Tyvaso Side Effects
Generic name: treprostinil
Medically reviewed by Drugs.com. Last updated on Jan 31, 2024.
Note: This document contains side effect information about treprostinil. Some dosage forms listed on this page may not apply to the brand name Tyvaso.
Applies to treprostinil: injection solution. Other dosage forms:
Serious side effects of Tyvaso
Along with its needed effects, treprostinil (the active ingredient contained in Tyvaso) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking treprostinil:
More common
- Accumulation of blood at the site of injection
- dry, red, hot, or irritated skin
- feeling faint, dizzy, or lightheaded
- feeling of warmth or heat
- flushing or redness of the skin, especially on the face and neck
- headache
- redness, hardening of the skin, or rash at the site of injection
- swelling
Less common
- Blurred vision
- confusion
- dizziness, faintness, lightheadedness when getting up suddenly from a lying or sitting position
- sudden sweating
- unusual tiredness or weakness
Incidence not known
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- bone pain
- changes in skin color, pain, tenderness, or swelling of the foot or leg
- chest pain
- decreased urine output
- difficult or labored breathing
- dilated neck veins
- extreme tiredness or weakness
- irregular breathing
- irregular heartbeat
- itching, pain, redness, swelling, or tenderness on the skin
- paleness of the skin
- pinpoint red spots on the skin
- tightness in the chest
- troubled breathing
- unusual bleeding or bruising
- weight gain
Get emergency help immediately if any of the following symptoms of overdose occur while taking treprostinil:
Symptoms of overdose
- Loss of consciousness
- seizure
- unusual tiredness or weakness
Other side effects of Tyvaso
Some side effects of treprostinil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Diarrhea
- headache
- jaw pain
- nausea
Less common
- Lack or loss of strength
- loss of appetite
- stomach pain
- vomiting
- weight loss
Incidence not known
- Difficulty in moving
- dizziness
- joint pain
- muscle ache, cramp, pain, spasm, or stiffness
- pain in the arms or legs swollen joints
For Healthcare Professionals
Applies to treprostinil: inhalation powder, inhalation solution, injectable solution, oral tablet extended release.
General
Oral tablets: The most frequently reported side effects were headache, diarrhea, nausea, and flushing.
Oral inhalation: The most frequently reported side effects were cough, headache, diarrhea, nausea, dizziness, throat irritation, pharyngolaryngeal pain, and flushing.
Parenteral: The most frequently reported side effects were subcutaneous infusion site pain and reaction, headache, diarrhea, nausea, jaw pain, vasodilation, edema, and hypotension.[Ref]
Local
Very common (10% or more): Infusion site pain (up to 85%), infusion site reaction (up to 83%), Infusion site bleeding/bruising (33.5%)
Frequency not reported: Induration, erythema, infusion site infection
Postmarketing reports: Subcutaneous infusion site abscess[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (up to 30%), nausea (up to 30%)
Common (1% to 10%): Abdominal discomfort, rectal hemorrhage, melena, vomiting, abdominal pain, dyspepsia
Frequency not reported: Gastrointestinal bleeding[Ref]
Nervous system
Very common (10% or more): Headache (up to 63%)
Common (1% to 10%): Syncope, paresthesia, dizziness[Ref]
Cardiovascular
Very common (10% or more): Flushing (15%), vasodilation (up to 11%)
Common (1% to 10%): Hypotension, tachycardia, palpitation, hypertension, heart failure, bradycardia, hemorrhage
Frequency not reported: Systemic blood pressure decreased, pallor, right ventricular heart failure, supraventricular tachycardia, hematoma
Postmarketing reports: Thrombophlebitis[Ref]
Dermatologic
Very common (10% or more): Rash (up to 83.1%), pruritus (up to 13.6%)
Common (1% to 10%): Contact dermatitis, sweating, ecchymosis, cellulitis
Uncommon (0.1% to 1%): Skin ulcer
Postmarketing reports: Angioedema, macular rash, popular rash[Ref]
Musculoskeletal
Very common (10% or more): Pain in extremity (14%), pain in jaw (up to 13.1%)
Common (1% to 10%): Myalgia, back pain
Uncommon (0.1% to 1%): Neck pain, arthralgia, leg cramp, muscle pain
Postmarketing reports: Bone pain, muscle spasm[Ref]
Respiratory
Very common (10% or more): Cough (54%), throat irritation/pharyngolaryngeal pain (25%)
Common (1% to 10%): Hypoxia, epistaxis, pharyngitis, dyspnea, sinusitis, pulmonary hypertension, rhinitis, hemoptysis
Uncommon (0.1% to 1%): Bronchitis
Frequency not reported: Wheezing, pneumonia[Ref]
Other
Very common (10% or more): Pain (11.9%)
Common (1% to 10%): Edema, infection, flu syndrome, asthenia, overdose, chest pain, fever, peripheral edema
Uncommon (0.1% to 1%): Viral infection, malaise
Frequency not reported: Infection, fatigue, BUN decreased, LDH decreased, bilirubin decreased, swelling arm[Ref]
Metabolic
Common (1% to 10%): Hypokalemia, anorexia, dehydration, gout[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Hematologic
Common (1% to 10%): Anemia
Frequency not reported: Bleeding, thrombocytopenia, WBC decreased, RBC decreased, hemoglobin decreased, hematocrit decreased, eosinophils increased, platelet count increased[Ref]
Psychiatric
Common (1% to 10%): Insomnia, anxiety, depression
Uncommon (0.1% to 1%): Nervousness[Ref]
More about Tyvaso (treprostinil)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (17)
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: agents for pulmonary hypertension
- Breastfeeding
Patient resources
Other brands
Remodulin, Orenitram, Tyvaso DPI
Professional resources
Other brands
Remodulin, Orenitram, Tyvaso DPI
Related treatment guides
References
1. Product Information. Remodulin (treprostinil). United Therapeutics Corporation. 2002.
2. Cerner Multum, Inc. Australian Product Information.
3. Product Information. Tyvaso (treprostinil). United Therapeutics Corporation. 2009.
4. Product Information. Orenitram (treprostinil). United Therapeutics Corporation. 2017.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.