral capsule extended release, oral tablet, oral tablet extended release

Serious side effects of Verelan PM

Along with its needed effects, verapamil (the active ingredient contained in Verelan PM) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking verapamil:

Less common side effects

• blurred vision
• chest pain or discomfort
• confusion
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• fast, slow, pounding, or irregular heartbeat or pulse
• lightheadedness, dizziness, or fainting
• shortness of breath
• sweating
• unusual tiredness or weakness

Rare side effects

• cough
• difficulty breathing
• noisy breathing
• tightness in chest
• wheezing

Incidence not known

• convulsions
• loss of bladder control
• muscle spasm or jerking of all extremities
• sudden loss of consciousness

Other side effects of Verelan PM

Some side effects of verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• headache

Rare side effects

• hives or welts
• itching
• nausea
• redness of skin
• skin rash
• stomach soreness or discomfort

Incidence not known

• discouragement
• feeling of constant movement of self or surroundings
• feeling sad or empty
• increased sweating
• irritability
• lack of appetite
• loss of interest or pleasure
• sensation of spinning
• sleepiness
• tiredness
• trouble concentrating
• trouble sleeping
• uncontrolled eye movements

For healthcare professionals

Applies to verapamil: compounding powder, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release.

General adverse events

The most commonly reported side effects include constipation, dizziness, and headache.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 12.1%)
• Common (1% to 10%): Dizziness, lethargy
• Rare (0.01% to 0.1%): Seizures
• Frequency not reported: Rotary nystagmus, sleepiness, vertigo, lightheadedness, tingling, numbness, neuropathy
• Postmarketing reports: Syncope, cerebrovascular accident, equilibrium disorders, parkinsonism/extrapyramidal symptoms/syndrome, paresthesia, shakiness/tremor, paralysis/tetraparesis, somnolence^[Ref]

Seizures occurred rarely with IV administration.

Paralysis/tetraparesis was reported in a patient taking this drug and colchicine concurrently.^[Ref]

Cardiovascular

• Common (1% to 10%): Symptomatic hypotension/hypotension/abrupt blood pressure fall, sinus bradycardia/bradycardia (heart rate less than 50 beats/minute), severe tachycardia, ankle edema/edema, development/aggravation of congestive heart failure (CHF), atrioventricular (AV) block, peripheral edema
• Uncommon (0.1% to 1%): Second-/third-degree AV block, palpitations, orthostasis
• Postmarketing reports: Angina pectoris/chest pain, AV dissociation, ECG abnormal, claudication, hypertension, myocardial infarction, sinus arrest with asystole, decreased myocardial contractility, cardiogenic shock, bradyarrhythmia in atrial fibrillation, vasculitis, erythromelalgia^[Ref]

Cardiovascular side effects may occur with greater intensity at higher doses or in patients with a history of myocardial damage.

Approximately 15% of patients who had atrial flutter/fibrillation and received this drug and digoxin developed resting ventricular rates below 50 beats/min; in the same trial, asymptomatic hypotension occurred in approximately 5% of patients.

Asystole occurred after second/third degree AV block and was usually short in duration, with spontaneous cardiac action returning within seconds in the form of a sinus rhythm.^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, dyspepsia, nausea, diarrhea, flatulence
• Uncommon (0.1% to 1%): Abdominal discomfort/pain
• Frequency not reported: Non-obstructive paralytic ileus/ileus, bloating
• Postmarketing reports: Dry mouth, gastrointestinal stress, gingival hyperplasia, vomiting^[Ref]

Non-obstructive paralytic ileus was reversible when treatment was stopped.

Gingival hyperplasia occurred when this drug was given over a prolonged period of time, and was reversible once the drug was discontinued.^[Ref]

Respiratory

• Common (1% to 10%): Pulmonary edema, pharyngitis, sinusitis, rhinitis, dyspnea
• Rare (0.01% to 0.1%): Broncho/laryngeal spasm^[Ref]

Bronchospasm and laryngeal spasm occurred during hypersensitivity reactions.^[Ref]

Other

• Common (1% to 10%): Fatigue, tiredness/malaise, accidental injury, pain
• Frequency not reported: Infection, flu syndrome
• Postmarketing reports: Tinnitus, asthenia^[Ref]

Dermatologic

• Common (1% to 10%): Scalp irritation, rash
• Uncommon (0.1% to 1%): Itching, urticaria, flushing, exanthema
• Frequency not reported: Diaphoresis, photodermatitis
• Postmarketing reports: Ecchymosis, bruising, alopecia/hair loss, hyperkeratosis, macules, Stevens-Johnson syndrome, hyperhidrosis/sweating, erythema multiforme, Quincke's edema/angioneurotic edema^[Ref]

Itch and urticaria occurred in hypersensitivity reactions.^[Ref]

Psychiatric

• Common (1% to 10%): Sleep disturbance
• Uncommon (0.1% to 1%): Bad dreams, depression/emotional depression
• Postmarketing reports: Confusion, psychotic symptoms, insomnia, nervousness^[Ref]

Musculoskeletal

• Common (1% to 10%): Myalgia
• Frequency not reported: Muscle fatigue
• Postmarketing reports: Muscle cramps, arthralgia^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Elevated liver enzymes (transaminases, alkaline phosphatase)^[Ref]

Reversible elevations liver enzymes occurred during treatment, and are likely the result of a hypersensitivity reaction (e.g., allergic hepatitis).^[Ref]

Hypersensitivity

• Rare (0.01% to 0.1%): Hypersensitivity/allergic reactions
• Postmarketing reports: Allergy aggravated^[Ref]

Metabolic

• Frequency not reported: Lowered glucose tolerance
• Postmarketing reports: Hyperkalemia^[Ref]

Genitourinary

• Postmarketing reports: Galactorrhea, increased blood prolactin/hyperprolactinemia, increased urination, spotty menstruation, erectile dysfunction/impotence^[Ref]

Renal

• Postmarketing reports: Renal failure^[Ref]

Endocrine

• Postmarketing reports: Gynecomastia^[Ref]

Gynecomastia occurred in older male patients on prolonged treatment, and was reversible upon discontinuation of this drug.^[Ref]

Hematologic

• Postmarketing reports: Purpura^[Ref]

Ocular

• Postmarketing reports: Blurred vision^[Ref]

Further information

Verelan PM side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer